Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > NIST study suggests carbon nanotubes may protect DNA from oxidation

Scanning electron microscope image of a typical sample of the NIST single-wall carbon nanotube soot standard reference material. Recent NIST research suggests that, at least in the laboratory, carbon nanotubes may help protect DNA molecules from damage by oxidation. The image shows an area just over a micrometer wide. (Color added for clarity.)

Credit: Credit: Vladar, NIST
Scanning electron microscope image of a typical sample of the NIST single-wall carbon nanotube soot standard reference material. Recent NIST research suggests that, at least in the laboratory, carbon nanotubes may help protect DNA molecules from damage by oxidation. The image shows an area just over a micrometer wide. (Color added for clarity.)

Credit: Credit: Vladar, NIST

Abstract:
Researchers at the National Institute of Standards and Technology (NIST) have provided evidence in the laboratory that single-wall carbon nanotubes (SWCNTs) may help protect DNA molecules from damage by oxidation. In nature, oxidation is a common chemical process in which a reactive chemical removes electrons from DNA and may increase the chance for mutations in cells. More studies are needed to see if the in vitro protective effect of nanotubes reported in the laboratory also occurs in vivo, that is, within a living organism.

NIST study suggests carbon nanotubes may protect DNA from oxidation

Gaithersburg, MD | Posted on November 15th, 2012

"Our findings don't tell us whether carbon nanotubes are good or bad for people and the environment," says Elijah Petersen, one of the authors of the study. "However, the results do help us better understand the mechanisms by which nanotubes might interact with biomolecules."

Single-wall carbon nanotubes—tiny hollow rods that are one-atom-thick sheets of graphene rolled into cylinders 10,000 times smaller in diameter than a human hair—are prized for their extraordinary optical, mechanical, thermal and electronic properties. They are being used to produce lightweight and extremely strong materials, enhance the capabilities of devices such as sensors, and provide a novel means of delivering drugs with great specificity. However, as carbon nanotubes become increasingly incorporated into consumer and medical products, the public concern about their potential environmental, health and safety (EHS) risks has grown. Scientifically determining the level of risk associated with the carbon nanotubes has been challenging, with different studies showing conflicting results on cellular toxicity. One of the components lacking in these studies is an understanding of what physically happens at the molecular level.

In a recent paper,* NIST researchers investigated the impact of ultrasonication on a solution of DNA fragments known as oligomers in the presence and absence of carbon nanotubes. Ultrasonication is a standard laboratory technique that uses high-frequency sound waves to mix solutions, break open cells or process slurries. The process can break water molecules into highly reactive agents such as hydroxyl radicals and hydrogen peroxide that are similar to the oxidative chemicals that commonly threaten mammalian cell DNA, although the experimental levels from sonication are much greater than those found naturally within cells. "In our experiment, we were looking to see if the nanotubes enhanced or deterred oxidative damage to DNA," Petersen says.

Contrary to the expectation that carbon nanotubes will damage biomolecules they contact, the researchers found that overall levels of accumulated DNA damage were significantly reduced in the solutions with nanotubes present. "This suggests that the nanotubes may provide a protective effect against oxidative damage to DNA," Petersen says.

A possible explanation for the surprising result, Petersen says, is that the carbon nanotubes may act as scavengers, binding up the oxidative species in solution and preventing them from interacting with DNA. "We also saw a decrease in DNA damage when we did ultrasonication in the presence of dimethyl sulfoxide (DMSO), a chemical compound known to be a hydroxyl radical scavenger," Petersen says.

Petersen says that a third experiment where ultrasonication was performed in the presence of DMSO and SWCNTs at the same time produced an additive effect, reducing the DNA damage levels more significantly than either treatment alone.

This research is part of NIST's work to help characterize the potential EHS risks of nanomaterials, and develop methods for identifying and measuring them.

* E.J. Petersen, X. Tu, M. Dizdaroglu, M. Zheng and B.C. Nelson. Protective roles of single-wall carbon nanotubes in ultrasonication-induced DNA base damage. Small (2012), DOI: 10/1002/smll.201201217.

####

For more information, please click here

Contacts:
Michael E. Newman

301-975-3025

Copyright © National Institute of Standards and Technology (NIST)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Ultra-short pulse lasers & Positioning August 21st, 2014

Malvern’s Dr Alan Rawle talks TLAs in plenary lecture at Particulate Systems Analysis conference August 21st, 2014

Water window imaging opportunity: A new theoretical study elucidates mechanisms that could help in producing coherent radiations, ultimately promoting high-contrast imaging of biological samples August 21st, 2014

Nanotechnology Helps Production of Super Adsorbent Polymers August 21st, 2014

Laboratories

Promising Ferroelectric Materials Suffer From Unexpected Electric Polarizations: Brookhaven Lab scientists find surprising locked charge polarizations that impede performance in next-gen materials that could otherwise revolutionize data-driven devices August 18th, 2014

Research of Empa scientists on the cover of "Nature": Synthesis of structurally pure carbon nanotubes using molecular seeds August 7th, 2014

FEI Reports New Advances in Neuroscience in Collaboration with NIH: Using cryo-electron microscopy, researchers determine the structural mechanism of glutamate receptors – an important insight to the brain’s memory formation and learning August 4th, 2014

New Method Provides Nanoscale Details of Electrochemical Reactions in Electric Vehicle Battery Materials August 4th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Success in Intracellular Imaging of Cesium Distribution in Plants Used for Cesium Absorption August 19th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

Promising Ferroelectric Materials Suffer From Unexpected Electric Polarizations: Brookhaven Lab scientists find surprising locked charge polarizations that impede performance in next-gen materials that could otherwise revolutionize data-driven devices August 18th, 2014

Novel chip-based platform could simplify measurements of single molecules: A nanopore-gated optofluidic chip combines electrical and optical measurements of single molecules onto a single platform August 14th, 2014

Nanotubes/Buckyballs

Iranian Scientists Stabilize Protein on Highly Stable Electrode Surface August 14th, 2014

SouthWest NanoTechnologies Appoints Matteson-Ridolfi for U.S. Distribution of its SMW™ Specialty Multiwall Carbon Nanotubes August 13th, 2014

Immune cells get cancer-fighting boost from nanomaterials August 13th, 2014

SouthWest NanoTechnologies Inc. Announces $2.7 Million in New Financing to Fund Growth, Plant Expansion and Technical Personnel August 11th, 2014

Nanomedicine

Ultra-short pulse lasers & Positioning August 21st, 2014

Nanotechnology Helps Production of Super Adsorbent Polymers August 21st, 2014

Newly-Developed Nanobiosensor Quickly Diagnoses Cancer August 20th, 2014

Graphene rubber bands could stretch limits of current healthcare, new research finds August 19th, 2014

Discoveries

Water window imaging opportunity: A new theoretical study elucidates mechanisms that could help in producing coherent radiations, ultimately promoting high-contrast imaging of biological samples August 21st, 2014

Nanotechnology Helps Production of Super Adsorbent Polymers August 21st, 2014

Newly-Developed Nanobiosensor Quickly Diagnoses Cancer August 20th, 2014

Ultrasonic Waves Applied in Production of Graphene Nanosheets August 20th, 2014

Announcements

Ultra-short pulse lasers & Positioning August 21st, 2014

Malvern’s Dr Alan Rawle talks TLAs in plenary lecture at Particulate Systems Analysis conference August 21st, 2014

Water window imaging opportunity: A new theoretical study elucidates mechanisms that could help in producing coherent radiations, ultimately promoting high-contrast imaging of biological samples August 21st, 2014

Nanotechnology Helps Production of Super Adsorbent Polymers August 21st, 2014

Nanobiotechnology

The channel that relaxes DNA: Relaxing DNA strands by using nano-channels: Instructions for use August 20th, 2014

Сalculations with Nanoscale Smart Particles August 19th, 2014

Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran August 17th, 2014

Scientists fold RNA origami from a single strand: RNA origami is a new method for organizing molecules on the nanoscale. Using just a single strand of RNA, this technique can produce many complicated shapes. August 14th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE