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Home > News > Canadian researchers make inroads into ALS treatment

September 21st, 2011

Canadian researchers make inroads into ALS treatment

Abstract:
A team of British Columbia and Alberta scientists says its discovery that Lou Gehrig's disease progresses by spreading misshapen proteins paves the way for the first treatment for the disease that paralyzes and kills most patients within five years.

Their study, published in the Proceedings of the National Academy of Sciences, suggests protein misfolding at the cellular or molecular level in Lou Gehrig's disease, formally known as amyotrophic lateral sclerosis or ALS, also could trigger the progressive mental and physical deterioration that occurs in brain degenerative diseases, such as Parkinson's and Alzheimer's.

Such protein misfolding is the hallmark of prion diseases such as Creutzfeldt Jakob Disease in humans, chronic wasting disease in deer and elk and mad cow disease in cattle. Prions are infectious agents that are misfolded proteins, rather than bacteria or viruses.

Source:
canada.com

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