Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > UCF nanoparticle discovery opens door for pharmaceuticals

What a University of Central Florida student thought was a failed experiment has led to a serendipitous discovery hailed by some scientists as a potential game changer for the mass production of nanoparticles. Soroush Shabahang, a graduate student in CREOL (The College of Optics & Photonics), made the finding that could ultimately change the way pharmaceuticals are produced and delivered.

Credit: UCF
What a University of Central Florida student thought was a failed experiment has led to a serendipitous discovery hailed by some scientists as a potential game changer for the mass production of nanoparticles. Soroush Shabahang, a graduate student in CREOL (The College of Optics & Photonics), made the finding that could ultimately change the way pharmaceuticals are produced and delivered.

Credit: UCF

Abstract:
What a University of Central Florida student thought was a failed experiment has led to a serendipitous discovery hailed by some scientists as a potential game changer for the mass production of nanoparticles.

UCF nanoparticle discovery opens door for pharmaceuticals

Orlando, FL | Posted on August 7th, 2012

Soroush Shabahang, a graduate student in CREOL (The College of Optics & Photonics), made the finding that could ultimately change the way pharmaceuticals are produced and delivered.

The discovery was based on using heat to break up long, thin fibers into tiny, proportionally sized seeds, which have the capability to hold multiple types of materials locked in place. The work, published in the July 18 issue of Nature, opens the door to a world of applications.

Craig Arnold, associate professor of Mechanical and Aerospace Engineering at Princeton University and an expert in laser material interactions who did not work on the project, said no one else in the field has been able to accomplish that feat.

With a new non-chemical method of creating identical particles of any size in large quantities, "the possible applications are up to your imagination," Arnold said.

The most immediate prospect is the creation of particles capable of drug delivery that could, for example, combine different agents for fighting a tumor. Or it could combine a time-release component with medications that will only activate once they reach their target - infected cells.

"With this approach you can make a very sophisticated structure with no more effort than creating the simplest of structures," said Ayman Abouraddy, an assistant professor at CREOL and Shabahang's mentor and advisor. Abouraddy has spent his career, first at the Massachusetts Institute of Technology and now at UCF, studying the fabrication of multimaterial fibers.

The technique relies on heat to break molten fibers into spherical droplets. Imagine water dripping from a faucet. Glass fibers are perhaps best known as the cylindrical cables that transmit digital information over long distances. For year, scientists have been looking for ways to improve the purity of glass fibers to allow for faster, disruption-free transmission of light waves.

Shabahang and fellow graduate student Joshua Kaufman were working on just such a project, heating and stretching glass fiber on a homemade tapering machine. Shabahang noticed that instead of the desired result of making the center of the cable thinner, the material actually broke apart into multiple miniature spheres.

"It was kind of a failure to me," Shabahang said.

However, when Abouraddy heard what had happened he knew right away that this "mistake" was a major breakthrough.

While at MIT, Abouraddy and his mentor, Yoel Fink, a professor of materials science and current director of MIT's Research Laboratory of Electronics, said they were told by a theoretician that molten optical fiber should align with a process known as Rayleigh instability, which explains what causes a falling stream of fluid to break into droplets.

At the time, the MIT group was focused on producing fibers containing multiple materials. The team produced fibers by heating a scale model called a "preform" and stretching it apart much the way taffy is made. The process is known as thermal drawing.

Shabahang's experiment shows that by heating and then cooling multimaterial fibers, the theoretical became reality. Uniform particles that look like droplets are produced. Moreover, Shabahang demonstrated that once the spheres form, additional materials can be added and locked into place like LEGO building blocks, resulting in particles with sophisticated internal structures.

Especially significant is the creation of "beach ball" particles consisting of two different materials melded together in alternating fashion, similar to the stripes on a beach ball.

Kaufman, Shabahang and Abouraddy contributed to the Nature article in addition to Guangming Tao from CREOL, UCF; Esmaeil-Hooman Banaei from the Department of Electrical Engineering & Computer Science, UCF; Daosheng S. Deng, Department of Chemical Engineering, MIT; Xiangdong Liang, Department of Mathematics, MIT; Steven G. Johnson, Department of Mathematics, MIT; and Yoel Fink from MIT.

Some of the funding for the project was made available by the National Science Foundation, the Oak Ridge Associated Universities through a Ralph E. Powe Junior Faculty Enhancement Award, and the Air Force Office of Scientific Research.

####

For more information, please click here

Contacts:
Barbara Abney
407-823-5139

Copyright © University of Central Florida

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

The Nature paper is available here:

Related News Press

News and information

Feynman Prize Winners Announced! April 26th, 2015

New ASTM Standards Will Help Educate Present and Future Nanotechnology Workforces April 26th, 2015

Heat makes electrons’ spin in magnetic superconductors April 26th, 2015

QD Vision Wins 2015 Bronze Edison Award for Color IQ™ Quantum Dot Technology April 26th, 2015

Govt.-Legislation/Regulation/Funding/Policy

SEFCU, SUNY Poly CNSE Announce Winning Student-Led Teams in the 6th Annual $500,000 New York Business Plan Competition April 25th, 2015

Northwestern scientists develop first liquid nanolaser: Technology could lead to new way of doing 'lab on a chip' medical diagnostics April 25th, 2015

ORNL reports method that takes quantum sensing to new level April 23rd, 2015

Electron spin brings order to high entropy alloys April 23rd, 2015

Nanomedicine

Northwestern scientists develop first liquid nanolaser: Technology could lead to new way of doing 'lab on a chip' medical diagnostics April 25th, 2015

Nanotech-enabled moisturizer speeds healing of diabetic skin wounds: Spherical nucleic acids silence gene that interferes with wound healing April 24th, 2015

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

A silver lining: UCSB researchers cradle silver nanoclusters inside synthetic DNA to create a programmed, tunable fluorescent array April 23rd, 2015

Discoveries

Heat makes electrons’ spin in magnetic superconductors April 26th, 2015

SEFCU, SUNY Poly CNSE Announce Winning Student-Led Teams in the 6th Annual $500,000 New York Business Plan Competition April 25th, 2015

Northwestern scientists develop first liquid nanolaser: Technology could lead to new way of doing 'lab on a chip' medical diagnostics April 25th, 2015

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

Announcements

Feynman Prize Winners Announced! April 26th, 2015

New ASTM Standards Will Help Educate Present and Future Nanotechnology Workforces April 26th, 2015

Heat makes electrons’ spin in magnetic superconductors April 26th, 2015

QD Vision Wins 2015 Bronze Edison Award for Color IQ™ Quantum Dot Technology April 26th, 2015

Military

Electron spin brings order to high entropy alloys April 23rd, 2015

Engineer improves rechargeable batteries with MoS2 nano 'sandwich' April 18th, 2015

Cobalt film a clean-fuel find: Rice University discovery is efficient, robust at drawing hydrogen and oxygen from water April 15th, 2015

MIT sensor detects spoiled meat: Tiny device could be incorporated into 'smart packaging' to improve food safety April 15th, 2015

Photonics/Optics/Lasers

Northwestern scientists develop first liquid nanolaser: Technology could lead to new way of doing 'lab on a chip' medical diagnostics April 25th, 2015

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

ORNL reports method that takes quantum sensing to new level April 23rd, 2015

Quantum 'paparazzi' film photons in the act of pairing up April 22nd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project