Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Bone Marrow Gets Targeted Drug Delivery

Abstract:
Bone marrow, the spongy, flexible tissue found in the center of bones, is essential for the production of blood cells. There are multiple diseases and infections that involve the bone marrow, but current strategies to treat these disorders involve intravenous delivery of drugs are not specifically targeted to the diseased marrow. The healthy cells in the body are also affected, leading to toxic side effects. Thus, there is an urgent need to develop targeted drug delivery strategies to diseased cells in the bone marrow.

Bone Marrow Gets Targeted Drug Delivery

Germany | Posted on August 19th, 2011

Recently, efforts in development of targeted drug delivery has heavily involved nanotechnology, which uses the strategy of active targeting. Porous silicon is an attractive material because of its biocompatibility and ability to carry various agents, from proteins to drugs and nanoparticles. In a new study featured in Advanced Healthcare Materials, Mauro Ferrari, David Gorenstein and their colleagues developed a system comprising nanoporous silicon particles and a cell adhesion molecule that specifically targets bone marrow and delivers a high amount of nanoparticles containing therapeutic drugs to the bone marrow tissue. The cell adhesion molecule, E-selectin, has recently shown promise as a biological target for the delivery of drug carriers to the bone marrow endothelium. The researchers attached a ligand that has a very high affinity to E-selectin to a porous silicon particle and successfully demonstrated its ability to deliver therapeutic liposomes.

These findings have the potential to further develop techniques to deliver currently available drugs specifically to the bone marrow, decreasing their side effects and improving their overall effectiveness in treating bone marrow associated disorders.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

A. P. Mann et al., Adv. Mater., 2011 ; DOI: 10.1002/adma.201101541

Related News Press

News and information

Bosch announces high-performance MEMS acceleration sensors for wearables June 27th, 2017

Nanometrics to Participate in the 9th Annual CEO Investor Summit 2017: Accredited investor and publishing research analyst event held concurrently with SEMICON West and Intersolar 2017 in San Francisco June 27th, 2017

NMRC, University of Nottingham chooses the Quorum Q150 coater for its reliable and reproducible film thickness when coating samples with iridium June 27th, 2017

Picosunís ALD solutions enable novel high-speed memories June 27th, 2017

Nanomedicine

Physicists make quantum leap in understanding life's nanoscale machinery June 27th, 2017

Researchers developed nanoparticle based contrast agent for dual modal imaging of cancer June 21st, 2017

Learning with light: New system allows optical ďdeep learningĒ: Neural networks could be implemented more quickly using new photonic technology June 12th, 2017

Mussels add muscle to biocompatible fibers: Rice University chemists develop hydrogel strings using compound found in sea creatures June 9th, 2017

Discoveries

Physicists make quantum leap in understanding life's nanoscale machinery June 27th, 2017

Picosunís ALD solutions enable novel high-speed memories June 27th, 2017

Atomic imperfections move quantum communication network closer to reality June 25th, 2017

Research accelerates quest for quicker, longer-lasting electronics: UC Riverside-led research makes topological insulators magnetic well above room temperatures June 25th, 2017

Announcements

Bosch announces high-performance MEMS acceleration sensors for wearables June 27th, 2017

Nanometrics to Participate in the 9th Annual CEO Investor Summit 2017: Accredited investor and publishing research analyst event held concurrently with SEMICON West and Intersolar 2017 in San Francisco June 27th, 2017

NMRC, University of Nottingham chooses the Quorum Q150 coater for its reliable and reproducible film thickness when coating samples with iridium June 27th, 2017

Picosunís ALD solutions enable novel high-speed memories June 27th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project