Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Carbon Nanotubes Kill Breast Cancer Stem Cells

Abstract:
Breast cancer stem cells, the slow-growing, hard-to-kill malignant cells that are thought to be responsible for the growth and spread of breast cancer, have proven remarkably resistant to traditional chemotherapy and radiation therapy. Now, researchers at Wake Forest Baptist Medical Center have shown that multi-walled carbon nanotubes (MWCNTs) injected into breast tumors and irradiated with a quick, 30-second laser beam, are effective at killing breast cancer stem cells.

Carbon Nanotubes Kill Breast Cancer Stem Cells

Bethesda, MD | Posted on April 5th, 2012

Suzy Torti led the research team that conducted this work. She and her colleagues published their finding in the journal Biomaterials. Earlier work by Dr. Torti's research team had demonstrated that MWCNTs irradiated with short laser pulses generate heat that can kill kidney tumors.

Using a mouse model of human breast cancer, the researchers injected tumors containing breast cancer stem cells with MWCNTs, which consist of concentric tubes of graphite. By themselves, nanotubes do not kill tumors, but if they are exposed to laser-generated, near-infrared radiation they start to vibrate and produce heat. This combination can produce a local region in the tumor that is hot enough to kill any tumor cell, not just those that are growing rapidly.

Using this method, the group was able to stop the growth of tumors that were largely composed of breast cancer stem cells. Breast cancer stem cells have high levels of the protein hsp90 which enables them to adapt to higher temperature fluctuations. The investigators showedthat rapid induction of high temperatures by the laser induces cell death by a process known as necrosis even when hsp90 is present. In fact, tumor-bearing mice treated with this therapy experienced complete tumor regression and long-term survival. These findings suggest that nanotube-mediated thermal treatment can eliminate both the differentiated cells that constitute the bulk of the tumor and the cancer stem cells that drive tumor growth and recurrence.

This work, which was supported in part by the National Cancer Institute, is detailed in a paper titled, "The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy." An abstract of this paper is available at the journal's website.

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - "The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy."

Related News Press

News and information

Physicists gain new insights into nanosystems with spherical confinement: Enormous potential for the targeted delivery of pharmaceutical agents and the creation of tailored nanoparticles July 27th, 2017

Strange electrons break the crystal symmetry of high-temperature superconductors: Brookhaven Lab scientists discover spontaneous voltage perpendicular to applied current that may help unravel the mystery of high-temperature superconductors July 27th, 2017

Getting closer to porous, light-responsive materials: A new flexible material changes its porous nature when exposed to light July 27th, 2017

First Capacitive Transducer with 13nm Gap July 27th, 2017

Govt.-Legislation/Regulation/Funding/Policy

Strange electrons break the crystal symmetry of high-temperature superconductors: Brookhaven Lab scientists discover spontaneous voltage perpendicular to applied current that may help unravel the mystery of high-temperature superconductors July 27th, 2017

Graduate Students from Across the Country Attend Hands-on NanoCamp: Prominent scientists Warren Oliver, Ph.D., and George Pharr, Ph.D., presented a weeklong NanoCamp for hand-picked graduate students across the United States July 26th, 2017

Ultrathin device harvests electricity from human motion July 23rd, 2017

Semiliquid chains pulled out of a sea of microparticles July 20th, 2017

Nanotubes/Buckyballs/Fullerenes/Nanorods

Regulation of two-dimensional nanomaterials: New driving force for lithium-ion batteries July 26th, 2017

Killing cancer in the heat of the moment: A new method efficiently transfers genes into cells, then activates them with light. This could lead to gene therapies for cancers July 9th, 2017

Tests show no nanotubes released during utilisation of nanoaugmented materials June 9th, 2017

Ag/ZnO-Nanorods Schottky diodes based UV-PDs are fabricated and tested May 26th, 2017

Nanomedicine

Physicists gain new insights into nanosystems with spherical confinement: Enormous potential for the targeted delivery of pharmaceutical agents and the creation of tailored nanoparticles July 27th, 2017

Shining rings: A new material emits white light when exposed to electricity: New synthetic approach could spark development of other dynamic materials July 24th, 2017

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Probiotics: Novel biosynthetic tool to develop metallic nanoparticles: This research article by Dr. Nida Akhtar et al has been published in Recent Patents on Drug Delivery & Formulation, Volume 11, Issue 1, 2017 July 20th, 2017

Discoveries

Physicists gain new insights into nanosystems with spherical confinement: Enormous potential for the targeted delivery of pharmaceutical agents and the creation of tailored nanoparticles July 27th, 2017

Strange electrons break the crystal symmetry of high-temperature superconductors: Brookhaven Lab scientists discover spontaneous voltage perpendicular to applied current that may help unravel the mystery of high-temperature superconductors July 27th, 2017

Getting closer to porous, light-responsive materials: A new flexible material changes its porous nature when exposed to light July 27th, 2017

First Capacitive Transducer with 13nm Gap July 27th, 2017

Announcements

Physicists gain new insights into nanosystems with spherical confinement: Enormous potential for the targeted delivery of pharmaceutical agents and the creation of tailored nanoparticles July 27th, 2017

Strange electrons break the crystal symmetry of high-temperature superconductors: Brookhaven Lab scientists discover spontaneous voltage perpendicular to applied current that may help unravel the mystery of high-temperature superconductors July 27th, 2017

Getting closer to porous, light-responsive materials: A new flexible material changes its porous nature when exposed to light July 27th, 2017

First Capacitive Transducer with 13nm Gap July 27th, 2017

Photonics/Optics/Lasers

Getting closer to porous, light-responsive materials: A new flexible material changes its porous nature when exposed to light July 27th, 2017

Scientists announce the quest for high-index materials: All-dielectric nanophotonics: The quest for better materials and fabrication techniques July 22nd, 2017

Nanoparticles could spur better LEDs, invisibility cloaks July 19th, 2017

'Upconverted' light has a bright future: Rice University professor developing plasmon-powered devices for medicine, security, solar cells July 17th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project