Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > SBU-Led Study Reveals Nanoparticles Found in Everyday Items Can Inhibit Fat Storage: Increase in gold nanoparticles can accelerate aging and wrinkling, slow wound healing, cause onset of diabetes

The team of researchers studying the effects of gold nanoparticles on the body, pictured from left to right (sitting) Marcia Simon, Tatsiana Mironava, (standing) Miriam Rafailovich and Michael Hadjiargyrou.
The team of researchers studying the effects of gold nanoparticles on the body, pictured from left to right (sitting) Marcia Simon, Tatsiana Mironava, (standing) Miriam Rafailovich and Michael Hadjiargyrou.

Abstract:
New research reveals that pure gold nanoparticles found in everyday items such as personal care products, as well as drug delivery, MRI contrast agents and solar cells can inhibit adipose (fat) storage and lead to accelerated aging and wrinkling, slowed wound healing and the onset of diabetes. The researchers, led by Tatsiana Mironava, a visiting assistant professor in the Department of Chemical and Molecular Engineering at Stony Brook University, detail their research, "Gold nanoparticles cellular toxicity and recovery: Adipose Derived Stromal cells," in the journal Nanotoxicology.

SBU-Led Study Reveals Nanoparticles Found in Everyday Items Can Inhibit Fat Storage: Increase in gold nanoparticles can accelerate aging and wrinkling, slow wound healing, cause onset of diabetes

Stony Brook, NY | Posted on April 19th, 2013

Together with co-author Dr. Marcia Simon, Professor of Oral Biology and Pathology at Stony Brook University, and Director of the University's Living Skin Bank, a world-class facility that has developed skin tissue for burn victims and various wound therapies, the researchers tested the impact of nanoparticles in vitro on multiple types of cells, including adipose (fat) tissue, to determine whether their basic functions were disrupted when exposed to very low doses of nanoparticles. Subcutaneous adipose tissue acts as insulation from heat and cold, functions as a reserve of nutrients, and is found around internal organs for padding, in yellow bone marrow and in breast tissue.

They discovered that the human adipose-derived stromal cells - a type of adult stem cells - were penetrated by the gold nanoparticles almost instantly and that the particles accumulated in the cells with no obvious pathway for elimination. The presence of the particles disrupted multiple cell functions, such as movement; replication (cell division); and collagen contraction; processes that are essential in wound healing.

According to the researchers, the most disturbing finding was that the particles interfered with genetic regulation, RNA expression and inhibited the ability to differentiate into mature adipocytes or fat cells. "Reductions caused by gold nanoparticles can result in systemic changes to the body," said Professor Mironava. "Since they have been considered inert and essentially harmless, it was assumed that pure gold nanoparticles would also be safe. Evidence to the contrary is beginning to emerge."

This study is also the first to demonstrate the impact of nanoparticles on adult stem cells, which are the cells our body uses for continual organ regeneration. It revealed that adipose derived stromal cells involved in regeneration of multiple organs, including skin, nerve, bone, and hair, ignored appropriate cues and failed to differentiate when exposed to nanoparticles. The presence of gold nanoparticles also reduced adiponectin, a protein involved in regulating glucose levels and fatty acid breakdown, which helps to regulate metabolism.

"We have learned that careful consideration and the choice of size, concentration and the duration of the clinical application of gold nanoparticles is warranted," said Professor Mironava. "The good news is that when the nanoparticles were removed, normal functions were eventually restored."

"Nanotechnology is continuing to be at the cutting edge of science research and has opened new doors in energy and materials science," said co-author, Miriam Rafailovich, PhD, Chief Scientist of the Advanced Energy Center and Distinguished Professor of Materials Science and Engineering at Stony Brook. "Progress comes with social responsibility and ensuring that new technologies are environmentally sustainable. These results are very relevant to achieving these goals."

The research, funded by the National Science Foundation Materials Research Science and Engineering Centers (MRSEC) and Polymer Programs, was a collaboration of Stony Brook University and New York State Stem Cell Science (NYSTEM). The paper was also co-authored by Michael Hadjiargyrou, Professor and Chairperson, Department of Life Sciences at New York Institute of Technology (NYIT) and former Professor in the Department of Biomedical Engineering at Stony Brook.

