Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanoparticle therapeutics might help people suffering from hearing disorders

Abstract:
For millions of people hearing disorders make a negative impact on their lives. Scientists are looking into new ways of treating hearing disorders, by using different sorts of nanoparticles as original inner ear delivery devices. Their hope is that nanoparticles will be able to deliver drugs that can improve or restore hearing.

Nanoparticle therapeutics might help people suffering from hearing disorders

Italy | Posted on June 13th, 2011

Due to different anatomic and physiological barriers it is hard to treat hearing disorders by using conventional systemic drug delivery. Therefore scientists are investigating different ways to locally apply drugs using nanoparticles. Researchers at Guangdong Pharmaceutical University in China highlight that several nanoparticles have a combination of properties, such as target specificity, stability in vivo, biocompatibility and capacity to incorporate the encapsulated drugs into the cell, making it possible to use smaller doses and reduce the side effects of therapeutic agents. They anticipate that nanoparticles will play an extremely important role in the development of drug delivery systems, which can find the desired target sites and release the drugs in a controlled way within the cell.

In the European Commission-funded project NANOEAR, scientists from several countries in Europe are studying where different nanoparticles go within the inner ear and if these nanoparticles could be harmful or useful in therapeutics. They are currently testing eight nanoparticle classes, for example, biodegradable liposomes, micelles and lipid-core nanocapsules, regarding their delivery of genes, peptides, corticosteroids, siRNA and shRNA. Since nanoparticles also have properties that separate them, the researchers need to find the best carrier for each drug.

The project‚s researchers are working on nanoparticles targeted towards hair cells, neurons and supporting cells. They have identified fundamental peptides helping the nanoparticles to avoid being trapped and dysfunctionalized by the lysosomal enzymes in the cell‚s endosome system, so the nanoparticles are able to deliver the therapeutic drugs to their targets. Nanoparticles can be modified with coatings to escape immune responses. Three of NANOEAR‚s partners are focusing on safety and they have not observed any adverse reactions.

Within the consortium, researchers at the Medical University of Innsbruck in Austria studied nanoparticles conjugated with a neurotrophin-derived peptide ligand. They found that these nanoparticles selectively targeted the mouse inner ear cells and can potentially be used as inner ear drug delivery devices.

Many research projects are in the early stage development. There will be rigorous controls and take years until patients may be helped by the innovations. However, if the researchers manage to make these nanoparticles do exactly what they are made to do, nanoparticle therapeutics will radically change the way hearing disorders are treated.

####

For more information, please click here

Contacts:
Elisabeth Schmid
Phone: +39 02 70002 572
Fax: +39 02 70002 540
E-mail:

Copyright © youris.com

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Basque researchers turn light upside down February 23rd, 2018

Stiffness matters February 23rd, 2018

Imaging individual flexible DNA 'building blocks' in 3-D: Berkeley Lab researchers generate first images of 129 DNA structures February 22nd, 2018

'Memtransistor' brings world closer to brain-like computing: Combined memristor and transistor can process information and store memory with one device February 22nd, 2018

Nanomedicine

Stiffness matters February 23rd, 2018

Histology in 3-D: New staining method enables Nano-CT imaging of tissue samples February 22nd, 2018

Imaging individual flexible DNA 'building blocks' in 3-D: Berkeley Lab researchers generate first images of 129 DNA structures February 22nd, 2018

Arrowhead Receives Regulatory Clearance to Begin Phase 1 Study of ARO-AAT for Treatment of Alpha-1 Liver Disease February 22nd, 2018

Discoveries

Basque researchers turn light upside down February 23rd, 2018

Histology in 3-D: New staining method enables Nano-CT imaging of tissue samples February 22nd, 2018

Developing reliable quantum computers February 22nd, 2018

Imaging individual flexible DNA 'building blocks' in 3-D: Berkeley Lab researchers generate first images of 129 DNA structures February 22nd, 2018

Announcements

Basque researchers turn light upside down February 23rd, 2018

Stiffness matters February 23rd, 2018

Histology in 3-D: New staining method enables Nano-CT imaging of tissue samples February 22nd, 2018

Developing reliable quantum computers February 22nd, 2018

Alliances/Trade associations/Partnerships/Distributorships

New era in high field superconducting magnets – opening new frontiers in science, nanotechnology and materials discovery January 9th, 2018

Leti Field Trials Demonstrate New Multicarrier Waveform for Rural, Maritime Broadband Radio: Field Trial in Orkney Islands Used New Filtered Multicarrier Waveform at 700MHz Band with Flexible Bandwidth Usage (Fragmented and Continuous Spectrum) December 18th, 2017

A new product to help combat mouldy walls, thanks to technology developed at the ICN2 December 14th, 2017

JPK Instruments announce partnership with Swiss company, Cytosurge AG. The partnership makes Cytosurge’s FluidFM® technology available on the JPK NanoWizard® AFM platform December 8th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project