Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Protocells – A Versatile Drug Delivery Platform

Abstract:
Imagine it would be possible to transport drugs by a shuttle which would be drawn to the desired destination as if by magic on an invisible thread. Upon arrival, a gate is opened by a specific key and the vehicle can get rid of its precious cargo. This kind of targeted drug delivery would enable controlled and specific enrichment of a therapeutic agent in the tissue or organ where it is actually needed and side effects could be reduced.

Protocells – A Versatile Drug Delivery Platform

Germany | Posted on September 13th, 2012

In traditional drug delivery approaches, only a small amount of the drug reaches the part of the body where it is actually required. It is therefore of the utmost importance to better predict and influence the degree of specificity in targeted drug delivery concepts.

The clinical use of protein toxins like Ricin toxin as anti-cancer agents is often hindered by their immunogenicity which leads to a dosage restriction and represents a significant drawback for their clinical utility. To exploit the valuable features of this class of therapeutic agents, smart and innovative hybrid architectures have to be designed which elegantly circumvent these limitations and fulfill the requirements expected of modern therapeutic agents.

Researchers from the University of New Mexico and from the Sandia National Laboratories present a highly complex system as a versatile delivery platform that may enable protein toxin-based therapies to reach their full potential. The so-called "Protocell" combines a mesoporous silica core loaded with the toxic RTA (Ricin toxin A) with the features of liposomes. The particle core is coated with a lipid bilayer further modified with a targeting peptid for specific delivery, and an endosomolytical peptide for intracellular release.

RTA-loaded protocells show a 500-fold higher capacity for RTA than conventionally loaded liposomes and are stable under neutral pH conditions, unlike the uncoated loaded silica particles or the liposomes which rapidly lose their encapsulated RTA under neutral pH conditions. However, under a slightly acidic pH which reflects the physiological conditions in the endosomal orlysosomal pathway, the total amount of cargo is released within 24 hours.

Due to the coexistence of the endosomolytical and the targeting peptide, only the receptor-positive cells are specifically addressed and killed whereas the viability of other cells is maintained.

Thus, in terms of capacity, stability, and triggered release, these kinds of protocells represent a substantial improvement over conventionally produced liposomes and have the potential to address many limitations of state-of-the-art toxin-based therapies.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Link to the original paper on Wiley Online Library:

Related News Press

News and information

Discovery of nanotubes offers new clues about cell-to-cell communication July 2nd, 2015

Nanospiked bacteria are the brightest hard X-ray emitters July 2nd, 2015

Engineering the world’s smallest nanocrystal July 2nd, 2015

Producing spin-entangled electrons July 2nd, 2015

Nanomedicine

Iranian Scientists Find Simple, Economic Method to Synthesize Antibacterial Nanoparticles July 2nd, 2015

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Carnegie Mellon chemists characterize 3-D macroporous hydrogels: Methods will allow researchers to develop new 'smart' materials June 30th, 2015

Chitosan coated, chemotherapy packed nanoparticles may target cancer stem cells June 30th, 2015

Discoveries

Freezing single atoms to absolute zero with microwaves brings quantum technology closer: Atoms frozen to absolute zero using microwaves July 2nd, 2015

New technology using silver may hold key to electronics advances July 2nd, 2015

Discovery of nanotubes offers new clues about cell-to-cell communication July 2nd, 2015

Nanospiked bacteria are the brightest hard X-ray emitters July 2nd, 2015

Announcements

Nanospiked bacteria are the brightest hard X-ray emitters July 2nd, 2015

Engineering the world’s smallest nanocrystal July 2nd, 2015

Producing spin-entangled electrons July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project