Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

android tablet pc

Home > Press > Manhattan Scientifics & Senior Scientific Cancer Project Enters Clinical Trial

- The Technology was Described in "THE GRAY SHEET" Publication

- "The Gray Sheet" Provides In-Depth Specialized Coverage of the Medical Device, Diagnostic & Instrumentation Industries

- Article Notes Active Partnering Discussions with Large Drug, Device and Imaging Companies

Manhattan Scientifics & Senior Scientific Cancer Project Enters Clinical Trial

Albuquerque, NM | Posted on March 21st, 2011

Manhattan Scientifics, Inc. (OTCBB: MHTX) said today that "The Gray Sheet" has written about an initial clinical trial that has enrolled its first 35 patients to measure leukemia cells using a unique nanotechnology-based magnetic imaging method developed by Senior Scientific LLC, which has licensed the technology to Manhattan Scientifics, Inc.

An authorized copy of the article authored by Zach Miners follows:

Nanotechnology Cancer Detection Technology Moves To Clinical Trial

A first-in-man clinical trial to measure very small levels of residual leukemia cells using a unique nanotechnology-based magnetic imaging method has enrolled its first 35 patients.

The technology, in development by Senior Scientific and nanomedicine-focused investment firm Manhattan Scientifics, is still years from reaching the market, but the firms say they are in active partnering discussions with several large drug, device and imaging companies.

The trial, which will enroll 60 patients in all, is expected to be completed within two years. In leukemia, the focus is on monitoring the effect of chemotherapy by detecting residual disease. The technique also has applications in gauging therapy response in a range of other cancers, according to the developers.

"If you're doing chemotherapy, hyperthermia or even surgery, we can use our device to see that you get it all," said Edward Flynn, founder and president of Senior Scientific. "The leukemia case is just one example."

The companies are also assessing the tool for early detection of breast cancer, other malignancies and Alzheimer's disease, he said.

Magnetically Measuring Cancer Cells

The technique being studied in the leukemia trial involves first extracting bone marrow cells from leukemia patients; injecting the cell sample with magnetic nanoparticles linked to antigens that preferentially bind to leukemia cells rather than normal cells; and measuring the concentration of leukemia cells in the sample by employing a patented magnetic biopsy needle and a specialized sensor array for magnetic fields.

Flynn says the technology can detect "minimal residual disease" down to 0.3% of a sample. Achieving that level of sensitivity is the primary endpoint of the study, which is being conducted at the University of New Mexico's Health Sciences Center. Comparatively, current biopsy techniques typically fail to detect leukemia cells that account for less than 5% of a sample, he notes.

Detecting the presence of minimal residual disease provides information on how well chemotherapy is working, and when it might be appropriate to stop treatment or change doses or drugs. More refined monitoring of chemotherapy is particularly important in pediatric leukemia, Flynn says, because the treatments can have significant short- and long-term adverse effects on the young patients.

Flynn also specifically pressed the promise of the technology for early detection of breast cancer, noting that magnetic nanoparticle- based detection can localize a breast tumor containing 100,000 cells - or 1/1000th of what a mammogram requires.

The magnetic-based detection also limits the potential for false positives and is not affected by the presence of scar tissue from surgeries and implants, he points out.

In Vivo Approach Is Next Step

Ultimately, Flynn says the goal is to perform the technique by an in vivo approach, where the antigen-linked nanoparticles are injected into the body, providing a means to detect the precise location of cancer cells.

This presents a potential strategy for monitoring tumor evolution. As the tumor grows or shrinks, for instance, the number of nanoparticles bound to the cancer cells also grows or shrinks and could be promptly measured, Flynn suggests.

It also could allow for more targeted chemotherapy, limiting adverse effects of widespread treatment.

"It's a smart-bombing approach," explains Marvin Maslow, founder and chairman emeritus at Manhattan Scientifics.

In February 2010, Manhattan acquired rights to all commercial applications of the technology, which was developed by Flynn.

Flynn, a nuclear physicist by training, founded privately held Senior Scientific in 1996 to develop magnetic-based cancer cell detection. The firm has received $7 million in research grants from the National Institutes of Health since 2002, mostly through the Small Business Innovation Research program.


About Manhattan Scientifics, Inc.
Manhattan Scientifics Inc. ( operates with locations in New Mexico, New York, and Montreal. The company's goal is to advance and commercialize disruptive technologies to create profit for its shareholders in the field of nano-medicine.

Forward-looking statement

This press release contains forward-looking statements, which are subject to a number of risks, assumptions and uncertainties that could cause the Company's actual results to differ materially from those projected in such forward-looking statements. Management at Manhattan Scientifics believes that purchase of its shares should be considered to be at the high end of the risk spectrum. Forward-looking statements speak only as of the date made and are not guarantees of future performance. We undertake no obligation to publicly update or revise any forward-looking statements.

For more information, please click here

Manhattan Scientifics, Inc.
Stanton Public Relations & Marketing
Michael Kassin, 212-366-5300

Manhattan Scientifics:
Marvin Maslow 917-923-3300

Senior Scientific:
Edward R. Flynn, Ph.D

U.S. & Canadian Investor Relations:
Hawk Associates
Frank Hawkins, 305-451-1888
European Contact:
Herbert Strauss, +43-316-296-316
email: herbert"at"

Copyright © Business Wire

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

East China University of Science and Technology Purchases Nanonex Advanced Nanoimprint Tool NX-B200 July 30th, 2014

Watching Schrödinger's cat die (or come to life): Steering quantum evolution & using probes to conduct continuous error correction in quantum computers July 30th, 2014

From Narrow to Broad July 30th, 2014

FLAG-ERA and TNT2014 join efforts: Graphene Networking at its higher level in Barcelona: Encourage the participation in a joint transnational call July 30th, 2014


New imaging agent provides better picture of the gut July 30th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014


University of Manchester selects Anasys AFM-IR for coatings and corrosion research July 30th, 2014

Nature inspires a greener way to make colorful plastics July 30th, 2014

Analytical solutions from Malvern Instruments support University of Wisconsin-Milwaukee researchers in understanding environmental effects of nanomaterials July 30th, 2014

FEI Unveils New Solutions for Faster Time-to-Analysis in Metals Research July 30th, 2014

The latest news from around the world, FREE

  Premium Products
Only the news you want to read!
 Learn More
University Technology Transfer & Patents
 Learn More
Full-service, expert consulting
 Learn More

Nanotechnology Now Featured Books


The Hunger Project

© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE