Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Stony Brook University Researchers Develop Groundbreaking New Graphene-Based MRI Contrast Agent

Balaji Sitharaman, PhD
Balaji Sitharaman, PhD

Abstract:
Dr. Balaji Sitharaman, PhD, an Assistant Professor in the Department of Biomedical Engineering at Stony Brook University, and a team of researchers developed a new, highly efficacious, potentially safer and more cost effective nanoparticle-based MRI (magnetic resonance imaging) contrast agent for improved disease diagnosis and detection. The most recent findings are discussed in detail in his team's research paper "Physicochemical characterization, and relaxometry studies of micro-graphite oxide, graphene nanoplatelets, and nanoribbons," published in the June 7 edition of the journal PLoS ONE.

Stony Brook University Researchers Develop Groundbreaking New Graphene-Based MRI Contrast Agent

Stony Brook, NY | Posted on June 7th, 2012

The MRI, the technology for which was invented at Stony Brook University by Professor Paul Lauterbur, is one of the most powerful and central techniques in diagnostic medicine and biomedical research used primarily to render anatomical details for improved diagnosis of many pathologies and diseases. Currently, most MRI procedures use gadolinium-based contrast agents to improve the visibility and definition of disease detection. However, recent studies have shown harmful side effects, such as nephrogenic systemic fibrosis, stemming from the use of this contrast agent in some patients, forcing the Food and Drug Administration (FDA) to place restrictions on the clinical use of gadolinium. Further, most MRI contrast agents are not suitable for extended-residence-intravascular (blood pool), or tissue (organ)-specific imaging, and do not allow molecular imaging.

To address the need for an MRI contrast agent that demonstrates greater effectiveness and lower toxicity, Dr. Sitharaman developed a novel high-performance graphene-based contrast agent that may replace the gadolinium-based agent which is widely used by physicians today. "A graphene-based contrast agent can allow the same clinical MRI performance at substantially lower dosages," said Dr. Sitharaman. The project is a Wallace H. Coulter Foundation Translational Research Award winner and the recipient of a two-year translational grant to study preclinical safety and efficacy.

"The technology will lower health care costs by reducing the cost per dose as well as the number of doses required," noted Dr. Sitharaman. "Further, since this new MRI contrast agent will substantially improve disease detection by increasing sensitivity and diagnostic confidence, it will enable earlier treatment for many diseases, which is less expensive, and of course more effective for diseases such as cancer."

The new graphene-based imaging contrast agent is also the focus of Dr. Sitharaman's start-up company, Theragnostic Technologies, Inc., which was incorporated in early 2012. The ongoing development of this technology is supported by industry expert and business advisor, Shahram Hejazi, and clinical experts Kenneth Shroyer, MD, PhD, Professor and Chair, Department of Pathology, Stony Brook University, and William Moore, MD, Chief of Thoracic Imaging, and Assistant Professor, Department of Radiology, Stony Brook University. Co-authors of the article include Department of Biomedical Engineering research assistants Bhavna Paratala, Barry Jacobson and Shruti Kanakia; and Leonard Deepak Francis from the International Iberian Nanotechnology Laboratory in Portugal.

Dr. Sitharaman's research team focuses their interests at the interface of bionanotechnology, regenerative and molecular medicine. They seek to "synergize" the advancements in each of these fields to develop a dynamic research program that tackles problems related to the diagnosis and treatment of disease and tissue regeneration. Dr. Sitharaman received his BS with Honors from the Indian Institute of Technology and his PhD from Rice University, where he also completed his postdoctoral work as a J. Evans Attwell-Welch Postdoctoral Fellowship recipient.

####

For more information, please click here

Contacts:
Stony Brook University Office of Media Relations
631.632.6310

Copyright © Newswise

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Controlling phase changes in solids: Controlling phase changes in solids July 29th, 2015

Liquipel Debuts Eyesight-Saving ION-Glass Blue Light Protection for iPhones and Androids at RadioShack Stores Nationwide: Liquipel's Unique Protective Screen, Available at RadioShack, Cuts Harmful Blue Light Implicated in Macular Degeneration by 10x July 28th, 2015

Nanophase to present paper on slurry pH impact at Optics + Photonics conference July 28th, 2015

Laboratorial Performance of Nanocomposite Membrane Improved in Water Purification July 28th, 2015

Imaging

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

Reshaping the solar spectrum to turn light to electricity: UC Riverside researchers find a way to use the infrared region of the sun's spectrum to make solar cells more efficient July 27th, 2015

Superfast fluorescence sets new speed record: Plasmonic device has speed and efficiency to serve optical computers July 27th, 2015

Ultra-thin hollow nanocages could reduce platinum use in fuel cell electrodes July 24th, 2015

The University of California, Los Angeles (UCLA), USA, combines Raman microscopy with scanning electron microscopy (SEM) to study archaeological textiles and fibres July 22nd, 2015

Graphene

Stretching the limits on conducting wires July 25th, 2015

More efficient process to produce graphene developed by Ben-Gurion University researchers July 23rd, 2015

Nanomedicine

Stretching the limits on conducting wires July 25th, 2015

UT Dallas nanotechnology research leads to super-elastic conducting fibers July 24th, 2015

Nanopaper as an optical sensing platform July 23rd, 2015

Albany College of Pharmacy and Health Sciences to Host One Week Symposium on Nanomedicine July 23rd, 2015

Discoveries

Controlling phase changes in solids: Controlling phase changes in solids July 29th, 2015

New computer model could explain how simple molecules took first step toward life: Two Brookhaven researchers developed theoretical model to explain the origins of self-replicating molecules July 28th, 2015

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

'Seeing' molecular interactions could give boost to organic electronics July 28th, 2015

Announcements

Controlling phase changes in solids: Controlling phase changes in solids July 29th, 2015

Perfect Optical Properties in Production of Aluminum Oxide Colloid Nanoparticles July 28th, 2015

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

'Seeing' molecular interactions could give boost to organic electronics July 28th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project