####

For more information, please click here

Contacts:
631.632.6310
Stony Brook University
310 Admin
Stony Brook, NY 11794-0701

Copyright © Stony Brook University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Download article - “Gold nanoparticles cellular toxicity and recovery: Adipose Derived Stromal cells,” in the journal Nanotoxicology:

Related News Press

News and information

Black phosphorus is new 'wonder material' for improving optical communication March 3rd, 2015

Heightened Efficiency in Purification of Wastewater Using Nanomembranes March 3rd, 2015

Researchers turn unzipped nanotubes into possible alternative for platinum: Aerogel catalyst shows promise for fuel cells March 2nd, 2015

Important step towards quantum computing: Metals at atomic scale March 2nd, 2015

Govt.-Legislation/Regulation/Funding/Policy

Black phosphorus is new 'wonder material' for improving optical communication March 3rd, 2015

New nanodevice defeats drug resistance: Tiny particles embedded in gel can turn off drug-resistance genes, then release cancer drugs March 2nd, 2015

Forbidden quantum leaps possible with high-res spectroscopy March 2nd, 2015

Researchers turn unzipped nanotubes into possible alternative for platinum: Aerogel catalyst shows promise for fuel cells March 2nd, 2015

Nanomedicine

New nanodevice defeats drug resistance: Tiny particles embedded in gel can turn off drug-resistance genes, then release cancer drugs March 2nd, 2015

New Hopes for Treatment of Intestine Cancer by Edible Nanodrug March 2nd, 2015

Graphene Shows Promise In Eradication Of Stem Cancer Cells March 1st, 2015

Novel Method to Determine Optical Purity of Drug Components March 1st, 2015

Discoveries

Black phosphorus is new 'wonder material' for improving optical communication March 3rd, 2015

Heightened Efficiency in Purification of Wastewater Using Nanomembranes March 3rd, 2015

New nanodevice defeats drug resistance: Tiny particles embedded in gel can turn off drug-resistance genes, then release cancer drugs March 2nd, 2015

Breakthrough in OLED technology March 2nd, 2015

Announcements

Black phosphorus is new 'wonder material' for improving optical communication March 3rd, 2015

Heightened Efficiency in Purification of Wastewater Using Nanomembranes March 3rd, 2015

Researchers turn unzipped nanotubes into possible alternative for platinum: Aerogel catalyst shows promise for fuel cells March 2nd, 2015

Important step towards quantum computing: Metals at atomic scale March 2nd, 2015

Environment

Heightened Efficiency in Purification of Wastewater Using Nanomembranes March 3rd, 2015

Colon + septic tank = unique, at times stinky, study: Researchers use lab-scale human colon and septic tank to study impact of copper nanoparticles on the environment March 2nd, 2015

Simple, Cost-Efficient Method Used to Determine Toxicants Growing in Pistachio February 26th, 2015

Purification of Industrial Wastewater Using Visible-Light Sensitive Photocatalysts February 24th, 2015

Safety-Nanoparticles/Risk management

Colon + septic tank = unique, at times stinky, study: Researchers use lab-scale human colon and septic tank to study impact of copper nanoparticles on the environment March 2nd, 2015

Potential toxicity of cellulose nanocrystals examined in Industrial Biotechnology journal February 19th, 2015

A breakthrough in nanotoxicology by INRS researchers: Silver nanoparticles and inflammation February 18th, 2015

“Nanorama Laboratory“: Free Tool on Safe Handling of Nanomaterials Now Available in English! February 4th, 2015

Research partnerships

Breakthrough in OLED technology March 2nd, 2015

UC research partnership explores how to best harness solar power March 2nd, 2015

Researchers turn unzipped nanotubes into possible alternative for platinum: Aerogel catalyst shows promise for fuel cells March 2nd, 2015

Imec, Holst Centre and Renesas Present World’s Lowest Power 2.4GHz Radio Chip for Bluetooth Low Energy March 1st, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE