Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Polymer Nanoparticle Overcomes Anticancer Drug Resistance

Abstract:
In a nanotechnology two-for-one, researchers at the Johns Hopkins University Center of Cancer Nanotechnology Excellence (Hopkins CCNE) have created a polymer nanoparticle that overcomes tumor resistance to the common anticancer agent doxorubicin and that protects the heart against drug-triggered damage, a therapy-ending side effect that limits doxorubicin's effectiveness. This novel nanoparticle incorporates both doxorubicin and curcumin, a major component of the bright yellow spice turmeric.

Polymer Nanoparticle Overcomes Anticancer Drug Resistance

Bethesda, MD | Posted on August 21st, 2012

This work was led by Anirban Maitra, a principal investigator in the Hopkins CCNE. Dr. Maitra and his colleagues published the results of their work in the journal Oncotarget.

Numerous studies over the past few years have shown that high doses of curcumin can overcome the resistance to multiple anticancer agents that many, if not most, tumors develop over time. Curcumin, however, is poorly soluble in the blood stream and as a result, getting high enough levels of this agent to tumors has proven challenging. Dr. Maitra's approach to solving this problem has been to use polymer nanoparticles to deliver curcumin to tumors. He and his colleagues have published several papers over the past two years describing the development and behavior of their curcumin-nanoparticle formulation and its ability to make drug-resistant tumors susceptible to chemotherapy.

In their current paper, the investigators discuss how they prepared a polymer nanoparticle containing both curcumin and doxorubicin. Both in vitro and animal tests demonstrated that this formulation had striking anticancer activity in models of multiple myeloma, leukemia, and prostate and ovarian cancers. Perhaps equally important, the animals treated with the nanoparticle did not experience any cardiac toxicity or bone marrow suppression, even at cumulative doses that normally trigger cardiac toxicity by free doxorubicin or liposome-encapsulated doxorubicin, which was the first nanoparticle drug approved for use in treating cancer in humans and is widely used in treating breast cancer. Further examination of the heart-protecting characteristics of this formulation showed that encapsulating doxorubicin in a polymer nanoparticle spared heart muscle cells from oxidative stress normally triggered by doxorubicin.

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

- View abstract “A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy.”

Related News Press

News and information

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

PETA science consortium to present hazard testing strategy at nanotoxicology meeting: High tech field ripe for use of sophisticated non-animal testing strategies April 22nd, 2014

Harris & Harris Group Notes the Receipt of Proceeds From the Sale of Molecular Imprints' Semiconductor Business to Canon April 22nd, 2014

National Space Society Congratulates SpaceX on the Success of CRS-3 and the First Flight of the Falcon 9R April 22nd, 2014

Govt.-Legislation/Regulation/Funding/Policy

Cloaked DNA nanodevices survive pilot mission: Successful foray opens door to virus-like DNA nanodevices that could diagnose diseased tissues and manufacture drugs to treat them April 22nd, 2014

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

Progress made in developing nanoscale electronics: New research directs charges through single molecules April 21st, 2014

'Exotic' material is like a switch when super thin April 18th, 2014

Nanomedicine

Cloaked DNA nanodevices survive pilot mission: Successful foray opens door to virus-like DNA nanodevices that could diagnose diseased tissues and manufacture drugs to treat them April 22nd, 2014

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

Amino-functionalized carbon nanotubes act as a carrier for nerve growth factor April 21st, 2014

Newly-Produced Bone Cement Able to Carry Medicine April 21st, 2014

Discoveries

Like a hall of mirrors, nanostructures trap photons inside ultrathin solar cells April 22nd, 2014

Nanomaterial Outsmarts Ions April 22nd, 2014

Vacuum Ultraviolet Lamp of the Future Created in Japan: First Solid-State Vacuum UV Phosphor, Described in APL-Materials, Promises Smaller, Safer, Longer Lasting, Low Power Lamps for Industrial Applications April 22nd, 2014

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

Announcements

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

PETA science consortium to present hazard testing strategy at nanotoxicology meeting: High tech field ripe for use of sophisticated non-animal testing strategies April 22nd, 2014

Harris & Harris Group Notes the Receipt of Proceeds From the Sale of Molecular Imprints' Semiconductor Business to Canon April 22nd, 2014

National Space Society Congratulates SpaceX on the Success of CRS-3 and the First Flight of the Falcon 9R April 22nd, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE