Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > "Smart” polymer capsules for dual-responsive drug delivery

Abstract:
Targeted drug delivery has grown into an extensively studied research field exploring methods which allow selective or protected drug/tissue interactions. Triggered release systems based on the presence of physiological stimuli, such as pH, enzymes and redox-potential, have recently emerged for advanced therapeutic delivery applications.

"Smart” polymer capsules for dual-responsive drug delivery

Melbourne, Australia | Posted on August 11th, 2011

Professor Frank Caruso and co-workers (University of Melbourne) have demonstrated how several independent release mechanisms can be brought together and synergistically function to tune cargo release profiles. They were able to generate a novel class of polymeric nano/microcapsules with dual-responsive release mechanisms via the versatile layer-by-layer technique and click chemistry.

These capsules could release cargo specifically in pH conditions that mimic intracellular acidic compartments. Further, the synergistic effects of pH and redox-potential allowed for rapid and efficient cargo release, even for extremely low intracellular reducing agent concentrations. The simple and efficient combination of the layer-by-layer technique and click chemistry for synthesizing "big-to-small" capsules with dual stimuli-responsive cargo release mechanisms broadens the possibilities for the design of "smart" capsules for intracellular therapeutic and diagnostic applications.

####

For more information, please click here

Copyright © John Wiley & Sons

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

K. Liang et al, Adv. Mater. ; DOI: 10.1002/adma.201101690

Related News Press

News and information

Cryo-electron microscopy achieves unprecedented resolution using new computational methods March 25th, 2017

Argon is not the 'dope' for metallic hydrogen March 24th, 2017

Promising results obtained with a new electrocatalyst that reduces the need for platinum: Researchers from Aalto University have succeeded in manufacturing electrocatalysts used for storing electric energy with one-hundredth of the amount of platinum that is usually needed March 24th, 2017

Artificial photosynthesis steps into the light: Rice University lab turns transition metals into practical catalyst for solar, other applications March 23rd, 2017

Nanomedicine

Cryo-electron microscopy achieves unprecedented resolution using new computational methods March 25th, 2017

Nanobiotix: The Independent Data Monitoring Committee Recommends the Continuation of the Ongoing Phase II/III Trial of NBTXR3 in Soft Tissue Sarcoma March 23rd, 2017

Nanoparticle paves the way for new triple negative breast cancer drug March 20th, 2017

Block copolymer micellization as a protection strategy for DNA origami March 17th, 2017

Discoveries

Cryo-electron microscopy achieves unprecedented resolution using new computational methods March 25th, 2017

Argon is not the 'dope' for metallic hydrogen March 24th, 2017

Promising results obtained with a new electrocatalyst that reduces the need for platinum: Researchers from Aalto University have succeeded in manufacturing electrocatalysts used for storing electric energy with one-hundredth of the amount of platinum that is usually needed March 24th, 2017

Artificial photosynthesis steps into the light: Rice University lab turns transition metals into practical catalyst for solar, other applications March 23rd, 2017

Announcements

Cryo-electron microscopy achieves unprecedented resolution using new computational methods March 25th, 2017

Argon is not the 'dope' for metallic hydrogen March 24th, 2017

Promising results obtained with a new electrocatalyst that reduces the need for platinum: Researchers from Aalto University have succeeded in manufacturing electrocatalysts used for storing electric energy with one-hundredth of the amount of platinum that is usually needed March 24th, 2017

Artificial photosynthesis steps into the light: Rice University lab turns transition metals into practical catalyst for solar, other applications March 23rd, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project