Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanosponges Harvest Rare Cancer Marker from Blood

Abstract:
Cancer researchers have long hypothesized that tumors release small amounts of proteins that could serve as earlier diagnostic indicators of cancer, but the search for such biomarkers has been hampered by the presence of large quantities of other proteins, such albumin, found in the blood and by the fact that these trace proteins are often unstable in blood. Now, an international research team from the United States and Italy has shown that it can use a new type of nanoparticle to selectively trap specific families of proteins from blood and protect them from degradation by enzymes in blood.

Nanosponges Harvest Rare Cancer Marker from Blood

Bethesda, MD | Posted on January 19th, 2011

Lance Liotta of George Mason University and Caterina Longo from the University of Moderna and Regio Emilia led this investigation. The U.S. and Italian team published its findings in the journal Experimental Dermatology.

Previously, this research team had developed a set of highly porous nanoparticles whose interiors were decorated with different types of "bait" molecules that could selectively harvest large families of low-abundance proteins from blood. These nanoparticles were designed to exclude the relatively large protein-degrading enzymes prevalent in blood, and hence, could protect the trapped proteins from being broken down before they could be analyzed. In this set of experiments, the investigators used the particles to collect potential biomarkers for melanoma from the blood of human patients with this aggressive form of skin cancer. The researchers obtained blood from 29 patients with primary and metastatic melanoma as well as 26 patients with strange-looking moles that had not developed into melanomas.

The researchers found that levels of one particular protein, known as Bak, correlated highly with the development of moles into melanomas. These results were confirmed by histological examination of moles and melanoma tumors. The investigators note that although more patients need to be tested to confirm these results, it appears that serum Bak levels, measured after capture using these nanoparticles, could serve as a prognostic indicator for melanoma. The broader impact of this study lies with the demonstration that these baited nanoparticles can trap and protect rare proteins in human clinical blood samples and release those proteins for subsequent analysis for disease biomarkers.

This work, which was supported in part by the National Cancer Institute, is detailed in a paper titled, "A novel biomarker harvesting nanotechnology identifies Bak as a candidate melanoma biomarker in serum." An abstract of this paper is available through PubMed.

View abstract www.ncbi.nlm.nih.gov/pubmed/21158936

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

The relationship between charge density waves and superconductivity? It's complicated July 19th, 2018

Sirrus's Issued Patent Portfolio Continues To Accelerate July 18th, 2018

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Academic/Education

The Institute of Applied Physics at the University of Tsukuba near Tokyo in Japan uses Deben's ARM2 detector to better understand catalytic reaction mechanisms June 27th, 2018

Powering the 21st Century with Integrated Photonics: UCSB-Led Team Selected for Demonstration of a Novel Waveguide Platform Which is Transparent Throughout the MWIR and LWIR Spectral Bands June 19th, 2018

SUNY Poly Professor Eric Lifshin Selected for ‘Fellow of the Microanalysis Society’ Position for Significant Contributions to Microanalysis June 13th, 2018

Grand Opening of UC Irvine Materials Research Institute (IMRI) to Spotlight JEOL Center for Nanoscale Solutions: Renowned Materials Scientists to Present at the 1st International Symposium on Advanced Microscopy and Spectroscopy (ISAMS) April 18th, 2018

Nanomedicine

Nano-kirigami: 'Paper-cut' provides model for 3D intelligent nanofabrication July 13th, 2018

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment July 11th, 2018

New sensor technology enables super-sensitive live monitoring of human biomolecules July 3rd, 2018

Announcements

The relationship between charge density waves and superconductivity? It's complicated July 19th, 2018

Sirrus's Issued Patent Portfolio Continues To Accelerate July 18th, 2018

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Nanobiotechnology

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment July 11th, 2018

New sensor technology enables super-sensitive live monitoring of human biomolecules July 3rd, 2018

Arrowhead Presents New Clinical Data on ARO-AAT at Alpha-1 National Education Conference July 1st, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project