Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Purdue, NIST working on breathalyzers for medical diagnostics

This image shows a new type of sensor for an advanced breath-analysis technology that rapidly diagnoses patients by detecting "biomarkers" in a person's respiration in real time. Researchers used a template made of micron-size polymer particles and coated them with much smaller metal oxide nanoparticles. Using nanoparticle-coated microparticles instead of a flat surface allows researchers to increase the porosity of the sensor films, increasing the "active sensing surface area" to improve sensitivity. (Purdue University and NIST)
This image shows a new type of sensor for an advanced breath-analysis technology that rapidly diagnoses patients by detecting "biomarkers" in a person's respiration in real time. Researchers used a template made of micron-size polymer particles and coated them with much smaller metal oxide nanoparticles. Using nanoparticle-coated microparticles instead of a flat surface allows researchers to increase the porosity of the sensor films, increasing the "active sensing surface area" to improve sensitivity. (Purdue University and NIST)

Abstract:
Researchers have overcome a fundamental obstacle in developing breath-analysis technology to rapidly diagnose patients by detecting chemical compounds called "biomarkers" in a person's respiration in real time.

Purdue, NIST working on breathalyzers for medical diagnostics

West Lafayette, IN | Posted on January 3rd, 2011

The researchers demonstrated their approach is capable of rapidly detecting biomarkers in the parts per billion to parts per million range, at least 100 times better than previous breath-analysis technologies, said Carlos Martinez, an assistant professor of materials engineering at Purdue who is working with researchers at the National Institute of Standards and Technology.

"People have been working in this area for about 30 years but have not been able to detect low enough concentrations in real time," he said. "We solved that problem with the materials we developed, and we are now focusing on how to be very specific, how to distinguish particular biomarkers."

The technology works by detecting changes in electrical resistance or conductance as gases pass over sensors built on top of "microhotplates," tiny heating devices on electronic chips. Detecting biomarkers provides a record of a patient's health profile, indicating the possible presence of cancer and other diseases.

"We are talking about creating an inexpensive, rapid way of collecting diagnostic information about a patient," Martinez said. "It might say, 'there is a certain percentage that you are metabolizing a specific compound indicative of this type of cancer,' and then additional, more complex tests could be conducted to confirm the diagnosis."

The researchers used the technology to detect acetone, a biomarker for diabetes, with a sensitivity in the parts per billion range in a gas mimicking a person's breath.

Findings were detailed in a research paper that appeared earlier this year in the IEEE Sensors Journal, published by the Institute of Electrical and Electronics Engineers' IEEE Sensors Council. The paper was co-authored by Martinez and NIST researchers Steve Semancik, lead author Kurt D. Benkstein, Baranidharan Raman and Christopher B. Montgomery.

The researchers used a template made of micron-size polymer particles and coated them with far smaller metal oxide nanoparticles. Using nanoparticle-coated microparticles instead of a flat surface allows researchers to increase the porosity of the sensor films, increasing the "active sensing surface area" to improve sensitivity.

A droplet of the nanoparticle-coated polymer microparticles was deposited on each microhotplate, which are about 100 microns square and contain electrodes shaped like meshing fingers. The droplet dries and then the electrodes are heated up, burning off the polymer and leaving a porous metal-oxide film, creating a sensor.

"It's very porous and very sensitive," Martinez said. "We showed that this can work in real time, using a simulated breath into the device."

Gases passing over the device permeate the film and change its electrical properties depending on the particular biomarkers contained in the gas.

Such breathalyzers are likely a decade or longer away from being realized, in part because precise standards have not yet been developed to manufacture devices based on the approach, Martinez said.

"However, the fact that we were able to do this in real time is a big step in the right direction," he said.

####

For more information, please click here

Contacts:
Writer:
Emil Venere
765-494-4709


Source:
Carlos Martinez
765-494-3271

Copyright © Purdue University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Novel Electrode Structure Provides New Promise for Lithium-Sulfur Batteries December 3rd, 2016

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Possible Futures

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Novel Electrode Structure Provides New Promise for Lithium-Sulfur Batteries December 3rd, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Academic/Education

Oxford Nanoimaging report on how the Nanoimager, a desktop microscope delivering single molecule, super-resolution performance, is being applied at the MRC Centre for Molecular Bacteriology & Infection November 22nd, 2016

The University of Applied Sciences in Upper Austria uses Deben tensile stages as an integral part of their computed tomography research and testing facility October 18th, 2016

Enterprise In Space Partners with Sketchfab and 3D Hubs for NewSpace Education October 13th, 2016

New Agricultural Research Center Debuts at UCF October 12th, 2016

Nanomedicine

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

From champagne bubbles, dance parties and disease to new nanomaterials: Understanding nucleation of protein filaments might help with Alzheimer's Disease and type 2 Diabetes November 24th, 2016

Nanopolymer-modified protein array can pinpoint hard-to-find cancer biomarker November 17th, 2016

Announcements

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Novel Electrode Structure Provides New Promise for Lithium-Sulfur Batteries December 3rd, 2016

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Nanobiotechnology

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

From champagne bubbles, dance parties and disease to new nanomaterials: Understanding nucleation of protein filaments might help with Alzheimer's Disease and type 2 Diabetes November 24th, 2016

Making spintronic neurons sing in unison November 18th, 2016

Research partnerships

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Novel silicon etching technique crafts 3-D gradient refractive index micro-optics November 28th, 2016

Single photon converter -- a key component of quantum internet November 28th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project