Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Atherosclerosis Nanotoolbox: NIH Awards $14.6M Translational Cardiovascular Nanomedicine Center for Detecting and Treating Atherosclerosis

Gang Bao Biomedical Engineering

As director of the Center for Translational Cardiovascular Nanomedicine, Gang Bao will lead a research team in developing nanotechnology and biomolecular engineering tools and methodologies for detecting and treating atherosclerosis. (Photo: Gary Meek)
Gang Bao Biomedical Engineering As director of the Center for Translational Cardiovascular Nanomedicine, Gang Bao will lead a research team in developing nanotechnology and biomolecular engineering tools and methodologies for detecting and treating atherosclerosis. (Photo: Gary Meek)

Abstract:
Georgia Tech and Emory University have received a five-year $14.6 million contract from the National Institutes of Health (NIH) to continue the development of nanotechnology and biomolecular engineering tools and methodologies for detecting and treating atherosclerosis.

by Abby Vogel Robinson

Atherosclerosis Nanotoolbox: NIH Awards $14.6M Translational Cardiovascular Nanomedicine Center for Detecting and Treating Atherosclerosis

Atlanta, GA | Posted on October 5th, 2010

Atherosclerosis typically occurs in branched or curved regions of arteries where plaques form because of cholesterol build-up. Inflammation can alter the structure of plaques so they become more likely to rupture, potentially causing a blood vessel blockage and leading to heart attack or stroke.

The award will support the interdisciplinary Center for Translational Cardiovascular Nanomedicine as the second phase of the Program of Excellence in Nanotechnology (PEN), originally established in 2005 with funding from the National Heart, Lung, and Blood Institute of the NIH. This Center integrates the biomedical engineering expertise of Georgia Tech and the cardiology strengths of Emory University's School of Medicine. The broad and long-term goal of the PEN is to improve the diagnosis and treatment of cardiovascular disease, which is the leading cause of death for men and women in the United States.

"In the last five years, we developed a suite of nanotechnology approaches for diagnosing and treating cardiovascular disease and we have demonstrated their efficacy in terms of potential clinical application," said Gang Bao, the program's director and the Robert A. Milton Chair in Biomedical Engineering in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. "For the next five years, we will focus on translating these technologies into clinical utility and we would like to have some of these nanotechnologies ready for human clinical trials by the end of this five-year period."

During the first five years of the PEN, the Georgia Tech and Emory University researchers have made contributions in nanotechnology development, basic cardiology research and inflammatory biomarker detection. The research team has published or submitted more than 80 peer-reviewed papers, filed nine patents and established three startup companies to commercialize the nanotechnologies.

"There is a great unmet need to develop innovative diagnostic modalities that inform the activity of the inflammatory disease and to guide evaluation of therapy," explained Bao, who is also a Georgia Tech College of Engineering Distinguished Professor. "Our nanotechnology toolbox will allow us to translate more mature nanotechnologies to clinical utility and evaluate new nanotechnologies that will provide unique functionalities and novel applications."

The second phase of the PEN will build on the foundation developed and progress made during the last five years to accomplish four goals:

Using nanoparticle probes to image and characterize atherosclerotic plaques
Diagnosing cardiovascular disease from a blood sample
Designing new methods for delivering anti-atherosclerosis drugs and genes into the body
Developing stem cell based therapies to repair damaged heart tissue

The researchers will use the suite of nanotechnologies they developed in the last five years -- including molecular beacons, magnetic nanoparticles, gold nanoparticles, quantum dots, polyketals and hydrocyanine dyes -- to accomplish these goals.

The first goal focuses on determining if an individual's atherosclerotic plaque will grow and rupture. Having this information would allow physicians to treat atherosclerosis more effectively.

"By using nanoparticle probes in vitro and in vivo, we hope to be able to detect early-stage cardiovascular disease," noted Bao, "but many important issues such as detection specificity, toxicity and safety still need to be addressed."

In addition to in vivo imaging of plaques using magnetic resonance imaging (MRI) and positron emission tomography (PET), the research team is developing a laboratory diagnostic test for detecting cardiovascular disease from a blood sample. The presence or levels of specific micro-RNAs, reactive oxygen species or protein markers in the blood will be tested as an indication of the presence and stage of atherosclerosis. This diagnostic approach has the advantages of being fast, inexpensive and nontoxic.

Once atherosclerosis is detected in an individual, it needs to be treated. Several small molecule drugs have been identified as potent therapeutic agents for cardiovascular diseases, but their clinical utility is limited due to their water-repellant nature and short circulation half-life. A novel approach for targeted drug or gene delivery is to use nanoparticles to carry the small molecules into the body. This type of delivery system has the advantage of combining targeting, imaging and controlled release, and can be tailored to optimize circulation time and reduce toxicity.

"Delivering these small molecules in a specific, sufficient and sustained manner to localized vascular lesions may significantly improve the clinical outcomes of cardiovascular diseases," said Bao.

For the final goal, the research team will use stem cells to create a personalized treatment strategy for repairing damage caused by atherosclerosis. The researchers plan to use nanotechnologies to generate and deliver patient-specific induced pluripotent stem cells to the injured vasculature and heart to repair the damage.

"Our goals are ambitious as we plan to further develop our nanoscale tools and nanocardiology knowledge base, to translate the new tools and nanotechnologies to clinical applications in diagnosing and treating cardiovascular disease, and to train the next generation of leaders in cardiovascular nanomedicine," added Bao.

Also contributing from the Coulter Department are professors Don Giddens, Xiaoping Hu, Hanjoong Jo, Shuming Nie, and W. Robert Taylor; associate professors Niren Murthy and May Dongmei Wang; and assistant professor Michael Davis. Giddens is also dean of Georgia Tech's College of Engineering. Taylor is also the director of Emory's Division of Cardiology and a member of the Atlanta VA Medical Center's Division of Cardiology.

Contributors from Emory University include Department of Medicine chair Wayne Alexander; Division of Cardiology professors David Harrison and Kathy Griendling, associate professor Young-sup Yoon and assistant professor Charles Searles Jr.; and Department of Radiology professor Mark Goodman. Katherine Ferrara, a biomedical engineering professor at the University of California, Davis, is also collaborating on the project.

####

For more information, please click here

Contacts:
Media Relations Contacts:
Abby Vogel Robinson

404-385-3364
or
John Toon

404-894-6986

Copyright © Georgia Institute of Technology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Dressing a metal in various colors: DGIST research developed a technology to coat metal with several nanometers of semiconducting materials January 17th, 2017

Nanoparticle exposure can awaken dormant viruses in the lungs January 17th, 2017

Nanoscale view of energy storage January 16th, 2017

Seeing the quantum future... literally: What if big data could help you see the future and prevent your mobile phone from breaking before it happened? January 16th, 2017

Govt.-Legislation/Regulation/Funding/Policy

Nanoscale view of energy storage January 16th, 2017

Chemistry on the edge: Experiments at Berkeley Lab confirm that structural defects at the periphery are key in catalyst function January 13th, 2017

Recreating conditions inside stars with compact lasers: Scientists offer a new path to creating the extreme conditions found in stars, using ultra-short laser pulses irradiating nanowires January 12th, 2017

Deciphering the beetle exoskeleton with nanomechanics: Understanding exoskeletons could lead to new, improved artificial materials January 12th, 2017

Possible Futures

Dressing a metal in various colors: DGIST research developed a technology to coat metal with several nanometers of semiconducting materials January 17th, 2017

Nanoscale view of energy storage January 16th, 2017

Seeing the quantum future... literally: What if big data could help you see the future and prevent your mobile phone from breaking before it happened? January 16th, 2017

NUS researchers achieve major breakthrough in flexible electronics: New classes of printable electrically conducting polymer materials make better electrodes for plastic electronics and advanced semiconductor devices January 14th, 2017

Academic/Education

Oxford Nanoimaging report on how the Nanoimager, a desktop microscope delivering single molecule, super-resolution performance, is being applied at the MRC Centre for Molecular Bacteriology & Infection November 22nd, 2016

The University of Applied Sciences in Upper Austria uses Deben tensile stages as an integral part of their computed tomography research and testing facility October 18th, 2016

Enterprise In Space Partners with Sketchfab and 3D Hubs for NewSpace Education October 13th, 2016

New Agricultural Research Center Debuts at UCF October 12th, 2016

Nanomedicine

New active filaments mimic biology to transport nano-cargo: A new design for a fully biocompatible motility engine transports colloidal particles faster than diffusion with active filaments January 11th, 2017

Keystone Nano Announces FDA Approval Of Investigational New Drug Application For Ceramide NanoLiposome For The Improved Treatment Of Cancer January 10th, 2017

Captured on video: DNA nanotubes build a bridge between 2 molecular posts: Research may lead to new lines of direct communication with cells January 9th, 2017

Arrowhead Provides Response to New Minority Shareholder Announcement January 7th, 2017

Announcements

Dressing a metal in various colors: DGIST research developed a technology to coat metal with several nanometers of semiconducting materials January 17th, 2017

Nanoparticle exposure can awaken dormant viruses in the lungs January 17th, 2017

Nanoscale view of energy storage January 16th, 2017

Seeing the quantum future... literally: What if big data could help you see the future and prevent your mobile phone from breaking before it happened? January 16th, 2017

Nanobiotechnology

Nanoscale Modifications can be used to Engineer Electrical Contacts for Nanodevices January 13th, 2017

New active filaments mimic biology to transport nano-cargo: A new design for a fully biocompatible motility engine transports colloidal particles faster than diffusion with active filaments January 11th, 2017

Keystone Nano Announces FDA Approval Of Investigational New Drug Application For Ceramide NanoLiposome For The Improved Treatment Of Cancer January 10th, 2017

Captured on video: DNA nanotubes build a bridge between 2 molecular posts: Research may lead to new lines of direct communication with cells January 9th, 2017

Research partnerships

Chemistry on the edge: Experiments at Berkeley Lab confirm that structural defects at the periphery are key in catalyst function January 13th, 2017

Recreating conditions inside stars with compact lasers: Scientists offer a new path to creating the extreme conditions found in stars, using ultra-short laser pulses irradiating nanowires January 12th, 2017

Zeroing in on the true nature of fluids within nanocapillaries: While exploring the behavior of fluids at the nanoscale, a group of researchers at the French National Center for Scientific Research discovered a peculiar state of fluid mixtures contained in microscopic channels January 11th, 2017

New active filaments mimic biology to transport nano-cargo: A new design for a fully biocompatible motility engine transports colloidal particles faster than diffusion with active filaments January 11th, 2017

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project