Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Oral delivery of colon cancer drug

Abstract:
Oral administration of anti-cancer agents is both more convenient and less painful than doing so intravenously. It can also afford controlled and sustained release, and reduce side-effects caused by the drug (or drugs). However, the environment which they have to pass through sets strict requirements for the materials used to transport them. Lingxue Kong and colleagues at Deakin University, Australia have now created a delivery vehicle for the cancer drug 5-fluorouracil (5-FU) that survives the harsh pH conditions en-route to the colorectal area.

Oral delivery of colon cancer drug

Germany | Posted on December 13th, 2012

Dispensing drugs orally to this area of the body is particularly difficult because the delivery system has to survive the three different acidity levels of the stomach, duodenum and small intestine (pH 1.2, 4.5 and 6.8, respectively) before releasing at pH 7.4 in the colon and rectum. Reporting in the Journal of Applied Polymer Science, the authors describe a water-in-oil-in-water multiple emulsion and solvent evaporation technique to first load 5-FU into poly(lactic-co-glycolic acid) nanoparticles. The drug loading, encapsulation efficiency and particle size were optimised by varying the fabrication parameters, including adjusting the pH value of the outer water phase to the isoelectric point of 5-FU. The loaded nanoparticles are subsequently coated with the anionic polymer Eudragit S100 based on methacrylic acid and methyl methacrylate. Importantly this is insoluble in aqueous solutions of pH 7 or less.

In vitro drug dissolution tests mimicking both the time spent passing through and acidity of each part of the human gastrointestinal tract show no 5-FU release at pH 1.2 and 4.5, with very limited release at pH 6.8. At pH 7.4 there is an initial burst release followed by an extended slow release of up to 120 hours. The system clearly shows promise for treatment of colorectal cancer because it overcomes the often seen problems of both early drug release from nanoparticles and poor functionality of microspheres.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Link to the original paper on Wiley Online Library:

Related News Press

News and information

A nanoscale wireless communication system via plasmonic antennas: Greater control affords 'in-plane' transmission of waves at or near visible light August 27th, 2016

Forces of nature: Interview with microscopy innovators Gerd Binnig and Christoph Gerber August 26th, 2016

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Graphene under pressure August 26th, 2016

Nanomedicine

Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

50 years after the release of the film 'Fantastic Voyage,' science upstages fiction: Science upstages fiction with nanorobotic agents designed to travel in the human body to treat cancer August 25th, 2016

Tunneling nanotubes between neurons enable the spread of Parkinson's disease via lysosomes August 24th, 2016

Discoveries

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Graphene under pressure August 26th, 2016

Nanofur for oil spill cleanup: Materials researchers learn from aquatic ferns: Hairy plant leaves are highly oil-absorbing / publication in bioinspiration & biomimetics / video on absorption capacity August 25th, 2016

Unraveling the crystal structure of a -70 Celsius superconductor, a world first: Significant advancement in the realization of room-temperature superconductors August 25th, 2016

Announcements

A nanoscale wireless communication system via plasmonic antennas: Greater control affords 'in-plane' transmission of waves at or near visible light August 27th, 2016

Forces of nature: Interview with microscopy innovators Gerd Binnig and Christoph Gerber August 26th, 2016

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Graphene under pressure August 26th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic