Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Oral delivery of colon cancer drug

Abstract:
Oral administration of anti-cancer agents is both more convenient and less painful than doing so intravenously. It can also afford controlled and sustained release, and reduce side-effects caused by the drug (or drugs). However, the environment which they have to pass through sets strict requirements for the materials used to transport them. Lingxue Kong and colleagues at Deakin University, Australia have now created a delivery vehicle for the cancer drug 5-fluorouracil (5-FU) that survives the harsh pH conditions en-route to the colorectal area.

Oral delivery of colon cancer drug

Germany | Posted on December 13th, 2012

Dispensing drugs orally to this area of the body is particularly difficult because the delivery system has to survive the three different acidity levels of the stomach, duodenum and small intestine (pH 1.2, 4.5 and 6.8, respectively) before releasing at pH 7.4 in the colon and rectum. Reporting in the Journal of Applied Polymer Science, the authors describe a water-in-oil-in-water multiple emulsion and solvent evaporation technique to first load 5-FU into poly(lactic-co-glycolic acid) nanoparticles. The drug loading, encapsulation efficiency and particle size were optimised by varying the fabrication parameters, including adjusting the pH value of the outer water phase to the isoelectric point of 5-FU. The loaded nanoparticles are subsequently coated with the anionic polymer Eudragit S100 based on methacrylic acid and methyl methacrylate. Importantly this is insoluble in aqueous solutions of pH 7 or less.

In vitro drug dissolution tests mimicking both the time spent passing through and acidity of each part of the human gastrointestinal tract show no 5-FU release at pH 1.2 and 4.5, with very limited release at pH 6.8. At pH 7.4 there is an initial burst release followed by an extended slow release of up to 120 hours. The system clearly shows promise for treatment of colorectal cancer because it overcomes the often seen problems of both early drug release from nanoparticles and poor functionality of microspheres.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Link to the original paper on Wiley Online Library:

Related News Press

News and information

Materials for the next generation of electronics and photovoltaics: MacArthur Fellow develops new uses for carbon nanotubes October 21st, 2014

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Could I squeeze by you? Ames Laboratory scientists model molecular movement within narrow channels of mesoporous nanoparticles October 21st, 2014

Nanomedicine

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

Design of micro and nanoparticles to improve treatments for Alzheimers and Parkinsons: At the Faculty of Pharmacy of the UPV/EHU-University of the Basque Country encapsulation techniques are being developed to deliver correctly and effectively certain drugs October 20th, 2014

Non-Toxic Nanocatalysts Open New Window for Significant Decrease in Reaction Process October 19th, 2014

European Commission opens the gate towards the implementation of Nanomedicine Translation Hub October 16th, 2014

Discoveries

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Could I squeeze by you? Ames Laboratory scientists model molecular movement within narrow channels of mesoporous nanoparticles October 21st, 2014

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

Announcements

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Could I squeeze by you? Ames Laboratory scientists model molecular movement within narrow channels of mesoporous nanoparticles October 21st, 2014

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE