Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Novel Gold-Nanoparticle-Based Assay for Understanding Alzheimer’s Disease

Abstract:
Acetylcholinesterase (AChE) is an enzyme that can catalytically break down acetylcholine at cholinergic synapses, resulting in the termination of synaptic transmission. It had been shown that the level of AChE in the cerebrospinal fluid of individuals suffering from Alzheimer's disease is significantly reduced. Therefore, a low level of AChE may indicate a risk or a preclinical stage of Alzheimer's disease. This information could be useful for early prevention and treatment of the disease. However, to date there is no accurate method for identifying Alzheimer's disease in an early or asymptomatic stage of the disease.

Novel Gold-Nanoparticle-Based Assay for Understanding Alzheimer’s Disease

Germany | Posted on December 13th, 2011

The clinical application of existing gold nanoparticle (AuNP)-based colorimetric assays is hampered by their moderate sensitivity and selectivity. Now, however, Xingyu Jiang and co-workers (National Center for Nanoscience and Technology, Beijing) have developed a novel AuNP-based assay highly sensitive to acetylcholinesterase (AChE). The fluorescence of Rhodamine B detached from Au surfaces is measured and simultaneously the color change of AuNPs solutions is known.

This new assay provides a detection limit (0.1 mU/mL) much lower than that of all existing probes for AChE. Such a high sensitivity allows the measurement of AChE in the cerebrospinal fluid even after being diluted more than a thousand times. In this manner, false positive results for other components like biothiols in real samples can be ruled out and relevant clinical tests are rendered possible. The study shows that the level of AChE in model mice that suffer from Alzheimer's disease (AD) is lower than that in healthy mice. The assay also allows the progression of the disease and the effect of drug treatments to be studied by monitoring the AChE level in the model mice treated with different drug dosages.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Dingbin Liu et al., Adv. Healthcare Mat. ; DOI: 10.1002/adhm.201100002

Related News Press

News and information

Animal study shows flexible, dissolvable silicon device promising for brain monitoring: Other applications include post-operative observation for vascular, cardiac, and orthopaedic procedures, finds Penn study May 5th, 2016

Speedy ion conduction in solid electrolytes clears road for advanced energy devices May 5th, 2016

Engineers create a better way to boil water -- with industrial, electronics applications May 5th, 2016

Clues on the path to a new lithium battery technology: Charging produces highly reactive singlet oxygen in lithium air batteries May 5th, 2016

Nanomedicine

Animal study shows flexible, dissolvable silicon device promising for brain monitoring: Other applications include post-operative observation for vascular, cardiac, and orthopaedic procedures, finds Penn study May 5th, 2016

Unique nano-capsules promise the targeted drug delivery: Russian scientists created unique nano-capsules for the targeted drug delivery May 5th, 2016

The intermediates in a chemical reaction photographed 'red-handed' Researchers at the UPV/EHU-University of the Basque Country have for the first time succeeded in imaging all the steps in a complex organic reaction and have resolved the mechanisms that explain it May 4th, 2016

Nuclear pores captured on film: Using an ultra fast-scanning atomic force microscope, researchers from the University of Basel have filmed 'living' nuclear pore complexes at work for the first time May 3rd, 2016

Discoveries

Animal study shows flexible, dissolvable silicon device promising for brain monitoring: Other applications include post-operative observation for vascular, cardiac, and orthopaedic procedures, finds Penn study May 5th, 2016

Speedy ion conduction in solid electrolytes clears road for advanced energy devices May 5th, 2016

Engineers create a better way to boil water -- with industrial, electronics applications May 5th, 2016

Unique nano-capsules promise the targeted drug delivery: Russian scientists created unique nano-capsules for the targeted drug delivery May 5th, 2016

Announcements

Speedy ion conduction in solid electrolytes clears road for advanced energy devices May 5th, 2016

Engineers create a better way to boil water -- with industrial, electronics applications May 5th, 2016

Clues on the path to a new lithium battery technology: Charging produces highly reactive singlet oxygen in lithium air batteries May 5th, 2016

Unique nano-capsules promise the targeted drug delivery: Russian scientists created unique nano-capsules for the targeted drug delivery May 5th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic