Home > Press > Self-Assembling Nanofilaments Enhance Drug Delivery
Abstract:
While most nanoparticles under development as drug delivery vehicles are spheres, a growing body of research suggests that cylindrical nanoparticles would perform even better at the twin goal of surviving in the blood stream long enough to reach their intended target and penetrating the cell wall to deliver their therapeutic payload inside of tumor cells where it is most needed. A team of investigators at the Northwestern University Center of Cancer Nanotechnology Excellence (Northwestern CCNE) has invented a cylindrical nanofilament structure that significantly reduces tumor growth in an animal model of breast cancer.
Self-Assembling Nanofilaments Enhance Drug Delivery
Bethesda, MD | Posted on October 21st, 2012
A team led by Vincent Cryns, who recently moved from Northwestern to the University of Wisconsin School of Medicine and Public Health, and Samuel Stupp, developed the self-assembling nanofibers. The investigators report their findings in the journal ACS Nano.
To create their tumor-inhibiting cylinders, the investigators turned to a family of molecules known as peptide amphiphiles. When put into water, these molecules, which can be made using automated peptide synthesizers, which spontaneously self-assemble into long, thin filaments. Depending on the choice of starting materials, these filaments can display large number of biologically active peptides on their surfaces that enable the fibers to serve as both drugs and drug deliver agents simultaneously without the need to further encapsulate anticancer agents within the nanostructure.
In earlier work, the Northwestern CCNE team had shown that one such nanofiber was more toxic to cancer cells than non-malignant cells, but this nanofiber was degraded rapidly in the blood stream. To improve the pharmacokinetic properties of their nanofiber, the investigators created a second peptide amphiphile, this one linked to poly(ethylene glycol) (PEG), a polymer widely used to increase the survival of nanoparticles in the blood stream. When the researchers mixed the peptide amphiphile with the PEGylated amphiphile, the two molecules together self-assembled into nanofilaments. By adding the PEGylated peptide amphiphile to the mix the investigators increased by eight-fold the amount of intact nanofiber that survived degradation by the enzyme trypsin compared to the original nanofiber.
To see if this nanofiber showed promise in a live animal studies, the investigators administered it to mice with human breast tumors. After dosing the animals twice weekly for three weeks, the researchers observed that the tumors in the treated animals grew much slower than in control animals. They also noted that the animals showed no signs of drug-related toxicities.
####
About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.
The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.
Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.
For more information, please click here
Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580
Copyright © The National Cancer Institute (NCI)
If you have a comment, please
Contact us.
Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Bookmark:
View abstract - “Coassembled cytotoxic and pegylated peptide amphiphiles form filamentous nanostructures with potent antitumor activity in models of breast cancer.”
News and information
Beautiful "flowers" self-assemble in a beaker: Elaborate nanostructures blossom from a chemical reaction perfected at Harvard May 17th, 2013
Artificial Forest for Solar Water-Splitting: Berkeley Lab Researchers Report First Fully Integrated Artificial Photosynthesis Nanosystem May 17th, 2013
Moth-Inspired Nanostructures Take the Color Out of Thin Films May 17th, 2013
NIA Public Briefing: Nanotechnology and the Council of Europe May 17th, 2013
Govt.-Legislation/Regulation/Funding/Policy
Beautiful "flowers" self-assemble in a beaker: Elaborate nanostructures blossom from a chemical reaction perfected at Harvard May 17th, 2013
Artificial Forest for Solar Water-Splitting: Berkeley Lab Researchers Report First Fully Integrated Artificial Photosynthesis Nanosystem May 17th, 2013
Moth-Inspired Nanostructures Take the Color Out of Thin Films May 17th, 2013
NIA Public Briefing: Nanotechnology and the Council of Europe May 17th, 2013
Self Assembly
Beautiful "flowers" self-assemble in a beaker: Elaborate nanostructures blossom from a chemical reaction perfected at Harvard May 17th, 2013
DNA-Guided Assembly Yields Novel Ribbon-Like Nanostructures: Approach could be useful in fabricating new kinds of materials with engineered properties May 16th, 2013
Production of Sensitive Hydrogen Peroxide Biosensor Using Silver Nanoparticles April 26th, 2013
Scientists see nanoparticles form larger structures in real time April 22nd, 2013
Nanomedicine
Nanotechnology could help fight diabetes: Injectable nanogel can monitor blood-sugar levels and secrete insulin when needed May 16th, 2013
Nanobiotix Revenue for the 1st quarter of 2013 May 15th, 2013
Pitt Chemists Demonstrate Nanoscale Alloys So Bright They Could Have Potential Medical Applications: “Think about a particle that will not only help researchers detect cancer sooner but be used to treat the tumor, too.” May 15th, 2013
Using clay to grow bone: Researchers use synthetic silicate to stimulate stem cells into bone cells May 15th, 2013
Discoveries
Beautiful "flowers" self-assemble in a beaker: Elaborate nanostructures blossom from a chemical reaction perfected at Harvard May 17th, 2013
Artificial Forest for Solar Water-Splitting: Berkeley Lab Researchers Report First Fully Integrated Artificial Photosynthesis Nanosystem May 17th, 2013
Moth-Inspired Nanostructures Take the Color Out of Thin Films May 17th, 2013
Scientists capture first direct proof of Hofstadter butterfly effect May 17th, 2013
Announcements
Artificial Forest for Solar Water-Splitting: Berkeley Lab Researchers Report First Fully Integrated Artificial Photosynthesis Nanosystem May 17th, 2013
Moth-Inspired Nanostructures Take the Color Out of Thin Films May 17th, 2013
NIA Public Briefing: Nanotechnology and the Council of Europe May 17th, 2013
Scientists capture first direct proof of Hofstadter butterfly effect May 17th, 2013