Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Non-Cytotoxic Nanosilver Structures Bring New Hope for Curing Infections

Abstract:
Iranian researchers from Tehran University of Medical Sciences and Stanford University managed to completely eliminate the cytotoxicity of silver nanoparticles, bringing new hopes for curing infections.

Non-Cytotoxic Nanosilver Structures Bring New Hope for Curing Infections

Tehran, Iran | Posted on September 12th, 2012

They first coated silver oxide nanoparticles with a special polymer coating which tends to absorb silver ions and then applied a reducing reagent until a smooth core-shell configuration is achieved. The obtained nanostructure is nontoxic to human cells, in contrast to the conventional silver nanoparticles, and possesses a spectacularly enhanced antibacterial effect.

The unique antibacterial characteristic of silver nanoparticles has attracted a great deal of attention in medical and pharmaceutical applications. However, this promising advantage comes with two major shortcomings: the considerable cytotoxicity of silver nanoparticles on human cells and their inefficiency in fight against bacterial biofilms.

"The serious problem with utilization of silver nanoparticles, their cytotoxic activities, is totally overcome in our proposed nanomaterial. Additionally, the eradication of bacterial biofilms has been made possible," said Dr. Morteza Mahmoudi, the lead researcher and assistant professor of Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences.

"The present engineered multimodal nanoparticles can deeply penetrate into bacterial biofilms and destruct them thanks to their magnetic properties. The highly smooth surface of silver together with the altered composition of the involved corona protein avoids the accumulation of silver nanoparticles in cellular mitochondria. Hence, cytotoxicity is not a matter of concern for the proposed nanostructures," Dr. Mahmoudi added, appreciating his fellow colleague in the project, Dr. Vahid Serpoushan who is with the Stanford University School of Medicine.

The very first idea behind this extensive research was initiated at Dr. Mahmoudi's Laboratory (www.biospion.com) and, in its final form, resulted in a US patent (61604645).

The findings of the mentioned research hold promise for novel practices in fight against certain types of infections and pathogens.

An elaborate report discussing the technical details of this research work has been published in ACS Nano, volume 6, issue 3, 2012, pages 2656 to 2664.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Pulses of electrons manipulate nanomagnets and store information: Scientists use electron pulses to create and manipulate nanoscale magnetic excitations that can store data July 21st, 2017

The first light atomic nucleus with a second face July 20th, 2017

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Nanomedicine

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Probiotics: Novel biosynthetic tool to develop metallic nanoparticles: This research article by Dr. Nida Akhtar et al has been published in Recent Patents on Drug Delivery & Formulation, Volume 11, Issue 1, 2017 July 20th, 2017

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

'Upconverted' light has a bright future: Rice University professor developing plasmon-powered devices for medicine, security, solar cells July 17th, 2017

Discoveries

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Pulses of electrons manipulate nanomagnets and store information: Scientists use electron pulses to create and manipulate nanoscale magnetic excitations that can store data July 21st, 2017

The first light atomic nucleus with a second face July 20th, 2017

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Announcements

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Pulses of electrons manipulate nanomagnets and store information: Scientists use electron pulses to create and manipulate nanoscale magnetic excitations that can store data July 21st, 2017

The first light atomic nucleus with a second face July 20th, 2017

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project