Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Using chitosan derivatives to determine bactericidal activity

Abstract:
Researchers at National Nanotechnology Center, NANOTEC in Thailand, are doing research on the effects of the degree of quaternization, molecular weight and ratio of N-methylpyridinium and N,N,N-trimethyl ammonium moieties on bactericidal activity by introducing quaternization of N-(3-pyridylmethyl) chitosan derivatives.

Using chitosan derivatives to determine bactericidal activity

Pathumthani, Thailand | Posted on March 11th, 2011

"We found that the bactericidal activity was dependent on the chemical structure of quaternary ammonium moiety and the molecular weight, at constant DQ" said Dr. Warayuth Sajomsang, one of the research team members. "The result revealed that the N,N,N-trimethyl ammonium group showed higher bactericidal activity than the N-methylpyridinium group at similar DQ and molecular weight. Moreover, the bactericidal activity of M3-PyMeChC tended to decrease with decreasing molecular weight from 82 kDa to 8 kDa, at DQ of 802%".

"The bactericidal tests were performed in accordance with the National Committee for Clinical Laboratory Standards (NCCLS) to determine broth microdilution minimum inhibitory concentration (MIC) values" said Dr. Uracha Ruktanonchai, another member of the research team. "The microorganisms used in the inhibitory test were obtained from the Department of Medical Sciences (Ministry of Public Health, Thailand). The microorganisms used in this study were Staphylococcus aureus ATCC 6538 as a model for Grampositive bacteria and Escherichia coli ATCC 25922 as a model for Gram-negative bacteria".

The researchers reported their work in a paper published by Elsevier. The researchers at the NanoDelivery lab are currently working on research projects using nanoencapsulation and molecular complexation for controlled release and target delivery of bioactive compounds.

####

For more information, please click here

Contacts:
Ramjitti Indaraprasirt
Manager
International Relations Section
NANOTEC
02-564-7100 ext: 6617

113 Thailand Science Park
Phaholyothin Rd.
Klong 1, Klong Luang
Pathumthani 12120
Thailand

Copyright © NANOTEC

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

CubeSat Structures Competition Opens Space Design to Students of the World December 16th, 2017

Record high photoconductivity for new metal-organic framework material December 15th, 2017

Error-free into the quantum computer age December 15th, 2017

Leti Will Demonstrate First 3D Anti-Crash Solution for Embedding in Drones: Fitted on a Mass-Market Microcontroller, 360Fusion Software Technology Detects any Dynamic Obstacle and Helps Guide Drones Away from Collisions December 15th, 2017

Nanomedicine

Synthetic protein packages its own genetic material and evolves computationally designed protein assemblies are advancing research in synthetic life and in targeted drug delivery December 15th, 2017

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Leti to Demo Wristband with Embedded Sensors to Diagnose Sleep Apnea: APNEAband, Which Will Be Demonstrated at CES 2018, Also Monitors Mountain Sickness, Dehydration, Dialysis Treatment Response and Epileptic Seizures December 12th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Discoveries

Quantum memory with record-breaking capacity based on laser-cooled atoms December 15th, 2017

Record high photoconductivity for new metal-organic framework material December 15th, 2017

Error-free into the quantum computer age December 15th, 2017

Synthetic protein packages its own genetic material and evolves computationally designed protein assemblies are advancing research in synthetic life and in targeted drug delivery December 15th, 2017

Announcements

CubeSat Structures Competition Opens Space Design to Students of the World December 16th, 2017

Record high photoconductivity for new metal-organic framework material December 15th, 2017

Error-free into the quantum computer age December 15th, 2017

Leti Will Demonstrate First 3D Anti-Crash Solution for Embedding in Drones: Fitted on a Mass-Market Microcontroller, 360Fusion Software Technology Detects any Dynamic Obstacle and Helps Guide Drones Away from Collisions December 15th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project