Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Defying Expectation - Cellular Uptake of Nanoparticles

Abstract:
Where previously materials with useful properties have seen widespread application prior to the discovery of their potentially undesirable behaviours - asbestos comes to mind - the introduction of new materials to our living and working environments is now preceded by ever more complex and rigourous testing.

Defying Expectation - Cellular Uptake of Nanoparticles

Germany | Posted on November 24th, 2011

Nanomaterials in particular have become a part of the collective consciousness, and not just because of the myriad cautionary science fiction based on this size regime: Nanoparticles of all shapes and compositions are popping up with increasing regularity in research fields from electronics to medicine but, because of their often surprisingly different behaviours as compared to their bulk counterparts, it is even more important to be able to predict and control their interactions before giving them the green light.

As regards the human body's ability to deal with foreign materials, studies of the uptake and retention of nanoparticles in different organs are becoming more frequent in an effort to prove or improve the safety of these particles in environments where we are likely to come into direct contact with them.

Medicine is an obvious example, where nanoparticles have shown great promise as agents for targeted drug or gene delivery, chemotherapy, and non-invasive imaging. However, in such cases it is highly desirable to be able to engineer particles able to evade the body's clearance mechanisms, at least for long enough to deliver a drug payload to an appropriate site in the body, for example.

With that in mind, a group working in Dublin has investigated the quantitative effect of particle size on the uptake efficiency and localisation of carboxylated polystyrene nanoparticles across cell lines from different parts of the human body, representative of the main avenues of exposure to such particles, as well as the variation in uptake kinetics for the different cell types. Their confocal microscopy and flow cytometry results suggest that nanoparticle uptake defies the expected size limits for uptake processes: a result which has important implications for the future safety assessments of these nanomaterials.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Tiago dos Santos, Small, 2011 ; DOI: 10.1002/smll.201101076

Related News Press

News and information

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Oxford Instruments Asylum Research Introduces the MFP-3D InfinityTM AFM Featuring Powerful New Capabilities and Stunning High Performance April 18th, 2014

Conductive Inks: booming to $2.8 billion by 2024 April 17th, 2014

Discoveries

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Thinnest feasible membrane produced April 17th, 2014

More effective kidney stone treatment, from the macroscopic to the nanoscale April 17th, 2014

Announcements

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Oxford Instruments Asylum Research Introduces the MFP-3D InfinityTM AFM Featuring Powerful New Capabilities and Stunning High Performance April 18th, 2014

Transparent Conductive Films and Sensors Are Hot Segments in Printed Electronics: Start-ups in these fields show above-average momentum, while companies working on emissive displays such as OLED are fading, Lux Research says April 17th, 2014

Environment

Trees go high-tech: process turns cellulose into energy storage devices April 7th, 2014

Fabricating Nanostructures with Silk Could Make Clean Rooms Green Rooms March 31st, 2014

University of Waterloo Engineering to Showcase Student Design March 14th, 2014

Iran Applying Nanotechnology in Growing Number of Industries March 10th, 2014

Safety-Nanoparticles/Risk management

INSCX™ exchange to present Exchange trade reporting mechanism for engineered nanomaterials (NMs) to UK regulation agencies, insurers and upstream/downstream users April 17th, 2014

ECHA Planning Workshop on Regulatory Challenges in the Risk Assessment of Nanomaterials April 16th, 2014

Effects of Carbon Nanotubes Studied on Pregnant Mothers April 12th, 2014

Local girl does good March 22nd, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE