Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Traceable nanoparticles may be the next weapon in cancer treatment

Eva Malmström-Jonsson
Eva Malmström-Jonsson

Abstract:
Small particles loaded with medicine could be a future weapon for cancer treatment. A recently-published study shows how nanoparticles can be formed to efficiently carry cancer drugs to tumor cells. And because the particles can be seen in MRI images, they are traceable.

Traceable nanoparticles may be the next weapon in cancer treatment

Stockholm, Sweden | Posted on March 6th, 2013

Both therapeutic and diagnostic in function, the so-called "theranostic" particles were developed by a team including KTH Professor Eva Malmström-Jonsson, from the School of Chemical Science, as well as researchers at Sweden's Chalmer's University and the Karolinska Institute in Stockholm.

Malmström-Jonsson says that the particles, which the team developed for breast cancer treatment, are biodegradable and non-toxic. Their research was published in the science journal Particle & Particle Systems Characterization.

The study resulted in a method to make nanoparticles spontaneously build themselves up with tailored macromolecules. The formation requires a balance between the particle's hydrophilic (capable of dissolving in water) and hydrophobic (not dissolvable in water) parts. The hydrophobic portion makes it possible to fill the particle with the drug.

A relatively high concentration of the natural isotope 19F (fluorine) makes the particles clearly visible on high-resolution images taken by MRI (magnetic resonance imaging). By following the path of theranostic nanoparticles in the body, it is possible to obtain information about how the drug is taken up by the tumor and whether the treatment is working.

Scientists filled nanoparticles with the chemotherapy drug doxorubicin (known as chemo), which is used today to treat bladder, lung, ovarian and breast cancer, In experiments on cultured cells, they showed that the particles themselves are not harmful but can effectively kill cancer cells after being loaded with the drug.

The next step is to develop the system to target tumors that are difficult to treat with chemotherapy, such as brain tumors, pancreatic cancer, and drug-resistant breast cancer tumors.

"By targeting groups on the surface, or by changing the size or introducing ionic groups on our nanoparticles, one can increase the selective uptake in these tumors," says Andreas Nystrom, an associate professor of nanomedicine at the Swedish Medical Nanoscience Center and Department of Neuroscience, Karolinska Institute.

In the long term, research can result in tailored chemotherapy treatments that seek out tumor cells. This would enable the toxic drug to be delivered more specifically to the tumor, making the treatment more effective while reducing side effects.

"What we want to do is try to give nanoparticles a homing function on the surface so that the drug is as effective as possible and can be transported to the right place," Malmström-Jonsson says.

The study is funded in part by two grants from the Swedish Research Council to Andreas Nystrom and Eva Malmström-Jonsson. Malmström-Jonsson and Nystrom are also active in the company Polymer Factory Sweden AB.

####

About KTH The Royal Institute of Technology
Research at KTH includes not only technology but also natural and social sciences. Our varied research profile does support both general and special expertise, particularly in today´s top-priority subject areas, such as IT and biotechnology.

For more information, please click here

Contacts:
David Callahan

Copyright © AlphaGalileo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Sandia use confined nanoparticles to improve hydrogen storage materials performance: Big changes from a small package for hydrogen storage February 25th, 2017

New nano approach could cut dose of leading HIV treatment in half February 24th, 2017

Atom-scale oxidation mechanism of nanoparticles helps develop anti-corrosion materials February 24th, 2017

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Particle Works creates range of high performance quantum dots February 23rd, 2017

Imaging

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

JPK selects compact tensile stage from Deben for their NanoWizard® AFM platform to broaden capabilities for materials characterisation February 22nd, 2017

Govt.-Legislation/Regulation/Funding/Policy

Sandia use confined nanoparticles to improve hydrogen storage materials performance: Big changes from a small package for hydrogen storage February 25th, 2017

Atom-scale oxidation mechanism of nanoparticles helps develop anti-corrosion materials February 24th, 2017

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Molecular phenomenon discovered by advanced NMR facility: Cutting edge technology has shown a molecule self-assembling into different forms when passing between solution state to solid state, and back again - a curious phenomenon in science - says research by the University of Wa February 22nd, 2017

Nanomedicine

New nano approach could cut dose of leading HIV treatment in half February 24th, 2017

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Nominations Invited for $250,000 Kabiller Prize in Nanoscience: Major international prize recognizes a visionary nanotechnology researcher February 20th, 2017

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

Discoveries

Sandia use confined nanoparticles to improve hydrogen storage materials performance: Big changes from a small package for hydrogen storage February 25th, 2017

New nano approach could cut dose of leading HIV treatment in half February 24th, 2017

Atom-scale oxidation mechanism of nanoparticles helps develop anti-corrosion materials February 24th, 2017

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Announcements

Sandia use confined nanoparticles to improve hydrogen storage materials performance: Big changes from a small package for hydrogen storage February 25th, 2017

New nano approach could cut dose of leading HIV treatment in half February 24th, 2017

Atom-scale oxidation mechanism of nanoparticles helps develop anti-corrosion materials February 24th, 2017

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

Sandia use confined nanoparticles to improve hydrogen storage materials performance: Big changes from a small package for hydrogen storage February 25th, 2017

Oxford Instruments announces Dr Brad Ramshaw of Cornell University, as winner of the 2017 Lee Osheroff Richardson Science Prize February 20th, 2017

Nominations Invited for $250,000 Kabiller Prize in Nanoscience: Major international prize recognizes a visionary nanotechnology researcher February 20th, 2017

'Lossless' metamaterial could boost efficiency of lasers and other light-based devices February 20th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project