Home > Press > Gold Nanoparticles Help Determine Captopril Enzyme to Treat Different Diseases
Abstract:
Iranian researchers at Sharif University of Technology developed a new way to determine captopril enzyme quantitatively by using fluorescent resonance energy transfer (FRET) method.
Fluorescent resonance energy transfer method by using gold nanoparticles has recently been used to determine DNA, trombone, and so on. Therefore, Dr. Mohammad Reza Hormozinejad (assistant professor of Department of Chemistry) and his colleagues proposed a simple, highly sensitive, and selective method for the quantitative measurement of captopril in human blood plasma by using fluorescein isothiocyanate (FITC) modified with gold nanoparticles.
Hormozinejad is a member of the Scientific Board of Sharif University of Technology. He explained why gold nanoparticles have been used in the research.
"Gold and silver nanoparticles have high adsorption coefficient, which is caused by the surface plasmon resonance in their electrons. Therefore, these nanoparticles are known as plasmonic nanoparticles. They can attract light in various regions of the electromagnetic spectrum depending on their type, size, and formation. The researchers firstly produced colloidal gold nanoparticles, and then they modified them by using fluorescein isothiocyanate."
"Next, they added a solution of captopril with various concentrations to phosphate buffer of gold nanoparticles - fluorescein isothiocyanate, and they studied the fluorescent spectrum of its emitted fluorescein isothiocyanate. The amount of captopril in human blood plasma sample was measured in the end."
Results showed that in the beginning, the fluorescent emission of fluorescein isothiocyanate molecule was turned off by modifying the surface of gold nanoparticles with fluorescein isothiocyanate. However, when captopril was added to the mixture, the fluorescence of fluorescein isothiocyanate was turned on again due to the advantage of captopril in comparison with fluorescein isothiocyanate in carrying out interaction with the surface of gold nanoparticles.
Results of the research have been published in February 2013 in Journal of Luminescence, vol. 134. For more information about the detail of the research, visit the full article in the same journal on pages 874-879.
####
For more information, please click here
Copyright © Fars News Agency
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Related News Press |
News and information
Simulating magnetization in a Heisenberg quantum spin chain April 5th, 2024
NRL charters Navy’s quantum inertial navigation path to reduce drift April 5th, 2024
Discovery points path to flash-like memory for storing qubits: Rice find could hasten development of nonvolatile quantum memory April 5th, 2024
Nanomedicine
New micromaterial releases nanoparticles that selectively destroy cancer cells April 5th, 2024
Good as gold - improving infectious disease testing with gold nanoparticles April 5th, 2024
Researchers develop artificial building blocks of life March 8th, 2024
Discoveries
Chemical reactions can scramble quantum information as well as black holes April 5th, 2024
New micromaterial releases nanoparticles that selectively destroy cancer cells April 5th, 2024
Utilizing palladium for addressing contact issues of buried oxide thin film transistors April 5th, 2024
Announcements
NRL charters Navy’s quantum inertial navigation path to reduce drift April 5th, 2024
Discovery points path to flash-like memory for storing qubits: Rice find could hasten development of nonvolatile quantum memory April 5th, 2024
The latest news from around the world, FREE | ||
Premium Products | ||
Only the news you want to read!
Learn More |
||
Full-service, expert consulting
Learn More |
||