Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Non-Cytotoxic Nanosilver Structures Bring New Hope for Curing Infections

Abstract:
Iranian researchers from Tehran University of Medical Sciences and Stanford University managed to completely eliminate the cytotoxicity of silver nanoparticles, bringing new hopes for curing infections.

Non-Cytotoxic Nanosilver Structures Bring New Hope for Curing Infections

Tehran, Iran | Posted on September 12th, 2012

They first coated silver oxide nanoparticles with a special polymer coating which tends to absorb silver ions and then applied a reducing reagent until a smooth core-shell configuration is achieved. The obtained nanostructure is nontoxic to human cells, in contrast to the conventional silver nanoparticles, and possesses a spectacularly enhanced antibacterial effect.

The unique antibacterial characteristic of silver nanoparticles has attracted a great deal of attention in medical and pharmaceutical applications. However, this promising advantage comes with two major shortcomings: the considerable cytotoxicity of silver nanoparticles on human cells and their inefficiency in fight against bacterial biofilms.

"The serious problem with utilization of silver nanoparticles, their cytotoxic activities, is totally overcome in our proposed nanomaterial. Additionally, the eradication of bacterial biofilms has been made possible," said Dr. Morteza Mahmoudi, the lead researcher and assistant professor of Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences.

"The present engineered multimodal nanoparticles can deeply penetrate into bacterial biofilms and destruct them thanks to their magnetic properties. The highly smooth surface of silver together with the altered composition of the involved corona protein avoids the accumulation of silver nanoparticles in cellular mitochondria. Hence, cytotoxicity is not a matter of concern for the proposed nanostructures," Dr. Mahmoudi added, appreciating his fellow colleague in the project, Dr. Vahid Serpoushan who is with the Stanford University School of Medicine.

The very first idea behind this extensive research was initiated at Dr. Mahmoudi's Laboratory (www.biospion.com) and, in its final form, resulted in a US patent (61604645).

The findings of the mentioned research hold promise for novel practices in fight against certain types of infections and pathogens.

An elaborate report discussing the technical details of this research work has been published in ACS Nano, volume 6, issue 3, 2012, pages 2656 to 2664.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

University of Manchester selects Anasys AFM-IR for coatings and corrosion research July 30th, 2014

Nature inspires a greener way to make colorful plastics July 30th, 2014

Analytical solutions from Malvern Instruments support University of Wisconsin-Milwaukee researchers in understanding environmental effects of nanomaterials July 30th, 2014

FEI Unveils New Solutions for Faster Time-to-Analysis in Metals Research July 30th, 2014

Nanomedicine

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

New imaging agent provides better picture of the gut July 25th, 2014

Discoveries

Flexible Metamaterial Absorbers July 29th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

Announcements

University of Manchester selects Anasys AFM-IR for coatings and corrosion research July 30th, 2014

Nature inspires a greener way to make colorful plastics July 30th, 2014

Analytical solutions from Malvern Instruments support University of Wisconsin-Milwaukee researchers in understanding environmental effects of nanomaterials July 30th, 2014

FEI Unveils New Solutions for Faster Time-to-Analysis in Metals Research July 30th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE