Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Hydrogels used to make precise new sensor

This diagram depicts a new type of "diffraction-based" sensor made of thin stripes of a gelatinous material called a hydrogel, which expands and contracts depending on the acidity of its environment. The new type of biological and chemical sensor has few moving parts and works by precisely determining pH, revealing the identity of substances in liquid environments such as water or blood. The microscopic images at bottom show how the hydrogel stripes expand with decreasing acidity. (Birck Nanotechnology Center, Purdue University)
This diagram depicts a new type of "diffraction-based" sensor made of thin stripes of a gelatinous material called a hydrogel, which expands and contracts depending on the acidity of its environment. The new type of biological and chemical sensor has few moving parts and works by precisely determining pH, revealing the identity of substances in liquid environments such as water or blood. The microscopic images at bottom show how the hydrogel stripes expand with decreasing acidity. (Birck Nanotechnology Center, Purdue University)

Abstract:
Researchers are developing a new type of biological and chemical sensor that has few moving parts, is low-cost and yet highly sensitive, sturdy and long-lasting.

Hydrogels used to make precise new sensor

West Lafayette, IN | Posted on February 8th, 2011

The "diffraction-based" sensors are made of thin stripes of a gelatinous material called a hydrogel, which expands and contracts depending on the acidity of its environment.

Recent research findings have demonstrated that the sensor can be used to precisely determine pH - a measure of how acidic or basic a liquid is - revealing information about substances in liquid environments, said Cagri Savran (pronounced Chary Savran), an associate professor of mechanical engineering at Purdue University.

The sensor's simple design could make it more practical than other sensors in development, he said.

"Many sensors being developed today are brilliantly designed but are too expensive to produce, require highly skilled operators and are not robust enough to be practical," said Savran, whose work is based at Purdue's Birck Nanotechnology Center in the university's Discovery Park.

New findings show the technology is highly sensitive and might be used in chemical and biological applications including environmental monitoring in waterways and glucose monitoring in blood.

"As with any novel platform, more development is needed, but the detection principle behind this technology is so simple that it wouldn't be difficult to commercialize," said Savran, who is collaborating with another team of researchers led by Babak Ziaie, a Purdue professor of electrical and computer engineering and biomedical engineering.

Findings are detailed in a paper presented during the IEEE Sensors 2010 Conference in November and also published in the conference proceedings. The paper was written by postdoctoral researcher Chun-Li Chang, doctoral student Zhenwen Ding, Ziaie and Savran.

The flexible, water-insoluble hydrogel is formed into a series of raised stripes called a "diffraction grating," which is coated with gold on both the stripe surfaces and the spaces in between. The stripes expand and contract depending on the pH level of the environment.

Researchers in Ziaie's lab fabricated the hydrogel, while Savran's group led work in the design, development and testing of the diffraction-based sensor.

The sensors work by analyzing laser light reflecting off the gold coatings. Reflections from the stripes and spaces in between interfere with each other, creating a "diffraction pattern" that differs depending on the height of the stripes.

These diffraction patterns indicate minute changes in the movement of the hydrogel stripes in response to the environment, in effect measuring changes in pH.

"By precise measurement of pH, the diffraction patterns can reveal a lot of information about the sample environment," said Savran, who by courtesy is an associate professor of biomedical engineering and electrical and computer engineering. "This technology detects very small changes in the swelling of the diffraction grating, which makes them very sensitive."

The pH of a liquid is recorded on a scale from 0 to 14, with 0 being the most acidic and 14 the most basic. Findings showed the device's high sensitivity enables it to resolve changes smaller than one-1,000th on the pH scale, measuring swelling of only a few nanometers. A nanometer is about 50,000 times smaller than the finest sand grain.

"We know we can make them even more sensitive," Savran said. "By using different hydrogels, gratings responsive to stimuli other than pH can also be fabricated."

The work is ongoing.

"It's a good example of collaborations that can blossom when labs focusing on different research are located next to each other," Savran said. "Professor Ziaie's lab was already working with hydrogels, and my group was working on diffraction-based sensors. Hearing about the hydrogels work next door, one of my postdoctoral researchers, Chun-Li Chang thought of making a reflective diffraction grating out of hydrogels."

The Office of Technology Commercialization of the Purdue Research Foundation has filed for U.S. patent protection on the concept.

ABSTRACT

Diffractometric Biochemical Sensing with Smart Hydrogels


Chun-Li Changab, Zhenwen Dingbc, Venkata N. L. R. Patchigollaab, Babak Ziaiebd, and Cagri A. Savranab

aSchool of Mechanical Engineering, bBirck Nanotechnology Center, cDepartment of Physics, dSchool of Electrical and Computer Engineering, Purdue University


We report reflective diffraction gratings made from smart hydrogels for ultrasensitive biochemical detection. As an example for a biochemically responsive hydrogel, we chose a pH-sensitive hydrogel to construct diffraction gratings that swell or shrink due to changes in pH. Interferometric analysis of the grating enabled detection of the hydrogel's swelling/shrinking with nanoscale precision with a resolution of 610-4 pH units. The developed system is remarkably simple both to fabricate and operate. Moreover, the concept of the hydrogel grating is generic and can be widely applied to hydrogels responsive to other stimuli.

####

For more information, please click here

Contacts:
Writer:
Emil Venere
765-494-4709


Sources:
Cagri A. Savran
765 494-8601


Babak Ziaie
765-494-0725


Copyright © Purdue University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Non-animal approach to predict impact of nanomaterials on human lung published Archives of Toxicology publishes workshop recommendations May 2nd, 2016

Making invisible physics visible: The Jayich Lab has created a new sensor technology that captures nanoscale images with high spatial resolution and sensitivity May 2nd, 2016

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Spintronics for future information technologies: Spin currents in topological insulators controlled May 2nd, 2016

Possible Futures

Making invisible physics visible: The Jayich Lab has created a new sensor technology that captures nanoscale images with high spatial resolution and sensitivity May 2nd, 2016

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Academic/Education

JPK reports on the use of a NanoWizard AFM system at the University of Kaiserslautern to study the interaction of bacteria with microstructured surfaces April 28th, 2016

The Ottawa Hospital Research Institute uses the ZetaView from Particle Metrix to study membrane microparticles as potential biomarkers for underlying diseases April 12th, 2016

FEI Partners with Five Pharmaceutical Companies, the Medical Research Council and the University of Cambridge to form Cryo-EM Research Consortium April 5th, 2016

SUNY Poly, in Collaboration with the George Washington School of Medicine and Health Sciences and Stony Brook University, Demonstrates Pioneering Method to Visualize and Identify Engineered Nanoparticles in Tissue March 25th, 2016

Sensors

Making invisible physics visible: The Jayich Lab has created a new sensor technology that captures nanoscale images with high spatial resolution and sensitivity May 2nd, 2016

Electrically Conductive Graphene Ink Enables Printing of Biosensors April 23rd, 2016

Highlights from the Graphene Flagship April 22nd, 2016

Team builds first quantum cascade laser on silicon: Eliminates the need for an external light source for mid-infrared silicon photonic devices or photonic circuits April 21st, 2016

Announcements

Non-animal approach to predict impact of nanomaterials on human lung published Archives of Toxicology publishes workshop recommendations May 2nd, 2016

Making invisible physics visible: The Jayich Lab has created a new sensor technology that captures nanoscale images with high spatial resolution and sensitivity May 2nd, 2016

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Spintronics for future information technologies: Spin currents in topological insulators controlled May 2nd, 2016

Environment

Team builds first quantum cascade laser on silicon: Eliminates the need for an external light source for mid-infrared silicon photonic devices or photonic circuits April 21st, 2016

Atomically thin sensor detects harmful air pollution in the home April 18th, 2016

Catalyst could make production of key chemical more eco-friendly April 10th, 2016

Nanoporous material's strange "breathing" behavior April 7th, 2016

Water

Nanoparticles present sustainable way to grow food crops May 1st, 2016

Novel anti-biofilm nano coating developed at Ben-Gurion U.: Offers significant anti-adhesive potential for a variety of medical and industrial applications April 25th, 2016

Adding some salt to the recipe for energy storage materials: Researchers use common table salt as growth template April 22nd, 2016

NRL reveals novel uniform coating process of p-ALD April 21st, 2016

Nanobiotechnology

New drug-delivery approach holds potential for treating obesity May 2nd, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Arrowhead Pharmaceuticals Files for Regulatory Clearance to Begin Phase 1/2 Study of ARC-521 April 28th, 2016

The Translational Research Center at the University Hospital of Erlangen in Germany uses the ZetaView from Particle Metrix to quantify extracellular vesicles such as exosomes April 28th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic