Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Expandable Nanoparticles Show Promise in Treating Lethal Abdominal Cavity Tumors

Abstract:
Too often, patients with ovarian cancer or mesothelioma develop metastases that spread within the abdominal cavity, and when that occurs, the chances of surviving beyond five years drops to less than 40%, even after surgical removal of the metastatic tumors. In attempt to develop a new therapeutic approach to treating peritoneal metastases, a research team at Boston University has developed a novel, drug-loaded polymeric nanoparticle that responds to the acidic pH inside tumor cells by expanding, releasing the anticancer agent paclitaxel slowly over a period of 24 hours. Tests with these new nanoparticles demonstrated that they not only decreased tumor growth, but prevented new tumors from implanting themselves in the abdominal cavity.

Expandable Nanoparticles Show Promise in Treating Lethal Abdominal Cavity Tumors

Bethesda, MD | Posted on November 30th, 2010

Mark Grinstaff led the research team that published its work in the journal Biomaterials. Investigators from Brigham and Women's Hospital also participated in this study.

The goal of the investigator's efforts was to create a nanoparticle that would release paclitaxel only when taken up by tumors, release drug slowly to maximize the number of dividing cells exposed to the drug, and that would remain in the vicinity of the tumors while it released drug. The investigators prepared their cross-linked polymeric nanoparticles using a technique known as mini-emulsion polymerization to create a material that remains intact but swells at the low pH characteristic of tumor cells. Tests with paclitaxel-loaded nanoparticles showed that they release about 4% of their drug load each hour for 24 hours, creating a sustained load of drug in the vicinity of the nanoparticle. When added to mesothelioma cells growing in culture, the drug-loaded nanoparticles showed substantial cell-killing activity.

Based on these initial results, the investigators treated mice that had an aggressive form of mesothelioma with their nanoparticles, free paclitaxel, or paclitaxel loaded into a similar, but not expandable, nanoparticle. Only the expandable nanoparticles produced a substantial reduction in tumor mass and disease severity scores. Moreover, only the drug-loaded expandable nanoparticles prevented the development of peritoneal tumor implants. Finally, animals treated with the drug-loaded expandable nanoparticles survived nearly twice as long as did animals treated with free paclitaxel, the current therapy of choice for peritoneal tumors. Other experiments conducted by the investigators showed that when injected into the abdominal cavity, the drug-loaded expandable nanoparticles homed to tumor sites and remained there for at least seven days.

####

About The National Cancer Institute (NCI)
The NCI Alliance for Nanotechnology in Cancer is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Center for Strategic Scientific Initiatives
ATTN: NCI Office of Cancer Nanotechnology Research (OCNR)
Building 31, Room 10A52
31 Center Drive, MSC 2580
Bethesda, MD 20892-2580
(301) 451-8983

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - "The performance of expansile nanoparticles in a murine model of peritoneal carcinomatosis."

Related News Press

News and information

Successful boron-doping of graphene nanoribbon August 27th, 2015

Nanolab Technologies LEAPS Forward with High-Performance Analysis Services to the World: Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division August 27th, 2015

National Space Society Welcomes Janet Ivey As New NSS Governor: Janet Ivey of Janet's Planet is NOW IN ORBIT as a member of the Board of Governors of the National Space Society August 27th, 2015

Researchers combine disciplines, computational programs to determine atomic structure August 26th, 2015

Govt.-Legislation/Regulation/Funding/Policy

These microscopic fish are 3-D-printed to do more than swim: Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities August 26th, 2015

Glitter from silver lights up Alzheimer's dark secrets August 25th, 2015

Southampton scientists find new way to detect ortho-para conversion in water August 25th, 2015

Industrial Nanotech, Inc. Provides Update On Hospital Project, PCAOB Audit, and New Heat Shield™ Line August 24th, 2015

Nanomedicine

These microscopic fish are 3-D-printed to do more than swim: Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities August 26th, 2015

Glitter from silver lights up Alzheimer's dark secrets August 25th, 2015

Cervical cancer detection goes portable August 25th, 2015

Louisiana Tech University researchers discover synthesis of a new nanomaterial: Interdisciplinary team creates biocomposite for first time using physiological conditions August 24th, 2015

Discoveries

Successful boron-doping of graphene nanoribbon August 27th, 2015

These microscopic fish are 3-D-printed to do more than swim: Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities August 26th, 2015

Researchers combine disciplines, computational programs to determine atomic structure August 26th, 2015

Developing Component Scale Composites Using Nanocarbons August 26th, 2015

Announcements

Successful boron-doping of graphene nanoribbon August 27th, 2015

Nanolab Technologies LEAPS Forward with High-Performance Analysis Services to the World: Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division August 27th, 2015

National Space Society Welcomes Janet Ivey As New NSS Governor: Janet Ivey of Janet's Planet is NOW IN ORBIT as a member of the Board of Governors of the National Space Society August 27th, 2015

Researchers combine disciplines, computational programs to determine atomic structure August 26th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic