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Alumina scaffold with coatings made of the nanocomposite layer of hydroxyapatite/polycaprolactone fumarate and properties similar to bone tissues was synthesized by researchers at Tehran Science and Research Branch of Islamic Azad University.
The scaffold consists of integrated macro-pores with homogenous distribution and it has appropriate mechanical properties.
During the past decade, the use of porous bioceramics in the treatment of injured bones attracted the attention of many scientists. The pores in the bioceramic scaffold provide the new tissue with a 3-dimensional environment to grow. Therefore, cellular cultivation media can be easily available through the open pores.
The main problem with hydroxyapatite and other calcium phosphates is their weak mechanical properties including low strength and high fragility. However, alumina is appropriate for this application due to its desirable biocompatibility and mechanical properties.
Therefore, researchers produced alumina scaffold through the common technology of foam reproduction. Taking into account the obtained results, the mechanical strength of the produced scaffold is similar to that of human bone tissue. Silane pairing agent was used in order to create chemical bond between alumina scaffold and the coating. Coating process was carried out by floating the scaffold in solutions of nano hydroxyapatite with various concentrations.
In another section of the research, the scaffolds were analyzed at laboratorial conditions and inside animal bodies. Results showed that the samples could play an important role in the recovery of the injured bone tissues.
A part of the PhD thesis of Ms. Sediqeh Jooqehdoost has been published in January 2013 in Ceramics International, vol. 39, issue 1, pp. 209-218.
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