Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > Nanoparticle therapeutics might help people suffering from hearing disorders

Abstract:
For millions of people hearing disorders make a negative impact on their lives. Scientists are looking into new ways of treating hearing disorders, by using different sorts of nanoparticles as original inner ear delivery devices. Their hope is that nanoparticles will be able to deliver drugs that can improve or restore hearing.

Nanoparticle therapeutics might help people suffering from hearing disorders

Italy | Posted on June 13th, 2011

Due to different anatomic and physiological barriers it is hard to treat hearing disorders by using conventional systemic drug delivery. Therefore scientists are investigating different ways to locally apply drugs using nanoparticles. Researchers at Guangdong Pharmaceutical University in China highlight that several nanoparticles have a combination of properties, such as target specificity, stability in vivo, biocompatibility and capacity to incorporate the encapsulated drugs into the cell, making it possible to use smaller doses and reduce the side effects of therapeutic agents. They anticipate that nanoparticles will play an extremely important role in the development of drug delivery systems, which can find the desired target sites and release the drugs in a controlled way within the cell.

In the European Commission-funded project NANOEAR, scientists from several countries in Europe are studying where different nanoparticles go within the inner ear and if these nanoparticles could be harmful or useful in therapeutics. They are currently testing eight nanoparticle classes, for example, biodegradable liposomes, micelles and lipid-core nanocapsules, regarding their delivery of genes, peptides, corticosteroids, siRNA and shRNA. Since nanoparticles also have properties that separate them, the researchers need to find the best carrier for each drug.

The project‚s researchers are working on nanoparticles targeted towards hair cells, neurons and supporting cells. They have identified fundamental peptides helping the nanoparticles to avoid being trapped and dysfunctionalized by the lysosomal enzymes in the cell‚s endosome system, so the nanoparticles are able to deliver the therapeutic drugs to their targets. Nanoparticles can be modified with coatings to escape immune responses. Three of NANOEAR‚s partners are focusing on safety and they have not observed any adverse reactions.

Within the consortium, researchers at the Medical University of Innsbruck in Austria studied nanoparticles conjugated with a neurotrophin-derived peptide ligand. They found that these nanoparticles selectively targeted the mouse inner ear cells and can potentially be used as inner ear drug delivery devices.

Many research projects are in the early stage development. There will be rigorous controls and take years until patients may be helped by the innovations. However, if the researchers manage to make these nanoparticles do exactly what they are made to do, nanoparticle therapeutics will radically change the way hearing disorders are treated.

####

For more information, please click here

Contacts:
Elisabeth Schmid
Phone: +39 02 70002 572
Fax: +39 02 70002 540
E-mail:

Copyright © youris.com

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Researchers show what drives a novel, ordered assembly of alternating peptides February 20th, 2020

CEA-Leti and CEA-IRIG Demonstrate Quantum Integrated Circuit Combining Quantum Dot with Digital-Analog Circuits on CMOS Chip: Presentation at ISSCC 2020 Shows Role FD-SOI Can Play in Embedding Qubit Arrays with Classic Electronics to Build Large-Scale Quantum Silicon Processors February 20th, 2020

CEA-Leti Presents High-Performance Processor Breakthrough With Active Interposer and 3D Stacked Chiplets at ISSCC 2020 February 19th, 2020

New green technology from UMass Amherst generates electricity 'out of thin air' Renewable device could help mitigate climate change, power medical devices February 17th, 2020

Nanomedicine

Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain: Researchers Butantan Institute succeeded in reducing the toxicity and potentiating the analgesic effect of crotoxin by encapsulating it in nanostructured silica -- the results of tests in an anim February 14th, 2020

Gold nanoclusters: new frontier for developing medication for treatment of Alzheimer's disease February 14th, 2020

Nanotech company granted FDA Fast Track for treatment of head & neck cancer February 10th, 2020

Arrowhead Reports Interim Clinical Data on Cardiometabolic Candidates ARO-APOC3 and ARO-ANG3 February 5th, 2020

Discoveries

Researchers show what drives a novel, ordered assembly of alternating peptides February 20th, 2020

New green technology from UMass Amherst generates electricity 'out of thin air' Renewable device could help mitigate climate change, power medical devices February 17th, 2020

Does graphene cause or prevent the corrosion of copper? New study finally settles the debate: Scientists in Korea are first to observe an unprecedented way in which graphene forms a hybrid layer that prevents copper corrosion February 14th, 2020

KIST unveils the mystery of van der Waals magnets, a material for future semiconductors: Overcoming the limits of current magnetic materials, giving hope for development of next-generation semiconductors February 14th, 2020

Announcements

CEA-Leti and CEA-IRIG Demonstrate Quantum Integrated Circuit Combining Quantum Dot with Digital-Analog Circuits on CMOS Chip: Presentation at ISSCC 2020 Shows Role FD-SOI Can Play in Embedding Qubit Arrays with Classic Electronics to Build Large-Scale Quantum Silicon Processors February 20th, 2020

CEA-Leti Presents High-Performance Processor Breakthrough With Active Interposer and 3D Stacked Chiplets at ISSCC 2020 February 19th, 2020

New green technology from UMass Amherst generates electricity 'out of thin air' Renewable device could help mitigate climate change, power medical devices February 17th, 2020

KIST unveils the mystery of van der Waals magnets, a material for future semiconductors: Overcoming the limits of current magnetic materials, giving hope for development of next-generation semiconductors February 14th, 2020

Alliances/Trade associations/Partnerships/Distributorships

New European Project to Fast-Track Adoption Of Cyber-Physical Systems (CPS) by SMEs: DigiFed to Demonstrate Potential of CPS Digital Technologies in Hardware Security, Human-Machine Interaction, and Autonomy for Small & Midsized Companies January 29th, 2020

American Chemical Society names Philip Proteau as new editor-in-chief of the Journal of Natural Products January 24th, 2020

American Chemical Society names Dr. James Milne head of its Publications Division January 24th, 2020

Nexeon Updates on SUNRISE Project: Next Generation Battery Materials Project Exceeding Expectations January 6th, 2020

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project