Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Simulated digestion: nanomaterials improve drug absorption

Functional lipid-based microparticles can be used to mimic the pharmaceutical food effect and enhance drug absorption by controlling the enzymatic digestion of lipid colloids.
Functional lipid-based microparticles can be used to mimic the pharmaceutical food effect and enhance drug absorption by controlling the enzymatic digestion of lipid colloids.

Abstract:
Some medicines have to be taken either before, after, or during a meal because food ingredients can affect their absorption or bioavailability. Australian researchers have now encapsulated drugs in a matrix of silicon dioxide and lipids to simulate the administration of pharmaceuticals with food. As the researchers report in the journal Angewandte Chemie, drug absorption is increased through control of the enzymatic digestion of the lipid droplets.

Simulated digestion: nanomaterials improve drug absorption

Germany | Posted on May 17th, 2012

For example, the body only absorbs fat-soluble vitamins A and D in the presence of some fat. Also, the bioavailability of many poorly water-soluble drugs increases when they are taken with high-fat meals. There are many techniques for the lipid-based delivery of pharmaceuticals, including emulsions, micelles and "packaging" in liposomes. These methods prevent the active ingredients from precipitating out and improve transportation to the absorption sites in the gastrointestinal tract. However, in order for the drug to become active in the body, it must be released from its lipid shell. The enzymatic decomposition of the lipid coating plays an important role in this process, but it has proven to be difficult to control. In addition, it is difficult to calculate the extent to which such lipid "packaging" really increases the bioavailability of a drug.

Clive Prestidge and a team at the University of South Australia and Monash University have now developed a controllable packaging type. Their material consists of a nanostructured network of silicon dioxide nanoparticles that contains nanoscopic lipid droplets containing the drug. This system is produced by generating a fine emulsion of the drug-containing oil droplets in an aqueous phase. The silicon dioxide particles collect around the droplets at the phase boundary. Spray-drying results in solid microparticles of entrapped lipid droplets.

The team has demonstrated that the lipid in these microparticles is enzymatically digested much more rapidly than pure lipid drops. This is because the nanostructured silicon dioxide network holds the enzymes close to their substrate. The size of the silicon dioxide particles used and the porosity of the resulting matrix determine how fast the enzymatic decomposition of the lipids occurs.

Animal trials with Celecoxib, a drug used to treat arthritis, showed a higher drug content in plasma when the pharmaceutical was orally administered in this new form rather than in its pure state or as drug-containing lipid drops. In contrast to Celecoxib-containing lipid drops, the release rate did not vary from batch to batch or after a longer storage period.

The new nanomaterial imitates the food effect in a predictable fashion and allows for better control of drug release, it could minimise the food effect on drug absorption and enhance more predictable therapeutic responses.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Link to the original paper on Wiley Online Library

Related News Press

News and information

NanoSummit in Luxembourg: single wall carbon nanotubes have entered our lives as we approach a nanoaugmented future November 23rd, 2017

JPK reports on the exciting research in the School of Medicine at Sungkyunkwan University (SKKU), Suwon, South Korea using the NanoWizardŽ ULTRA Speed AFM to understand the binding of transcription factor Sox2 with super enhancers November 23rd, 2017

Precision NanoSystems to host nanomedicines roundtable November 23rd, 2017

Fine felted nanotubes : Research team of Kiel University develops new composite material made of carbon nanotubes November 22nd, 2017

Nanomedicine

JPK reports on the exciting research in the School of Medicine at Sungkyunkwan University (SKKU), Suwon, South Korea using the NanoWizardŽ ULTRA Speed AFM to understand the binding of transcription factor Sox2 with super enhancers November 23rd, 2017

Precision NanoSystems to host nanomedicines roundtable November 23rd, 2017

Fine felted nanotubes : Research team of Kiel University develops new composite material made of carbon nanotubes November 22nd, 2017

Nanoparticles could allow for faster, better medicine: Exposure of nanoparticles in the body allows for more effective delivery November 20th, 2017

Discoveries

Fine felted nanotubes : Research team of Kiel University develops new composite material made of carbon nanotubes November 22nd, 2017

Quantum optics allows us to abandon expensive lasers in spectroscopy: Lomonosov Moscow State University scientists have invented a new method of spectroscopy November 21st, 2017

Nano-watch has steady hands November 21st, 2017

Nanoparticles could allow for faster, better medicine: Exposure of nanoparticles in the body allows for more effective delivery November 20th, 2017

Announcements

NanoSummit in Luxembourg: single wall carbon nanotubes have entered our lives as we approach a nanoaugmented future November 23rd, 2017

JPK reports on the exciting research in the School of Medicine at Sungkyunkwan University (SKKU), Suwon, South Korea using the NanoWizardŽ ULTRA Speed AFM to understand the binding of transcription factor Sox2 with super enhancers November 23rd, 2017

Precision NanoSystems to host nanomedicines roundtable November 23rd, 2017

Fine felted nanotubes : Research team of Kiel University develops new composite material made of carbon nanotubes November 22nd, 2017

Food/Agriculture/Supplements

Report highlights opportunities and risks associated with synthetic biology and bioengineering November 22nd, 2017

A new way to mix oil and water: Condensation-based method developed at MIT could create stable nanoscale emulsions November 8th, 2017

Quorum reports on how cryo prep techniques for SEM are being applied in the Laboratory of Food Technology & Engineering at the University of Ghent, Belgium November 7th, 2017

Research shows how DNA molecules cross nanopores: Study could inform biosensors, manufacturing, and more September 5th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project