Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Designing Nanomaterials for Drug Delivery

Confocal laser scanning microscopy images of the protein-based nanoparticles incubated with breast cancer cells.
Confocal laser scanning microscopy images of the protein-based nanoparticles incubated with breast cancer cells.

Abstract:
Natural biological entities have been highly successful in fabricating nanoscale structures and functional systems, leading to scientific exploration of biologically inspired strategies for materials design. In particular, protein-based materials can combine natural properties, structural elements, and biologically reactive sites to obtain self-assembled nanoarchitectures with applications including tissue engineering, nanomaterials synthesis, and drug delivery. However, the functionality of these materials can be limited by the locations or absence of specific chemical conjugation sites.

Designing Nanomaterials for Drug Delivery

Germany | Posted on April 26th, 2012

To circumvent this limitation, an investigation by Ren et al., at the University of California, Irvine, implemented a novel, non-covalent strategy to attach guest molecules into a protein-based nanocapsule. Their biomimetic inspiration was multi-drug efflux transporters, which bind a remarkably broad range of structurally-divergent molecules using phenylalanine, a hydrophobic amino acid. Through protein engineering, the team introduced targeted non-native phenylalanines into the hollow cavity of a caged protein scaffold.

The transformed nanoparticles enabled the antitumor drug doxorubicin to bind to the cavity at high loading capacities. These drug-protein complexes could subsequently be applied to induce death in breast cancer cells. Significantly, this work demonstrates a generalized strategy to engineer binding domains within protein-based materials that does not rely on conventional chemical coupling, thus extending the potential functionality of such materials.

Source: University of California, Irvine

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nanosensors could help determine tumors’ ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Innovation in Nanotechnology is Focus of Symposium: Annual event brings international experts to Northwestern Oct. 6 September 29th, 2016

Cambrios at CEATEC - Japan 2016 September 29th, 2016

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

Nanomedicine

Nanosensors could help determine tumors’ ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

Discoveries

Nanosensors could help determine tumors’ ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

UNAM develops successful nano edible coating which increases life food September 27th, 2016

Announcements

Nanosensors could help determine tumors’ ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Innovation in Nanotechnology is Focus of Symposium: Annual event brings international experts to Northwestern Oct. 6 September 29th, 2016

Cambrios at CEATEC - Japan 2016 September 29th, 2016

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic