Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Bone Marrow Gets Targeted Drug Delivery

Abstract:
Bone marrow, the spongy, flexible tissue found in the center of bones, is essential for the production of blood cells. There are multiple diseases and infections that involve the bone marrow, but current strategies to treat these disorders involve intravenous delivery of drugs are not specifically targeted to the diseased marrow. The healthy cells in the body are also affected, leading to toxic side effects. Thus, there is an urgent need to develop targeted drug delivery strategies to diseased cells in the bone marrow.

Bone Marrow Gets Targeted Drug Delivery

Germany | Posted on August 19th, 2011

Recently, efforts in development of targeted drug delivery has heavily involved nanotechnology, which uses the strategy of active targeting. Porous silicon is an attractive material because of its biocompatibility and ability to carry various agents, from proteins to drugs and nanoparticles. In a new study featured in Advanced Healthcare Materials, Mauro Ferrari, David Gorenstein and their colleagues developed a system comprising nanoporous silicon particles and a cell adhesion molecule that specifically targets bone marrow and delivers a high amount of nanoparticles containing therapeutic drugs to the bone marrow tissue. The cell adhesion molecule, E-selectin, has recently shown promise as a biological target for the delivery of drug carriers to the bone marrow endothelium. The researchers attached a ligand that has a very high affinity to E-selectin to a porous silicon particle and successfully demonstrated its ability to deliver therapeutic liposomes.

These findings have the potential to further develop techniques to deliver currently available drugs specifically to the bone marrow, decreasing their side effects and improving their overall effectiveness in treating bone marrow associated disorders.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

A. P. Mann et al., Adv. Mater., 2011 ; DOI: 10.1002/adma.201101541

Related News Press

News and information

Oxford Instruments and Dresden High Magnetic Field Laboratory collaborate to develop HTS magnet technology components for high field superconducting magnet systems June 29th, 2016

Texas A&M Chemist Says Trapped Electrons To Blame For Lack Of Battery Efficiency: Forget mousetraps — today’s scientists will get the cheese if they manage to build a better battery June 28th, 2016

Building a smart cardiac patch: 'Bionic' cardiac patch could one day monitor and respond to cardiac problems June 28th, 2016

New, better way to build circuits for world's first useful quantum computers June 28th, 2016

Nanomedicine

Building a smart cardiac patch: 'Bionic' cardiac patch could one day monitor and respond to cardiac problems June 28th, 2016

Nanoscientists develop the 'ultimate discovery tool': Rapid discovery power is similar to what gene chips offer biology June 25th, 2016

Nanotechnology and math deliver two-in-one punch for cancer therapy resistance June 24th, 2016

Self-assembling icosahedral protein designed: Self-assembling icosahedral protein designed June 22nd, 2016

Discoveries

Texas A&M Chemist Says Trapped Electrons To Blame For Lack Of Battery Efficiency: Forget mousetraps — today’s scientists will get the cheese if they manage to build a better battery June 28th, 2016

Building a smart cardiac patch: 'Bionic' cardiac patch could one day monitor and respond to cardiac problems June 28th, 2016

New, better way to build circuits for world's first useful quantum computers June 28th, 2016

Yale researchers’ technology turns wasted heat into power June 27th, 2016

Announcements

Oxford Instruments and Dresden High Magnetic Field Laboratory collaborate to develop HTS magnet technology components for high field superconducting magnet systems June 29th, 2016

Texas A&M Chemist Says Trapped Electrons To Blame For Lack Of Battery Efficiency: Forget mousetraps — today’s scientists will get the cheese if they manage to build a better battery June 28th, 2016

Building a smart cardiac patch: 'Bionic' cardiac patch could one day monitor and respond to cardiac problems June 28th, 2016

New, better way to build circuits for world's first useful quantum computers June 28th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic