Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > DNA origami: Researchers fabricate DNA strands on a reusable chip, fold them into novel nanostructures

Abstract:
In the emerging field of synthetic biology, engineers use biological building blocks, such as snippets of DNA, to construct novel technologies. One of the key challenges in the field is finding a way to quickly and economically synthesize the desired DNA strands. Now scientists from Duke University have fabricated a reusable DNA chip that may help address this problem by acting as a template from which multiple batches of DNA building blocks can be photocopied. The researchers have used the device to create strands of DNA which they then folded into unique nanoscale structures. They will present their findings at the AVS Symposium, held Oct. 30 - Nov. 4, in Nashville, Tennessee.

DNA origami: Researchers fabricate DNA strands on a reusable chip, fold them into novel nanostructures

College Park, MD | Posted on November 1st, 2011

Many different methods of DNA synthesis have been developed, but each method has its drawbacks. Bulk DNA synthesis, which makes use of separate columns to house the reactions, can produce large amounts of material, but is costly and limited in the number of different DNA sequences it can create. The Duke researchers, by contrast, used an inkjet printer head to deposit small droplets of chemicals on top of a plastic chip, gradually constructing DNA strands of mixed length and composition on the surface. The team then used a biological photocopying process to harvest the DNA from the chip. To the researchers' surprise, they found they could reuse the chip to harvest multiple batches of DNA. "We found that we had an "immortal" DNA chip in our hands," says Ishtiaq Saaem, a biomedical engineering researcher at Duke and member of the team. "Essentially, we were able to do the biological copying process to release material off the chip tens of times. The process seems to work even using a chip that we made, used, stored in -20C for a while, and brought out and used again."

After releasing the DNA from the chip, the team "cooked" it together with a piece of long viral DNA. "In the cooking process, the viral DNA is stapled into a desired shape by the smaller chip-derived DNA," explains Saaem. One of the team's first examples of DNA origami was a rectangle shape with a triangle attached on one side, which the researchers dubbed a "nano-house." The structure could be used to spatially orient organic and inorganic materials, serve as a scaffold for drug delivery, or act as a nanoscale ruler, Saaem says.

Going forward, the team intends to produce larger DNA structures, while also testing the limit of how often their chip can be reused. In the near-term, the research has applications in the spatial positioning of biomolecules, such as proteins, for research purposes. Long-term, it might even transform information technology: "I would not be surprised if this methodology is used to fabricate the next generation of microprocessors that can push Moore's law even further," Saaem says.

The AVS 58th International Symposium & Exhibition will be held Oct. 30 - Nov. 4 at the Nashville Convention Center.

Presentation BI-MoM10, "DNA Origami from Inkjet Synthesis Produced Strands," is at 11:20 a.m. on Monday, Oct. 31.

####

For more information, please click here

Contacts:
Catherine Meyers

301-209-3088

Copyright © American Institute of Physics

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Main meeting website:

Technical Program:

Related News Press

News and information

Scientists refine formula for nanotube types: Rice University theorists determine factors that give tubes their chiral angles September 17th, 2014

New non-invasive technique could revolutionize the imaging of metastatic cancer September 17th, 2014

Toward making lithium-sulfur batteries a commercial reality for a bigger energy punch September 17th, 2014

Recruiting bacteria to be technology innovation partners: September 17th, 2014

Synthetic Biology

Artificial Cells Act Like the Real Thing: Cell-like compartments produce proteins and communicate with one another, similar to natural biological systems August 18th, 2014

Carnegie Mellon Chemists Create Nanofibers Using Unprecedented New Method July 31st, 2014

Artificial cilia: Scientists from Kiel University develop nano-structured transportation system July 4th, 2014

Artificial enzyme mimics the natural detoxification mechanism in liver cells: Molybdenum oxide particles can assume the function of the endogenous enzyme sulfite oxidase / Basis for new therapeutic application June 30th, 2014

Discoveries

Scientists refine formula for nanotube types: Rice University theorists determine factors that give tubes their chiral angles September 17th, 2014

New non-invasive technique could revolutionize the imaging of metastatic cancer September 17th, 2014

Toward making lithium-sulfur batteries a commercial reality for a bigger energy punch September 17th, 2014

Recruiting bacteria to be technology innovation partners: September 17th, 2014

Announcements

New NPZ100-403 Piezo Stage from nPoint Inc. September 17th, 2014

Scientists refine formula for nanotube types: Rice University theorists determine factors that give tubes their chiral angles September 17th, 2014

New non-invasive technique could revolutionize the imaging of metastatic cancer September 17th, 2014

Toward making lithium-sulfur batteries a commercial reality for a bigger energy punch September 17th, 2014

Events/Classes

PEN Inc. Chairman, Scott Rickert, Will Webcast a Live Company Update September 25, 1 PM EDT September 17th, 2014

Dolomite to launch Meros TCU-100 temperature controller at Lab-on-a-Chip & Microarray World Congress September 15th, 2014

Seeking Nanoscale Defenses for Biological and Chemical Threats: WPI co-organizes a NATO workshop to improve the detection and decontamination of biological and chemical agents September 13th, 2014

PETA science consortium experts to present at international nanotechology workshop: PETA International Science Consortium, Ltd., Is a Sponsor of Nano Risk Analysis II September 12th, 2014

Nanobiotechnology

Recruiting bacteria to be technology innovation partners: September 17th, 2014

NanoStruck has a High Recovery Rate on Mine Tailings: retrieval of up to 96% of Gold, 88% of Silver and 86% of Palladium September 12th, 2014

Boosting armor for nuclear-waste eating microbes September 12th, 2014

Researchers Create World’s Largest DNA Origami September 11th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE