Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Gold Nanorods Hitch Ride on Immune Cells that Target Breast Tumors

Abstract:
One of the challenges in treating cancer, whether using nanotechnology or not, is that tumors can often be inaccessible to the therapies designed to kill them. Mostafa El-Sayed, of the Georgia Institute of Technology, and his colleagues are attempting to overcome this obstacle by designing drug-loaded gold nanorods that attract the attention of tumor-associated immune cells known as macrophages. The researchers believe that these macrophages will then deliver the nanorods to the tumors, crossing the normally impermeable blood-brain barrier to do so.

Gold Nanorods Hitch Ride on Immune Cells that Target Breast Tumors

Bethesda, MD | Posted on August 21st, 2012

Dr. El-Sayed, who is a co-principal investigator of a Cancer Nanotechnology Platform Partnership held jointly by Georgia Tech and Emory University, and his colleagues have synthesized gold nanorods that target tumor-associated macrophages. The investigators have published the initial results of their work in the journal Small.

To attract the attention of tumor-associated macrophages, Dr. El-Sayed's team coated them with an antibiotic belonging to a family of molecules called macrolides. These broad-spectrum antibiotics are known to accumulate at very high concentrations inside macrophages. Therefore, when macrolide-coated nanorods were added to macrophages growing in culture along with breast tumor cells, the macrophages quickly took up the nanorods. When the investigators then irradiated the nanorod-loaded macrophages with light from a near-infrared laser, they found that the co-cultured breast tumor cells, which were not directly exposed to the nanorods, were killed. The researchers hypothesize that the light-activated gold nanorods enhanced the innate tumor-killing activity of the macrophages.

The investigators note that "the ability of tumor-associated macrophages to migrate freely in circulation, bypass the blood-brain barrier, and preferentially accumulate and infiltrate into solid tumors make macrolide-functionalized gold nanoparticles promising candidates for targeted cancer drug delivery to breast and brain tumors." They also hypothesize that this type of therapy could operate synergistically with conventional chemotherapy.

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Small molecule-gold nanorod conjugates selectively target and induce macrophage cytotoxicity towards breast cancer cells.”

Related News Press

Govt.-Legislation/Regulation/Funding/Policy

Collaboration yields discovery of 12-sided silica cages June 20th, 2018

Powering the 21st Century with Integrated Photonics: UCSB-Led Team Selected for Demonstration of a Novel Waveguide Platform Which is Transparent Throughout the MWIR and LWIR Spectral Bands June 19th, 2018

Carbon nanotube optics poised to provide pathway to optical-based quantum cryptography and quantum computing: Researchers are exploring enhanced potential of carbon nanotubes for unique applications June 18th, 2018

Camouflaged nanoparticles used to deliver killer protein to cancer June 17th, 2018

Nanomedicine

Collaboration yields discovery of 12-sided silica cages June 20th, 2018

JPK talks with Dr Frank Lafont, Director of the BioImaging Center Lille (BICeL) about the use of the NanoWizard® AFM together with fluorescence microscopy in the study of living cells June 19th, 2018

Camouflaged nanoparticles used to deliver killer protein to cancer June 17th, 2018

Graphene carpets: So neurons communicate better: Research by SISSA reveals that graphene can strengthen neuronal activity, confirming the unique properties of this nanomaterial. The study has been published on Nature Nanotechnology June 13th, 2018

Discoveries

Collaboration yields discovery of 12-sided silica cages June 20th, 2018

Carbon nanotube optics poised to provide pathway to optical-based quantum cryptography and quantum computing: Researchers are exploring enhanced potential of carbon nanotubes for unique applications June 18th, 2018

Camouflaged nanoparticles used to deliver killer protein to cancer June 17th, 2018

Squeezing light at the nanoscale: Ultra-confined light could detect harmful molecules June 17th, 2018

Announcements

Collaboration yields discovery of 12-sided silica cages June 20th, 2018

JPK talks with Dr Frank Lafont, Director of the BioImaging Center Lille (BICeL) about the use of the NanoWizard® AFM together with fluorescence microscopy in the study of living cells June 19th, 2018

Powering the 21st Century with Integrated Photonics: UCSB-Led Team Selected for Demonstration of a Novel Waveguide Platform Which is Transparent Throughout the MWIR and LWIR Spectral Bands June 19th, 2018

Executives Explore Key Megatrends and Innovations in MEMS, Sensors, Imaging Tech at SEMI-MSIG European Summits: Speakers to share developments in smart automotive, smart cities, smart industrial, biomedical, consumer and IoT, September 19-21, 2018 in Grenoble, France June 19th, 2018

Patents/IP/Tech Transfer/Licensing

Tunable diamond string may hold key to quantum memory: A process similar to guitar tuning improves storage time of quantum memory May 24th, 2018

Self-assembling 3D battery would charge in seconds May 22nd, 2018

Leti Silicon Photonics Design Kit Available in Synopsis OptoDesigner Suite: Kit Contains Design Rules and Building Blocks for Multi-Project Wafers And Custom Runs on Leti’s Si310 Platform April 5th, 2018

NTU scientists create customizable, fabric-like power source for wearable electronics January 30th, 2018

Alliances/Trade associations/Partnerships/Distributorships

Powering the 21st Century with Integrated Photonics: UCSB-Led Team Selected for Demonstration of a Novel Waveguide Platform Which is Transparent Throughout the MWIR and LWIR Spectral Bands June 19th, 2018

Leti and Cellmic Join Forces to Speed Market Adoption of Lens-Free Imaging and Sensing Techniques May 3rd, 2018

Nanobiotix and Weill Cornell Medicine Partner on Pre-Clinical Research Inbox x May 3rd, 2018

New era in high field superconducting magnets – opening new frontiers in science, nanotechnology and materials discovery January 9th, 2018

Research partnerships

Powering the 21st Century with Integrated Photonics: UCSB-Led Team Selected for Demonstration of a Novel Waveguide Platform Which is Transparent Throughout the MWIR and LWIR Spectral Bands June 19th, 2018

Evidence for a new property of quantum matter revealed: Electrical dipole activity detected in a quantum material unlike any other tested June 11th, 2018

Scientists use photonic chip to make virtual movies of molecular motion June 6th, 2018

Quantum Interference May Be Key to Smaller Insulators: Breakthrough could jumpstart further miniaturization of transistors June 6th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project