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Iranian researchers at Isfahan University of Technology in association with researchers from Tehran University of Medical Sciences produced an optimum nanocomposite scaffold which can be used in bone tissue engineering.
"We made effort to produce biodegradable and bioactive nanocomposite scaffold by using polycaprolactone / fluoro-hydroxyapatite nanoparticles for bone tissue engineering purposes. We wanted the nanocomposite scaffold to have better behavior and solubility rate in comparison with polycaprolactone / hydroxyl apatite scaffolds," Narges Johari, one of the researchers, told INIC.
"To this end, we firstly produced a porous nanocomposite scaffold containing four various weight percentages of fluoro-hydroxyapatite nanoparticles," she continued, saying, "Then, we characterized the microstructure, morphology, porosity, and mechanical properties of the nanocomposite, and we studied its bioactivity in the simulated body fluid (SBF), its degradability in phosphate buffered saline (PBS) solution, and its biocompatibility and cellular non-toxicity. Fluoro-hydroxyapatite nanoparticles used in the production of nanocomposite scaffolds contained 25, 50, 75, and 100% of fluor ion replacement in their structure."
The researcher of the project also elaborated on the obtained results, and said, "The results showed that as the replacement of fluor ion increases in fluoro-hydroxyapatite that played a strengthening role in the structure of nanocomposite scaffold of polycaprolactone / fluoro-hydroxyapatite, pressure strength of the scaffold decreases but its biodegradability increases."
"Generally speaking, we concluded that the optimum nanocomposite scaffold for bone tissue engineering is the one with 40 weight percent of fluoro-hydroxyapatite nanoparticles with porosity of 75%, while 25% of fluor ion replacement existed in its structure."
The researchers of the project seek to present their product for mass-production when investigations about its effect inside the body are completed.
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