Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > PRINTed Nanoparticles Delivery Multiple Punches to Treat Prostate Cancer

Abstract:
Using technologies common to the semiconductor industry, a team of investigators at the University of North Carolina at Chapel Hill and Liquidia Technologies has created a polymer nanoparticle that can encapsulate large loads of therapeutic molecules that may have use in treating prostate cancer. The research, led by Joseph DeSimone, co-principal investigator of the Carolina Center for Cancer Nanotechnology, was published in the journal Nano Letters.

PRINTed Nanoparticles Delivery Multiple Punches to Treat Prostate Cancer

Bethesda, MD | Posted on January 19th, 2012

Dr. DeSimone and his colleagues developed their nanoparticles to deliver small interfering RNA (siRNA) molecules to tumors. siRNAs block or greatly reduce a cell's production of specific proteins by binding to the messenger RNA (mRNA) molecules that translate information from DNA into proteins. Because of their specificity for specific proteins, siRNAs are thought to hold promise as anticancer agents, but only if techniques can be developed to deliver large quantities of siRNAs to tumor cells.

With an eye on commercialization, the Carolina team created an siRNA delivery vehicle using the PRINT process, which was invented in Dr. DeSimone's laboratory and is now being developed for biomedical applications by Liquidia Technologies. PRINT uses soft lithography to mass produce polymeric nanoparticles under mild conditions suitable for use with biologically compatible materials. In this project, the team created nanoparticles consisting of a polymer core that safely encapsulates siRNA molecules and a lipid shell that promotes cell uptake.

Initial tests with cells engineered to produce a fluorescent protein and a nanoparticle containing an siRNA agent that would block production of this protein, the investigators showed that these particles were readily taken up by the cells. Once inside the cells, the polymeric nanoparticles released their siRNA payload, blocking production of the fluorescent protein.

Next, the investigators created a nanoparticle containing an siRNA designed to interfere with the production of a protein known as KIF11, which plays a role in prostate tumor growth. They then dosed three different prostate cancer cell lines with this formulation and found that all three cell lines experienced a dramatic drop in KIF11 levels, which in turn triggered cell death in all three cell lines. The researchers note that they are now performing animal studies with PRINTed nanoparticles loaded with siRNAs targeted to key tumor proteins.

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - "Delivery of multiple siRNAs using lipid-coated PLGA nanoparticles for treatment of prostate cancer."

Related News Press

News and information

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

Leti & EFI Aim to Dramatically Improve Reliability & Speed of Low-Cost Electronic Devices for Autos: Project Will Extend Model Predictive Control Technique to Microcontrollers, Digital Signal Processors and Other Devices that Lack Powerful Computation Capabilities September 18th, 2018

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

Tiny camera lens may help link quantum computers to network September 14th, 2018

Govt.-Legislation/Regulation/Funding/Policy

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Could a demon help to create a quantum computer? Physicists implement a version of Maxwell's famous thought experiment for reducing entropy September 5th, 2018

Ultracold atoms used to verify 1963 prediction about 1D electrons: Rice University, University of Geneva study focuses on theory that's increasingly relevant to chipmakers September 5th, 2018

Nanomedicine

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

A Comprehensive Guide: The Future of Nanotechnology September 13th, 2018

Carbon nanodots do an ultrafine job with in vitro lung tissue: New experiments highlight the role of charge and size when it comes to carbon nanodots that mimic the effect of nanoscale pollution particles on the human lung. September 12th, 2018

Rice U. lab probes molecular limit of plasmonics: Optical effect detailed in organic molecules with fewer than 50 atoms September 5th, 2018

Discoveries

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

Tiny camera lens may help link quantum computers to network September 14th, 2018

New devices based on rust could reduce excess heat in computers: Physicists explore long-distance information transmission in antiferromagnetic iron oxide September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Announcements

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

Leti & EFI Aim to Dramatically Improve Reliability & Speed of Low-Cost Electronic Devices for Autos: Project Will Extend Model Predictive Control Technique to Microcontrollers, Digital Signal Processors and Other Devices that Lack Powerful Computation Capabilities September 18th, 2018

New devices based on rust could reduce excess heat in computers: Physicists explore long-distance information transmission in antiferromagnetic iron oxide September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Printing/Lithography/Inkjet/Inks/Bio-printing

Laser sintering optimized for printed electronics: New study sheds (laser) light on the best means of laying down thin-film circuitry September 13th, 2018

Virginia Tech researchers develop novel process to 3D print one of the strongest materials on Earth August 23rd, 2018

Color effects from transparent 3D printed nanostructures: New design tool automatically creates nanostructure 3D print templates for user-given colors Scientists present work at prestigious SIGGRAPH conference August 18th, 2018

CTI Materials drives nano commercialization with it's patented surfactant free nanoparticle dispersions August 15th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project