Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Designing Nanomaterials for Drug Delivery

Confocal laser scanning microscopy images of the protein-based nanoparticles incubated with breast cancer cells.
Confocal laser scanning microscopy images of the protein-based nanoparticles incubated with breast cancer cells.

Abstract:
Natural biological entities have been highly successful in fabricating nanoscale structures and functional systems, leading to scientific exploration of biologically inspired strategies for materials design. In particular, protein-based materials can combine natural properties, structural elements, and biologically reactive sites to obtain self-assembled nanoarchitectures with applications including tissue engineering, nanomaterials synthesis, and drug delivery. However, the functionality of these materials can be limited by the locations or absence of specific chemical conjugation sites.

Designing Nanomaterials for Drug Delivery

Germany | Posted on April 26th, 2012

To circumvent this limitation, an investigation by Ren et al., at the University of California, Irvine, implemented a novel, non-covalent strategy to attach guest molecules into a protein-based nanocapsule. Their biomimetic inspiration was multi-drug efflux transporters, which bind a remarkably broad range of structurally-divergent molecules using phenylalanine, a hydrophobic amino acid. Through protein engineering, the team introduced targeted non-native phenylalanines into the hollow cavity of a caged protein scaffold.

The transformed nanoparticles enabled the antitumor drug doxorubicin to bind to the cavity at high loading capacities. These drug-protein complexes could subsequently be applied to induce death in breast cancer cells. Significantly, this work demonstrates a generalized strategy to engineer binding domains within protein-based materials that does not rely on conventional chemical coupling, thus extending the potential functionality of such materials.

Source: University of California, Irvine

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Deep Space Industries and SFL selected to provide satellites for HawkEye 360’s Pathfinder mission: The privately-funded space-based global wireless signal monitoring system will be developed by Deep Space Industries and UTIAS Space Flight Laboratory May 26th, 2016

Nanomedicine

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Nanoscale Trojan horses treat inflammation May 24th, 2016

Discoveries

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Finding a new formula for concrete: Researchers look to bones and shells as blueprints for stronger, more durable concrete May 26th, 2016

Announcements

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Deep Space Industries and SFL selected to provide satellites for HawkEye 360’s Pathfinder mission: The privately-funded space-based global wireless signal monitoring system will be developed by Deep Space Industries and UTIAS Space Flight Laboratory May 26th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic