Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Indiana University surgeon's nanoparticle research takes inspiration from Greek mythology

This image from IU School of Medicine researcher Susan Clare shows macrophages carrying nanoparticles (with a fluorescent dye attached) at the site of metastatic breast tumor cells in the brain.

Credit: Susan Clare, M.D., Ph.D.
This image from IU School of Medicine researcher Susan Clare shows macrophages carrying nanoparticles (with a fluorescent dye attached) at the site of metastatic breast tumor cells in the brain.

Credit: Susan Clare, M.D., Ph.D.

Abstract:
An Indiana University School of Medicine breast cancer surgeon is pursuing research that will utilize glass, gold, nanotechnology and Greek mythology hoping to vanquish breast cancer that has metastasized to the brain.

Indiana University surgeon's nanoparticle research takes inspiration from Greek mythology

Indianapolis, IN | Posted on April 18th, 2013

Susan E. Clare, M.D., Ph.D., associate professor of surgery at the IU School of Medicine, is the initiating principal investigator for a $573,000 Department of Defense grant that will allow her to explore a new approach to delivering therapy to brain metastases from primary breast cancer.

As did the Greeks of old, Dr. Clare hopes to covertly deliver "warriors" to the enemy stronghold, in this case a metastatic brain tumor. Her research will explore using a cell from the body's immune system to deliver chemotherapy directly to the brain metastases. The drug or other therapeutic is attached to the nanospheres, which are carried within the immune cell, much as soldiers were carried within the Trojan Horse. The immune cells travel in the bloodstream and release the drug when it has reached the tumor site.

The two kinds of breast cancer that most commonly metastasize to the brain are HER2 positive and triple negative. There is no specifically targeted treatment available to treat triple negative metastatic tumors, but lapatinib is a standard treatment for HER2 positive cancer that has spread to other parts of the body.

"The problem for almost all drugs, and HER2-targeted drugs are no exception, is that the blood-brain barrier is a significant impediment to delivering therapies in concentrations that can be effective," Dr. Clare said. That biological issue caused Dr. Clare to explore other methods of delivering drugs to metastatic brain tumors.

Using nanoparticles called "nanoshells," developed by Naomi J. Halas, Ph.D., D.Sc., director of the Laboratory for Nanophotonics at Rice University, Dr. Clare hopes to target the brain tumors with lapatinib at a dose sufficient to shut down the signaling pathway needed for the cancer cells to proliferate.

In a July article in the journal Cancer Nanotechnology, Drs. Clare and Halas and colleagues showed that the immune cells carrying the nanoparticles were able to cross the blood-brain barrier and home in to brain metastases in an experimental mouse model.

First, a component of white blood cells called macrophages -- versatile cells that initiate an immune response after infiltrating abnormal (cancerous) cells -- are collected. The nanoparticles are ingested by the macrophages, which are then released into the bloodstream. Dr. Clare said the macrophages are attracted to the metastases by chemoattractants, which are chemicals produced by the tumor.

These nanoparticles are in Phase I clinical studies for the treatment of head and neck cancer, advanced prostate cancer and lung cancer through Nanospectra Biosciences, based in Houston, Texas. Because the blood-brain barrier was thought to be a significant impediment to delivery, their treatment effectiveness for brain metastases was not included in the initial testing. Dr. Clare's Department of Defense grant will allow research into three key areas.

The first goal is to show that the chemotherapy drugs can be tethered to the nanoparticles and released at will in the appropriate spot in the brain, Dr. Clare said. Releasing "at will" is critical in the process.

"The drug is released from the particle by shining a laser on the particle," she said. "The drug is transported between two pieces of DNA that are negatively charged. When exposed to the laser light, the electrons shift from the nanoparticle to the DNA, allowing it to release the drug."

The macrophages carry the nanoparticle directly to the cancer cells, so when the drug is released, it is exactly where it needs to be to diffuse to the tumor and interrupt the cellular activity of the metastatic cells.

Simple as that may sound, it is not.

The nanoparticle is a silica ball covered with gold, which has been proven to be nontoxic in extensive, long-term scientific studies. The thickness of the shell of gold determines where on the spectrum of light the laser light is absorbed. For maximum tissue penetration, the nanoparticles should absorb light in the near infrared. The nanoparticles developed by Dr. Halas do just that.

However, the bone of the skull presents an additional challenge to delivering sufficient laser power to the nanoparticle. Increasing the power of the laser is not the answer because it will burn the skin. There are many variables to the conundrum, but Dr. Clare has engaged Keith Stantz, Ph.D., adjunct assistant professor of radiology at the Indiana Institute of Biomedical Imaging Sciences, and Jacqueline A. Johnson, Ph.D., associate professor at the University of Tennessee Space Institute, both of whom are experts in nanosecond and femtosecond lasers. The team believes they have a solution to the power challenge and will test it in mouse models.

"That is a big piece of the puzzle," Dr. Clare said. "Gold is used as the shell for the particle because of its physical properties. Precise calculations for the thickness of the gold, the ideal depth of penetration and the power of the laser were challenges that had to be resolved before the effectiveness of the delivery system for the drug can be studied."

This research is funded by Department of Defense grant BC120825.

####

For more information, please click here

Contacts:
Mary Hardin

317-274-5456

Copyright © Indiana University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New solar power material converts 90 percent of captured light into heat: SunShot Project aims to make solar cost competitive October 29th, 2014

Tiny carbon nanotube pores make big impact October 29th, 2014

Microrockets fueled by water neutralize chemical and biological warfare agents October 29th, 2014

Nanosafety research – there’s room for improvement October 29th, 2014

Govt.-Legislation/Regulation/Funding/Policy

'Electronic skin' could improve early breast cancer detection October 29th, 2014

New solar power material converts 90 percent of captured light into heat: SunShot Project aims to make solar cost competitive October 29th, 2014

Tiny carbon nanotube pores make big impact October 29th, 2014

Microrockets fueled by water neutralize chemical and biological warfare agents October 29th, 2014

Discoveries

New solar power material converts 90 percent of captured light into heat: SunShot Project aims to make solar cost competitive October 29th, 2014

Tiny carbon nanotube pores make big impact October 29th, 2014

Microrockets fueled by water neutralize chemical and biological warfare agents October 29th, 2014

Nanoparticles Display Ability to Improve Efficiency of Filters October 28th, 2014

Announcements

New solar power material converts 90 percent of captured light into heat: SunShot Project aims to make solar cost competitive October 29th, 2014

Tiny carbon nanotube pores make big impact October 29th, 2014

Microrockets fueled by water neutralize chemical and biological warfare agents October 29th, 2014

Nanosafety research – there’s room for improvement October 29th, 2014

Military

Microrockets fueled by water neutralize chemical and biological warfare agents October 29th, 2014

Breakthrough in molecular electronics paves the way for DNA-based computer circuits in the future: DNA-based programmable circuits could be more sophisticated, cheaper and simpler to make October 27th, 2014

NanoTechnology for Defense (NT4D) October 22nd, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE