Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Defying Expectation - Cellular Uptake of Nanoparticles

Abstract:
Where previously materials with useful properties have seen widespread application prior to the discovery of their potentially undesirable behaviours - asbestos comes to mind - the introduction of new materials to our living and working environments is now preceded by ever more complex and rigourous testing.

Defying Expectation - Cellular Uptake of Nanoparticles

Germany | Posted on November 24th, 2011

Nanomaterials in particular have become a part of the collective consciousness, and not just because of the myriad cautionary science fiction based on this size regime: Nanoparticles of all shapes and compositions are popping up with increasing regularity in research fields from electronics to medicine but, because of their often surprisingly different behaviours as compared to their bulk counterparts, it is even more important to be able to predict and control their interactions before giving them the green light.

As regards the human body's ability to deal with foreign materials, studies of the uptake and retention of nanoparticles in different organs are becoming more frequent in an effort to prove or improve the safety of these particles in environments where we are likely to come into direct contact with them.

Medicine is an obvious example, where nanoparticles have shown great promise as agents for targeted drug or gene delivery, chemotherapy, and non-invasive imaging. However, in such cases it is highly desirable to be able to engineer particles able to evade the body's clearance mechanisms, at least for long enough to deliver a drug payload to an appropriate site in the body, for example.

With that in mind, a group working in Dublin has investigated the quantitative effect of particle size on the uptake efficiency and localisation of carboxylated polystyrene nanoparticles across cell lines from different parts of the human body, representative of the main avenues of exposure to such particles, as well as the variation in uptake kinetics for the different cell types. Their confocal microscopy and flow cytometry results suggest that nanoparticle uptake defies the expected size limits for uptake processes: a result which has important implications for the future safety assessments of these nanomaterials.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Tiago dos Santos, Small, 2011 ; DOI: 10.1002/smll.201101076

Related News Press

News and information

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Discoveries

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Mechanism behind nature's sparkles revealed October 22nd, 2014

Researchers patent a nanofluid that improves heat conductivity October 22nd, 2014

Announcements

NanoTechnology for Defense (NT4D) October 22nd, 2014

Mechanism behind nature's sparkles revealed October 22nd, 2014

TARA Biosystems and Harris & Harris Group Form Company to Improve Safety and Efficacy of New Therapies October 22nd, 2014

Researchers patent a nanofluid that improves heat conductivity October 22nd, 2014

Environment

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Physicists build reversible laser tractor beam October 20th, 2014

Plastic nanoparticles also harm freshwater organisms October 18th, 2014

New Nanocomposites Help Elimination of Toxic Dyes October 15th, 2014

Safety-Nanoparticles/Risk management

Plastic nanoparticles also harm freshwater organisms October 18th, 2014

Human health, wealth require expanded marine science, experts say: In Rome, European experts publish a 'common vision' of priorities for marine research and action through 2020 October 9th, 2014

Coating Nanotubes with Aluminum Oxide Lowers Risk of Lung Injury October 6th, 2014

PEN Inc. Chairman Scott Rickert Announces Company Vision, Product Priorities and Management Team: Webcast Highlights the Launch of PEN October 3rd, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE