Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Non-Cytotoxic Nanosilver Structures Bring New Hope for Curing Infections

Abstract:
Iranian researchers from Tehran University of Medical Sciences and Stanford University managed to completely eliminate the cytotoxicity of silver nanoparticles, bringing new hopes for curing infections.

Non-Cytotoxic Nanosilver Structures Bring New Hope for Curing Infections

Tehran, Iran | Posted on September 12th, 2012

They first coated silver oxide nanoparticles with a special polymer coating which tends to absorb silver ions and then applied a reducing reagent until a smooth core-shell configuration is achieved. The obtained nanostructure is nontoxic to human cells, in contrast to the conventional silver nanoparticles, and possesses a spectacularly enhanced antibacterial effect.

The unique antibacterial characteristic of silver nanoparticles has attracted a great deal of attention in medical and pharmaceutical applications. However, this promising advantage comes with two major shortcomings: the considerable cytotoxicity of silver nanoparticles on human cells and their inefficiency in fight against bacterial biofilms.

"The serious problem with utilization of silver nanoparticles, their cytotoxic activities, is totally overcome in our proposed nanomaterial. Additionally, the eradication of bacterial biofilms has been made possible," said Dr. Morteza Mahmoudi, the lead researcher and assistant professor of Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences.

"The present engineered multimodal nanoparticles can deeply penetrate into bacterial biofilms and destruct them thanks to their magnetic properties. The highly smooth surface of silver together with the altered composition of the involved corona protein avoids the accumulation of silver nanoparticles in cellular mitochondria. Hence, cytotoxicity is not a matter of concern for the proposed nanostructures," Dr. Mahmoudi added, appreciating his fellow colleague in the project, Dr. Vahid Serpoushan who is with the Stanford University School of Medicine.

The very first idea behind this extensive research was initiated at Dr. Mahmoudi's Laboratory (www.biospion.com) and, in its final form, resulted in a US patent (61604645).

The findings of the mentioned research hold promise for novel practices in fight against certain types of infections and pathogens.

An elaborate report discussing the technical details of this research work has been published in ACS Nano, volume 6, issue 3, 2012, pages 2656 to 2664.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Renishaw receives Queen's Award for spectroscopy developments November 25th, 2014

JPK reports on the use of AFM and the CellHesion module to study plant cells at the University of Queensland November 25th, 2014

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research yields material made of single-atom layers that snap together like Legos November 25th, 2014

Nanomedicine

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research reveals how our bodies keep unwelcome visitors out of cell nuclei November 24th, 2014

ASU, IBM move ultrafast, low-cost DNA sequencing technology a step closer to reality November 24th, 2014

An Inside Job: UC-Designed Nanoparticles Infiltrate, Kill Cancer Cells From Within November 24th, 2014

Discoveries

Lawrence Livermore researchers develop efficient method to produce nanoporous metals November 25th, 2014

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research yields material made of single-atom layers that snap together like Legos November 25th, 2014

Blu-ray disc can be used to improve solar cell performance: Data storage pattern transferred to solar cell increases light absorption November 25th, 2014

Announcements

Renishaw receives Queen's Award for spectroscopy developments November 25th, 2014

JPK reports on the use of AFM and the CellHesion module to study plant cells at the University of Queensland November 25th, 2014

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research yields material made of single-atom layers that snap together like Legos November 25th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE