Home > Press > Using chitosan core-shell nanoparticle for breast cancer treatment
Abstract:
Researchers at National Nanotechnology Center (NANOTEC) and King Mongkut's University of Technology Thonburi (KMUTT) have successfully developed a target drug delivery system using folate-conjugated pluronic F127/chitosan core-shell nanoparticles to deliver doxorubicin (DOX) to target cancer cells focusing on breast cancer.
Using chitosan core-shell nanoparticle for breast cancer treatment
Pathumthani, Thailand | Posted on May 31st, 2012
"DOX is one of the most commonly used chemotherapeutic agents for cancer treatment including breast cancer. However, DOX is also considered a poor soluble drug that is toxic to healthy tissues" said Dr. Nuttaporn Pimpha, a NANOTEC researcher at Hybrid Nanostructure and Nanocomposite. "By using core-shell nanoparticles from folate-conjugated pluronic F127/chitosan we were able to develop a delivery vector that has greater targeting ability, chemical stability and lower cytotoxicity".
As in many developing countries, cancer in Thailand is becoming a significant health problem. Cervix and breast cancer is the leading cause of death in Thai women. The only commercial DOX - encapsulated liposome available is Doxil. However, Doxil has a short half-life in microcirculation and is unstable in the blood stream. Hence there is a need to find a more controlled and stable DOX carrier system.
The researchers reported their work in a paper published by the Journal of Nanomaterials.
####
For more information, please click here
Contacts:
Ramjitti Indaraprasirt
Manager
Public Relations Section
NANOTEC
02-564-7100 ext: 6617
Copyright © NANOTEC
If you have a comment, please
Contact us.
Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Bookmark:
News and information
JPK reports on single molecule research at IISER Pune in India using AFM and CellHesion techniques May 21st, 2013
Imec and GLOBALFOUNDRIES collaborate to advance high-density memory technology: STT-MRAM offers enhanced performance and scalability for embedded and standalone applications May 21st, 2013
International survey supports need for built-in water protection on smartphones and tablets May 21st, 2013
Rice unveils method for tailoring optical processors: Arranging nanoparticles in geometric patterns allows for control of light with light May 21st, 2013
Nanomedicine
How Gold Nanoparticles Can Help Fight Ovarian Cancer May 21st, 2013
MU Researchers Develop Radioactive Nanoparticles that Target Cancer Cells: This is an early step toward developing therapies for metastasized cancers, MU scientist says May 21st, 2013
Nanoparticle Delivers Large Protein Complex to Cancer Cell Nucleus May 20th, 2013
Elsevier Business Intelligence (EBI) to Host 'IN3 Medical Device 360 Boston,' June 24-26, 2013 May 20th, 2013
Announcements
JPK reports on single molecule research at IISER Pune in India using AFM and CellHesion techniques May 21st, 2013
Imec and GLOBALFOUNDRIES collaborate to advance high-density memory technology: STT-MRAM offers enhanced performance and scalability for embedded and standalone applications May 21st, 2013
International survey supports need for built-in water protection on smartphones and tablets May 21st, 2013
Rice unveils method for tailoring optical processors: Arranging nanoparticles in geometric patterns allows for control of light with light May 21st, 2013