Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Capturing living cells in micro pyramids

Chondrocyte captured inside a micro pyramid, interacting with its neighbours
Chondrocyte captured inside a micro pyramid, interacting with its neighbours

Abstract:
A field full of pyramids, but on a micro scale. Each of the pyramids hides a living cell. Thanks to 3D micro- and nano scale fabrication, promising new applications can be found. One of them is applying the micro pyramids for cell research: thanks to the open ‘walls' of the pyramids, the cells interact. Scientists of the research institutes MESA+ and MIRA of the University of Twente in The Netherlands present this new technology and first applications in Small journal of the beginning of December.

Capturing living cells in micro pyramids

Enschede, Netherlands | Posted on November 22nd, 2012

Most of the cell studies take place in 2D: this is not a natural situation, because cells organize themselves in another way than in the human body. If you give the cells room to move in three dimensions, the natural situation is approached in a better way while capturing them in an array. This is possible in the ‘open pyramids' fabricated in the NanoLab of the MESA+ Institute for Nanotechnology of the University of Twente.

Tiny corner remains filled

The cleanroom technology applied for this, has been discovered by coincidence and is now called ‘corner lithography'. If you join a number of flat silicon surface in a sharp corner, it is possible to deposit another material on them. After having removed the material, however, a small amount of material remains in the corner. This tiny tip can be used for an Atomic Force Microscope, or, in this case, for forming a micro pyramid.

Catching cells

In cooperation with UT's MIRA Institute for Biomedical Technology and Technical Medicine, the nanoscientists have explored the possibilities of applying the pyramids as ‘cages' for cells. First experiments with polystyrene balls worked out well. The next experiments involved capturing chondrocytes, cells forming cartilage. Moved by capillary fluid flow, these cells automatically ‘fall' into the pyramid through a hole at the bottom. Soon after they settle in their 3D cage, cells begin to interact with cells in adjacent pyramids. Changes in the phenotype of the cell can now be studied in a better way than in the usual 2D situation. It is therefore a promising tool to be used in for example tissue regeneration research.

The Dutch scientists expect to develop extensions to this technology: the edges of the pyramid can be made hollow and function as fluid channels. Between the pyramids, it is also possible to create nanofluidic channels, for example used to feed the cells.


Full bibliographic informationThe article ‘3D Nanofabrication of Fluidic Components by Corner Lithography' by Erwin Berenschot, Narges Barouni, Bart Schurink, Joost van Honschoten†, Remco Sanders, Roman Truckenmuller, Henri Jansen, Miko Elwenspoek, Aart van Apeldoorn en Niels Tas will be published as an ‘inside cover' article in Wiley's Small journal. It is already available online.

####

For more information, please click here

Contacts:
Wiebe van der Veen
+31612185692

Copyright © AlphaGalileo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Rutgers, NIST physicists report technology with potential for sub-micron optical switches March 31st, 2015

Prototype 'nanoneedles' generate new blood vessels in mice: Scientists have developed tiny 'nanoneedles' that have successfully prompted parts of the body to generate new blood vessels, in a trial in mice March 31st, 2015

Super sensitive measurement of magnetic fields March 31st, 2015

Nanomedicine pioneer Mauro Ferrari at ETH Zurich March 31st, 2015

Microfluidics/Nanofluidics

Square ice filling for a graphene sandwich March 26th, 2015

Dolomite’s microfluidics technology ideal for B cell encapsulation March 24th, 2015

Going with the flow January 16th, 2015

How bacteria control their size: By monitoring thousands of individual bacteria scientists discovered how they maintain their size from generation to generation January 6th, 2015

Nanomedicine

Nanomedicine shines light on combined force of nanomedicine and regenerative medicine March 31st, 2015

Prototype 'nanoneedles' generate new blood vessels in mice: Scientists have developed tiny 'nanoneedles' that have successfully prompted parts of the body to generate new blood vessels, in a trial in mice March 31st, 2015

Nanomedicine pioneer Mauro Ferrari at ETH Zurich March 31st, 2015

Wrapping carbon nanotubes in polymers enhances their performance: Scientists at Japan's Kyushu University say polymer-wrapped carbon nanotubes hold much promise in biotechnology and energy applications March 30th, 2015

Discoveries

Rutgers, NIST physicists report technology with potential for sub-micron optical switches March 31st, 2015

Prototype 'nanoneedles' generate new blood vessels in mice: Scientists have developed tiny 'nanoneedles' that have successfully prompted parts of the body to generate new blood vessels, in a trial in mice March 31st, 2015

Super sensitive measurement of magnetic fields March 31st, 2015

From tobacco to cyberwood March 31st, 2015

Announcements

Rutgers, NIST physicists report technology with potential for sub-micron optical switches March 31st, 2015

Prototype 'nanoneedles' generate new blood vessels in mice: Scientists have developed tiny 'nanoneedles' that have successfully prompted parts of the body to generate new blood vessels, in a trial in mice March 31st, 2015

Super sensitive measurement of magnetic fields March 31st, 2015

Nanomedicine pioneer Mauro Ferrari at ETH Zurich March 31st, 2015

Nanobiotechnology

From tobacco to cyberwood March 31st, 2015

Wrapping carbon nanotubes in polymers enhances their performance: Scientists at Japan's Kyushu University say polymer-wrapped carbon nanotubes hold much promise in biotechnology and energy applications March 30th, 2015

'Atomic chicken-wire' is key to faster DNA sequencing March 30th, 2015

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Printing/Lithography/Inkjet/Inks

Haydale Announce Dedicated Graphene Inks Manufacturing Capability March 25th, 2015

NC State researchers create 'nanofiber gusher': Report method of fabricating larger amounts of nanofibers in liquid March 19th, 2015

'Additive manufacturing' could greatly improve diabetes management March 17th, 2015

Advantest to Exhibit at SEMICON China in Shanghai, China, March 17-19: Showcasing Broad Portfolio of Semiconductor Products, Technologies and Solutions March 10th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE