Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > SBU-Led Study Reveals Nanoparticles Found in Everyday Items Can Inhibit Fat Storage: Increase in gold nanoparticles can accelerate aging and wrinkling, slow wound healing, cause onset of diabetes

The team of researchers studying the effects of gold nanoparticles on the body, pictured from left to right (sitting) Marcia Simon, Tatsiana Mironava, (standing) Miriam Rafailovich and Michael Hadjiargyrou.
The team of researchers studying the effects of gold nanoparticles on the body, pictured from left to right (sitting) Marcia Simon, Tatsiana Mironava, (standing) Miriam Rafailovich and Michael Hadjiargyrou.

Abstract:
New research reveals that pure gold nanoparticles found in everyday items such as personal care products, as well as drug delivery, MRI contrast agents and solar cells can inhibit adipose (fat) storage and lead to accelerated aging and wrinkling, slowed wound healing and the onset of diabetes. The researchers, led by Tatsiana Mironava, a visiting assistant professor in the Department of Chemical and Molecular Engineering at Stony Brook University, detail their research, "Gold nanoparticles cellular toxicity and recovery: Adipose Derived Stromal cells," in the journal Nanotoxicology.

SBU-Led Study Reveals Nanoparticles Found in Everyday Items Can Inhibit Fat Storage: Increase in gold nanoparticles can accelerate aging and wrinkling, slow wound healing, cause onset of diabetes

Stony Brook, NY | Posted on April 19th, 2013

Together with co-author Dr. Marcia Simon, Professor of Oral Biology and Pathology at Stony Brook University, and Director of the University's Living Skin Bank, a world-class facility that has developed skin tissue for burn victims and various wound therapies, the researchers tested the impact of nanoparticles in vitro on multiple types of cells, including adipose (fat) tissue, to determine whether their basic functions were disrupted when exposed to very low doses of nanoparticles. Subcutaneous adipose tissue acts as insulation from heat and cold, functions as a reserve of nutrients, and is found around internal organs for padding, in yellow bone marrow and in breast tissue.

They discovered that the human adipose-derived stromal cells - a type of adult stem cells - were penetrated by the gold nanoparticles almost instantly and that the particles accumulated in the cells with no obvious pathway for elimination. The presence of the particles disrupted multiple cell functions, such as movement; replication (cell division); and collagen contraction; processes that are essential in wound healing.

According to the researchers, the most disturbing finding was that the particles interfered with genetic regulation, RNA expression and inhibited the ability to differentiate into mature adipocytes or fat cells. "Reductions caused by gold nanoparticles can result in systemic changes to the body," said Professor Mironava. "Since they have been considered inert and essentially harmless, it was assumed that pure gold nanoparticles would also be safe. Evidence to the contrary is beginning to emerge."

This study is also the first to demonstrate the impact of nanoparticles on adult stem cells, which are the cells our body uses for continual organ regeneration. It revealed that adipose derived stromal cells involved in regeneration of multiple organs, including skin, nerve, bone, and hair, ignored appropriate cues and failed to differentiate when exposed to nanoparticles. The presence of gold nanoparticles also reduced adiponectin, a protein involved in regulating glucose levels and fatty acid breakdown, which helps to regulate metabolism.

"We have learned that careful consideration and the choice of size, concentration and the duration of the clinical application of gold nanoparticles is warranted," said Professor Mironava. "The good news is that when the nanoparticles were removed, normal functions were eventually restored."

"Nanotechnology is continuing to be at the cutting edge of science research and has opened new doors in energy and materials science," said co-author, Miriam Rafailovich, PhD, Chief Scientist of the Advanced Energy Center and Distinguished Professor of Materials Science and Engineering at Stony Brook. "Progress comes with social responsibility and ensuring that new technologies are environmentally sustainable. These results are very relevant to achieving these goals."

The research, funded by the National Science Foundation Materials Research Science and Engineering Centers (MRSEC) and Polymer Programs, was a collaboration of Stony Brook University and New York State Stem Cell Science (NYSTEM). The paper was also co-authored by Michael Hadjiargyrou, Professor and Chairperson, Department of Life Sciences at New York Institute of Technology (NYIT) and former Professor in the Department of Biomedical Engineering at Stony Brook.

####

For more information, please click here

Contacts:
631.632.6310
Stony Brook University
310 Admin
Stony Brook, NY 11794-0701

Copyright © Stony Brook University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Download article - “Gold nanoparticles cellular toxicity and recovery: Adipose Derived Stromal cells,” in the journal Nanotoxicology:

Related News Press

News and information

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Exotic insulator may hold clue to key mystery of modern physics: Johns Hopkins-led research shows material living between classical and quantum worlds December 8th, 2016

Arrowhead Pharmaceuticals to Webcast Fiscal 2016 Year End Results December 7th, 2016

Journal Nanotechnology Progress International (JONPI), newest edition out December 7th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Exotic insulator may hold clue to key mystery of modern physics: Johns Hopkins-led research shows material living between classical and quantum worlds December 8th, 2016

Physicists decipher electronic properties of materials in work that may change transistors December 6th, 2016

Construction of practical quantum computers radically simplified: Scientists invent ground-breaking new method that puts quantum computers within reach December 5th, 2016

Nanomedicine

Arrowhead Pharmaceuticals to Webcast Fiscal 2016 Year End Results December 7th, 2016

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Journal Nanotechnology Progress International (JONPI) Volume 6, issue 2 coming out soon! December 5th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Discoveries

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Exotic insulator may hold clue to key mystery of modern physics: Johns Hopkins-led research shows material living between classical and quantum worlds December 8th, 2016

ANU invention to inspire new night-vision specs December 7th, 2016

Tokyo Institute of Technology research: 3D solutions to energy savings in silicon power transistors December 6th, 2016

Announcements

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Exotic insulator may hold clue to key mystery of modern physics: Johns Hopkins-led research shows material living between classical and quantum worlds December 8th, 2016

Arrowhead Pharmaceuticals to Webcast Fiscal 2016 Year End Results December 7th, 2016

Journal Nanotechnology Progress International (JONPI), newest edition out December 7th, 2016

Environment

Semiconductor-free microelectronics are now possible, thanks to metamaterials November 9th, 2016

First time physicists observed and quantified tiny nanoparticle crossing lipid membrane November 7th, 2016

Nanosensors on the alert for terrorist threats: Scientists interested in the prospects of gas sensors based on binary metal oxide nanocomposites November 5th, 2016

Marsden minds: Amazing projects revealed November 3rd, 2016

Safety-Nanoparticles/Risk management

First time physicists observed and quantified tiny nanoparticle crossing lipid membrane November 7th, 2016

SUN shares its latest achievements during the 3rd Annual Project Meeting November 1st, 2016

The Sustainable Nanotechnologies Project’s Final Events: Bringing Nano Environmental Health and Safety Assessment to the Wider Discussion on Risk Governance of Key Enabling Technologies November 1st, 2016

Exploding smartphones: What's the silent danger lurking in our rechargeable devices? New research identifies toxic emissions released by lithium-ion batteries October 21st, 2016

Research partnerships

Exotic insulator may hold clue to key mystery of modern physics: Johns Hopkins-led research shows material living between classical and quantum worlds December 8th, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Novel silicon etching technique crafts 3-D gradient refractive index micro-optics November 28th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project