Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Defying Expectation - Cellular Uptake of Nanoparticles

Abstract:
Where previously materials with useful properties have seen widespread application prior to the discovery of their potentially undesirable behaviours - asbestos comes to mind - the introduction of new materials to our living and working environments is now preceded by ever more complex and rigourous testing.

Defying Expectation - Cellular Uptake of Nanoparticles

Germany | Posted on November 24th, 2011

Nanomaterials in particular have become a part of the collective consciousness, and not just because of the myriad cautionary science fiction based on this size regime: Nanoparticles of all shapes and compositions are popping up with increasing regularity in research fields from electronics to medicine but, because of their often surprisingly different behaviours as compared to their bulk counterparts, it is even more important to be able to predict and control their interactions before giving them the green light.

As regards the human body's ability to deal with foreign materials, studies of the uptake and retention of nanoparticles in different organs are becoming more frequent in an effort to prove or improve the safety of these particles in environments where we are likely to come into direct contact with them.

Medicine is an obvious example, where nanoparticles have shown great promise as agents for targeted drug or gene delivery, chemotherapy, and non-invasive imaging. However, in such cases it is highly desirable to be able to engineer particles able to evade the body's clearance mechanisms, at least for long enough to deliver a drug payload to an appropriate site in the body, for example.

With that in mind, a group working in Dublin has investigated the quantitative effect of particle size on the uptake efficiency and localisation of carboxylated polystyrene nanoparticles across cell lines from different parts of the human body, representative of the main avenues of exposure to such particles, as well as the variation in uptake kinetics for the different cell types. Their confocal microscopy and flow cytometry results suggest that nanoparticle uptake defies the expected size limits for uptake processes: a result which has important implications for the future safety assessments of these nanomaterials.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Tiago dos Santos, Small, 2011 ; DOI: 10.1002/smll.201101076

Related News Press

News and information

Organometallics welcomes new editor-in-chief: Paul Chirik, Ph.D. July 22nd, 2014

The Hiden EQP Plasma Diagnostic with on-board MCA July 22nd, 2014

Iran to Hold 3rd Int'l Forum on Nanotechnology Economy July 22nd, 2014

Nanometrics Announces Upcoming Investor Events July 22nd, 2014

Discoveries

Researchers create vaccine for dust-mite allergies Main Page Content: Vaccine reduced lung inflammation to allergens in lab and animal tests July 22nd, 2014

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

Penn Study: Understanding Graphene’s Electrical Properties on an Atomic Level July 22nd, 2014

NUS scientists use low cost technique to improve properties and functions of nanomaterials: By 'drawing' micropatterns on nanomaterials using a focused laser beam, scientists could modify properties of nanomaterials for effective applications in photonic and optoelectric applicat July 22nd, 2014

Announcements

Nanometrics Announces Upcoming Investor Events July 22nd, 2014

Bruker Awarded Fourth PeakForce Tapping Patent: AFM Mode Uniquely Combines Highest Resolution Imaging and Material Property Mapping July 22nd, 2014

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

Penn Study: Understanding Graphene’s Electrical Properties on an Atomic Level July 22nd, 2014

Environment

Researchers Use Various Zinc Oxide Nanostructures to Boost Efficiency of Water Purification Process July 13th, 2014

Using Sand to Improve Battery Performance: Researchers develop low cost, environmentally friendly way to produce sand-based lithium ion batteries that outperform standard by three times July 8th, 2014

Development of an interactive tool for the implementation of environmental legislation for nanoparticles manufacturers July 4th, 2014

Up in Flames: Evidence Confirms Combustion Theory: Berkeley Lab and University of Hawaii research outlines the story of soot, with implications for cleaner-burning fuels July 1st, 2014

Safety-Nanoparticles/Risk management

Development of an interactive tool for the implementation of environmental legislation for nanoparticles manufacturers July 4th, 2014

FDA issues guidance on use of nanotechnology in foods July 1st, 2014

Nano-coatings release almost no nano-particles: Silver in the washing machine June 30th, 2014

NNI releases progress review on environmental, health, & safety research June 26th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE