Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Zeroing in on the Best Shape for Cancer-Fighting Nanoparticles

Abstract:
As the field of nanomedicine matures, an emerging point of contention has been what shape nanoparticles deliver their drug or DNA payloads most effectively. A pair of publications from a team led by Paulo Decuzzi of the Texas Center for Cancer Nanomedicine suggests these microscopic workhorses ought to be disc-shaped, not spherical or rod-shaped, when targeting cancers at or near blood vessels.

Zeroing in on the Best Shape for Cancer-Fighting Nanoparticles

Bethesda, MD | Posted on July 2nd, 2012

"The vast majority, maybe 99 percent, of the work being done right now is using nanoparticles that are spherical," said Dr. Decuzzi. "But evidence is showing there may be better ways to get chemotherapy drugs to the site of a vascularizing cancer."

Despite their popularity, there are problems with sphere-shaped nanoparticles. First, they are relatively small, which limits the amount of drug they can deliver when they reach their target. In addition, they are more likely to get pushed downstream by blood's powerful flow instead of sticking to their target tissue.

"The small surface exposed by spherical nanoparticles to the blood vessel walls - theoretically a single point - in the tumor tissue cannot support stable, firm adhesion and they are easily washed away. This hampers their effective accumulation within the diseased tissue," explained Dr. Decuzzi. "So a number of laboratories have been asking, how can we maximize the accumulation of nanoparticles in the diseased tissues? Is there a better shape?"

In the journal Biomaterials, Decuzzi and his colleagues, including Texas Center for Cancer Nanotechnology principal investigator Mauro Ferrari, show that at biologically relevant flow speeds, disc-shaped nanoparticles were less likely to get pushed off their targets than rod-shaped nanoparticles -- another shape previously proposed as an alternative to spheres. The ideal size was 1,000 in diameter by 400 nanometers thick. The experiments were conducted in vitro and confirmed by computational modeling.

To create these nanodiscs, the Methodist nanomedicine group used photolithographic technology, the same tools used to make the tiniest components in computers. Photolithography allowed the investigators to specify the size, shape, and surface properties of the nanoparticles with a great deal of accuracy. The nanoparticles were constructed with sponge-like holes through them, creating niches into which drugs are loaded. Using photolithography enables the researchers to can change the size, shape, and surface properties of the particles independently.

The nanoparticles are made of silica, and biologically relevant molecules are later attached to the outside to improve binding to target cells and to delay destruction by the immune system. Silicon has an extremely low toxicity profile at the doses typically used in humans and animal models. Dr. Decuzzi said silica nanoparticles are readily broken down and removed from the body within 24 to 48 hours.

In a second paper, published in the Journal of Controlled Release, the Texas team used mouse models to show that 1,000 by 400 nm disc-shaped nanoparticles bind more readily to and near melanoma cells than spherical particles. The researchers also showed that the 1000 by 400 nm discs were less likely than smaller or larger discs, or rods, to end up in the liver.

"These two papers are the culmination of eight years of work, looking at the properties of disc-, rod-, and spherical nanoparticles in computer simulations, in vitro, and then in vivo," Dr. Decuzzi said. "What has been most rewarding is that all the important things we predicted via mathematical models turned out to be true in real-life experiments. We are getting close to answering crucial questions about what these nanoparticles need to look like."

Dr. Decuzzi says his group will continue working on the optimization of nanoparticles and, in particular, will be looking at what he calls the "4S" problem. After establishing the right size, shape, and surface chemistry, Decuzzi says he wants to see if the right amount of stiffness, or flexibility, can further enhance the in vivo performance of nanoparticles.

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View Biomaterials abstract - "Size and shape effects in the biodistribution of intravascularly injected particles."

View Journal of Controlled Release abstract - "The preferential targeting of the diseased microvasculature by disk-like particles."

Related News Press

News and information

Advantest to Exhibit at SEMICON Korea in Seoul, South Korea February 4-6 Showcasing Broad Portfolio of Semiconductor Products, Technologies and Solutions January 29th, 2015

Park Systems Announces Innovations in Bio Cell Analysis with the Launch of Park NX-Bio, the only 3-in-1 Imaging Nanoscale Tool Available for Life Science Researchers January 29th, 2015

2015 Nanonics Image Contest January 29th, 2015

Iranian Scientists Use MOFs to Eliminate Dye Pollutants January 29th, 2015

Govt.-Legislation/Regulation/Funding/Policy

Nanoscale Mirrored Cavities Amplify, Connect Quantum Memories: Advance could lead to quantum computing and the secure transfer of information over long-distance fiber optic networks January 28th, 2015

Detecting chemical weapons with a color-changing film January 28th, 2015

'Bulletproof' battery: Kevlar membrane for safer, thinner lithium rechargeables January 28th, 2015

Researchers Make Magnetic Graphene: UC Riverside research could lead to new multi-functional electronic devices January 27th, 2015

Nanomedicine

Made-in-Singapore rapid test kit detects dengue antibodies from saliva: IBN's MedTech innovation simplifies diagnosis of infectious diseases January 29th, 2015

Iranian Researchers Planning to Produce Edible Insulin January 28th, 2015

Nanoparticles that deliver oligonucleotide drugs into cells described in Nucleic Acid Therapeutics January 28th, 2015

Nanoliposomes Help Efforts to Cure Bacterial Infections January 27th, 2015

Discoveries

Creating new materials with quantum effects for electronics January 29th, 2015

Los Alamos Develops New Technique for Growing High-Efficiency Perovskite Solar Cells: Researchers’ crystal-production insights resolve manufacturing difficulty January 29th, 2015

Iranian Scientists Use MOFs to Eliminate Dye Pollutants January 29th, 2015

Made-in-Singapore rapid test kit detects dengue antibodies from saliva: IBN's MedTech innovation simplifies diagnosis of infectious diseases January 29th, 2015

Announcements

Advantest to Exhibit at SEMICON Korea in Seoul, South Korea February 4-6 Showcasing Broad Portfolio of Semiconductor Products, Technologies and Solutions January 29th, 2015

Park Systems Announces Innovations in Bio Cell Analysis with the Launch of Park NX-Bio, the only 3-in-1 Imaging Nanoscale Tool Available for Life Science Researchers January 29th, 2015

2015 Nanonics Image Contest January 29th, 2015

Iranian Scientists Use MOFs to Eliminate Dye Pollutants January 29th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE