Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Designing Nanomaterials for Drug Delivery

Confocal laser scanning microscopy images of the protein-based nanoparticles incubated with breast cancer cells.
Confocal laser scanning microscopy images of the protein-based nanoparticles incubated with breast cancer cells.

Abstract:
Natural biological entities have been highly successful in fabricating nanoscale structures and functional systems, leading to scientific exploration of biologically inspired strategies for materials design. In particular, protein-based materials can combine natural properties, structural elements, and biologically reactive sites to obtain self-assembled nanoarchitectures with applications including tissue engineering, nanomaterials synthesis, and drug delivery. However, the functionality of these materials can be limited by the locations or absence of specific chemical conjugation sites.

Designing Nanomaterials for Drug Delivery

Germany | Posted on April 26th, 2012

To circumvent this limitation, an investigation by Ren et al., at the University of California, Irvine, implemented a novel, non-covalent strategy to attach guest molecules into a protein-based nanocapsule. Their biomimetic inspiration was multi-drug efflux transporters, which bind a remarkably broad range of structurally-divergent molecules using phenylalanine, a hydrophobic amino acid. Through protein engineering, the team introduced targeted non-native phenylalanines into the hollow cavity of a caged protein scaffold.

The transformed nanoparticles enabled the antitumor drug doxorubicin to bind to the cavity at high loading capacities. These drug-protein complexes could subsequently be applied to induce death in breast cancer cells. Significantly, this work demonstrates a generalized strategy to engineer binding domains within protein-based materials that does not rely on conventional chemical coupling, thus extending the potential functionality of such materials.

Source: University of California, Irvine

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Cryo-electron microscopy achieves unprecedented resolution using new computational methods March 25th, 2017

Argon is not the 'dope' for metallic hydrogen March 24th, 2017

Promising results obtained with a new electrocatalyst that reduces the need for platinum: Researchers from Aalto University have succeeded in manufacturing electrocatalysts used for storing electric energy with one-hundredth of the amount of platinum that is usually needed March 24th, 2017

Artificial photosynthesis steps into the light: Rice University lab turns transition metals into practical catalyst for solar, other applications March 23rd, 2017

Nanomedicine

Cryo-electron microscopy achieves unprecedented resolution using new computational methods March 25th, 2017

Nanobiotix: The Independent Data Monitoring Committee Recommends the Continuation of the Ongoing Phase II/III Trial of NBTXR3 in Soft Tissue Sarcoma March 23rd, 2017

Nanoparticle paves the way for new triple negative breast cancer drug March 20th, 2017

Block copolymer micellization as a protection strategy for DNA origami March 17th, 2017

Discoveries

Cryo-electron microscopy achieves unprecedented resolution using new computational methods March 25th, 2017

Argon is not the 'dope' for metallic hydrogen March 24th, 2017

Promising results obtained with a new electrocatalyst that reduces the need for platinum: Researchers from Aalto University have succeeded in manufacturing electrocatalysts used for storing electric energy with one-hundredth of the amount of platinum that is usually needed March 24th, 2017

Artificial photosynthesis steps into the light: Rice University lab turns transition metals into practical catalyst for solar, other applications March 23rd, 2017

Announcements

Cryo-electron microscopy achieves unprecedented resolution using new computational methods March 25th, 2017

Argon is not the 'dope' for metallic hydrogen March 24th, 2017

Promising results obtained with a new electrocatalyst that reduces the need for platinum: Researchers from Aalto University have succeeded in manufacturing electrocatalysts used for storing electric energy with one-hundredth of the amount of platinum that is usually needed March 24th, 2017

Artificial photosynthesis steps into the light: Rice University lab turns transition metals into practical catalyst for solar, other applications March 23rd, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project