Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Self-Assembling Nanofilaments Enhance Drug Delivery

Abstract:
While most nanoparticles under development as drug delivery vehicles are spheres, a growing body of research suggests that cylindrical nanoparticles would perform even better at the twin goal of surviving in the blood stream long enough to reach their intended target and penetrating the cell wall to deliver their therapeutic payload inside of tumor cells where it is most needed. A team of investigators at the Northwestern University Center of Cancer Nanotechnology Excellence (Northwestern CCNE) has invented a cylindrical nanofilament structure that significantly reduces tumor growth in an animal model of breast cancer.

Self-Assembling Nanofilaments Enhance Drug Delivery

Bethesda, MD | Posted on October 21st, 2012

A team led by Vincent Cryns, who recently moved from Northwestern to the University of Wisconsin School of Medicine and Public Health, and Samuel Stupp, developed the self-assembling nanofibers. The investigators report their findings in the journal ACS Nano.

To create their tumor-inhibiting cylinders, the investigators turned to a family of molecules known as peptide amphiphiles. When put into water, these molecules, which can be made using automated peptide synthesizers, which spontaneously self-assemble into long, thin filaments. Depending on the choice of starting materials, these filaments can display large number of biologically active peptides on their surfaces that enable the fibers to serve as both drugs and drug deliver agents simultaneously without the need to further encapsulate anticancer agents within the nanostructure.

In earlier work, the Northwestern CCNE team had shown that one such nanofiber was more toxic to cancer cells than non-malignant cells, but this nanofiber was degraded rapidly in the blood stream. To improve the pharmacokinetic properties of their nanofiber, the investigators created a second peptide amphiphile, this one linked to poly(ethylene glycol) (PEG), a polymer widely used to increase the survival of nanoparticles in the blood stream. When the researchers mixed the peptide amphiphile with the PEGylated amphiphile, the two molecules together self-assembled into nanofilaments. By adding the PEGylated peptide amphiphile to the mix the investigators increased by eight-fold the amount of intact nanofiber that survived degradation by the enzyme trypsin compared to the original nanofiber.

To see if this nanofiber showed promise in a live animal studies, the investigators administered it to mice with human breast tumors. After dosing the animals twice weekly for three weeks, the researchers observed that the tumors in the treated animals grew much slower than in control animals. They also noted that the animals showed no signs of drug-related toxicities.

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Coassembled cytotoxic and pegylated peptide amphiphiles form filamentous nanostructures with potent antitumor activity in models of breast cancer.”

Related News Press

News and information

Leti IEDM 2016 Paper Clarifies Correlation between Endurance, Window Margin and Retention in RRAM for First Time: Paper Presented at IEDM 2016 Offers Ways to Reconcile High-cycling Requirements and Instability at High Temperatures in Resistive RAM December 6th, 2016

Tokyo Institute of Technology research: 3D solutions to energy savings in silicon power transistors December 6th, 2016

Physicists decipher electronic properties of materials in work that may change transistors December 6th, 2016

Infrared instrumentation leader secures exclusive use of Vantablack coating December 5th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Physicists decipher electronic properties of materials in work that may change transistors December 6th, 2016

Construction of practical quantum computers radically simplified: Scientists invent ground-breaking new method that puts quantum computers within reach December 5th, 2016

Shape matters when light meets atom: Mapping the interaction of a single atom with a single photon may inform design of quantum devices December 4th, 2016

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Self Assembly

Computers made of genetic material? HZDR researchers conduct electricity using DNA-based nanowires November 9th, 2016

First multicellular organism inspires the design of better cancer drugs September 15th, 2016

A versatile method to pattern functionalized nanowires: A team of researchers from Hokkaido University has developed a versatile method to pattern the structure of 'nanowires,' providing a new tool for the development of novel nanodevices September 9th, 2016

Location matters in the self-assembly of nanoclusters: Iowa State University scientists have developed a new formulation to explain an aspect of the self-assembly of nanoclusters on surfaces that has broad applications for nanotechnology September 8th, 2016

Nanomedicine

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Journal Nanotechnology Progress International (JONPI) Volume 6, issue 2 coming out soon! December 5th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

Discoveries

Leti IEDM 2016 Paper Clarifies Correlation between Endurance, Window Margin and Retention in RRAM for First Time: Paper Presented at IEDM 2016 Offers Ways to Reconcile High-cycling Requirements and Instability at High Temperatures in Resistive RAM December 6th, 2016

Tokyo Institute of Technology research: 3D solutions to energy savings in silicon power transistors December 6th, 2016

Physicists decipher electronic properties of materials in work that may change transistors December 6th, 2016

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Announcements

Leti IEDM 2016 Paper Clarifies Correlation between Endurance, Window Margin and Retention in RRAM for First Time: Paper Presented at IEDM 2016 Offers Ways to Reconcile High-cycling Requirements and Instability at High Temperatures in Resistive RAM December 6th, 2016

Tokyo Institute of Technology research: 3D solutions to energy savings in silicon power transistors December 6th, 2016

Physicists decipher electronic properties of materials in work that may change transistors December 6th, 2016

Infrared instrumentation leader secures exclusive use of Vantablack coating December 5th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project