Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Atherosclerosis Nanotoolbox: NIH Awards $14.6M Translational Cardiovascular Nanomedicine Center for Detecting and Treating Atherosclerosis

Gang Bao Biomedical Engineering

As director of the Center for Translational Cardiovascular Nanomedicine, Gang Bao will lead a research team in developing nanotechnology and biomolecular engineering tools and methodologies for detecting and treating atherosclerosis. (Photo: Gary Meek)
Gang Bao Biomedical Engineering As director of the Center for Translational Cardiovascular Nanomedicine, Gang Bao will lead a research team in developing nanotechnology and biomolecular engineering tools and methodologies for detecting and treating atherosclerosis. (Photo: Gary Meek)

Abstract:
Georgia Tech and Emory University have received a five-year $14.6 million contract from the National Institutes of Health (NIH) to continue the development of nanotechnology and biomolecular engineering tools and methodologies for detecting and treating atherosclerosis.

by Abby Vogel Robinson

Atherosclerosis Nanotoolbox: NIH Awards $14.6M Translational Cardiovascular Nanomedicine Center for Detecting and Treating Atherosclerosis

Atlanta, GA | Posted on October 5th, 2010

Atherosclerosis typically occurs in branched or curved regions of arteries where plaques form because of cholesterol build-up. Inflammation can alter the structure of plaques so they become more likely to rupture, potentially causing a blood vessel blockage and leading to heart attack or stroke.

The award will support the interdisciplinary Center for Translational Cardiovascular Nanomedicine as the second phase of the Program of Excellence in Nanotechnology (PEN), originally established in 2005 with funding from the National Heart, Lung, and Blood Institute of the NIH. This Center integrates the biomedical engineering expertise of Georgia Tech and the cardiology strengths of Emory University's School of Medicine. The broad and long-term goal of the PEN is to improve the diagnosis and treatment of cardiovascular disease, which is the leading cause of death for men and women in the United States.

"In the last five years, we developed a suite of nanotechnology approaches for diagnosing and treating cardiovascular disease and we have demonstrated their efficacy in terms of potential clinical application," said Gang Bao, the program's director and the Robert A. Milton Chair in Biomedical Engineering in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. "For the next five years, we will focus on translating these technologies into clinical utility and we would like to have some of these nanotechnologies ready for human clinical trials by the end of this five-year period."

During the first five years of the PEN, the Georgia Tech and Emory University researchers have made contributions in nanotechnology development, basic cardiology research and inflammatory biomarker detection. The research team has published or submitted more than 80 peer-reviewed papers, filed nine patents and established three startup companies to commercialize the nanotechnologies.

"There is a great unmet need to develop innovative diagnostic modalities that inform the activity of the inflammatory disease and to guide evaluation of therapy," explained Bao, who is also a Georgia Tech College of Engineering Distinguished Professor. "Our nanotechnology toolbox will allow us to translate more mature nanotechnologies to clinical utility and evaluate new nanotechnologies that will provide unique functionalities and novel applications."

The second phase of the PEN will build on the foundation developed and progress made during the last five years to accomplish four goals:

• Using nanoparticle probes to image and characterize atherosclerotic plaques
• Diagnosing cardiovascular disease from a blood sample
• Designing new methods for delivering anti-atherosclerosis drugs and genes into the body
• Developing stem cell based therapies to repair damaged heart tissue

The researchers will use the suite of nanotechnologies they developed in the last five years -- including molecular beacons, magnetic nanoparticles, gold nanoparticles, quantum dots, polyketals and hydrocyanine dyes -- to accomplish these goals.

The first goal focuses on determining if an individual's atherosclerotic plaque will grow and rupture. Having this information would allow physicians to treat atherosclerosis more effectively.

"By using nanoparticle probes in vitro and in vivo, we hope to be able to detect early-stage cardiovascular disease," noted Bao, "but many important issues such as detection specificity, toxicity and safety still need to be addressed."

In addition to in vivo imaging of plaques using magnetic resonance imaging (MRI) and positron emission tomography (PET), the research team is developing a laboratory diagnostic test for detecting cardiovascular disease from a blood sample. The presence or levels of specific micro-RNAs, reactive oxygen species or protein markers in the blood will be tested as an indication of the presence and stage of atherosclerosis. This diagnostic approach has the advantages of being fast, inexpensive and nontoxic.

Once atherosclerosis is detected in an individual, it needs to be treated. Several small molecule drugs have been identified as potent therapeutic agents for cardiovascular diseases, but their clinical utility is limited due to their water-repellant nature and short circulation half-life. A novel approach for targeted drug or gene delivery is to use nanoparticles to carry the small molecules into the body. This type of delivery system has the advantage of combining targeting, imaging and controlled release, and can be tailored to optimize circulation time and reduce toxicity.

"Delivering these small molecules in a specific, sufficient and sustained manner to localized vascular lesions may significantly improve the clinical outcomes of cardiovascular diseases," said Bao.

For the final goal, the research team will use stem cells to create a personalized treatment strategy for repairing damage caused by atherosclerosis. The researchers plan to use nanotechnologies to generate and deliver patient-specific induced pluripotent stem cells to the injured vasculature and heart to repair the damage.

"Our goals are ambitious as we plan to further develop our nanoscale tools and nanocardiology knowledge base, to translate the new tools and nanotechnologies to clinical applications in diagnosing and treating cardiovascular disease, and to train the next generation of leaders in cardiovascular nanomedicine," added Bao.

Also contributing from the Coulter Department are professors Don Giddens, Xiaoping Hu, Hanjoong Jo, Shuming Nie, and W. Robert Taylor; associate professors Niren Murthy and May Dongmei Wang; and assistant professor Michael Davis. Giddens is also dean of Georgia Tech's College of Engineering. Taylor is also the director of Emory's Division of Cardiology and a member of the Atlanta VA Medical Center's Division of Cardiology.

Contributors from Emory University include Department of Medicine chair Wayne Alexander; Division of Cardiology professors David Harrison and Kathy Griendling, associate professor Young-sup Yoon and assistant professor Charles Searles Jr.; and Department of Radiology professor Mark Goodman. Katherine Ferrara, a biomedical engineering professor at the University of California, Davis, is also collaborating on the project.

####

For more information, please click here

Contacts:
Media Relations Contacts:
Abby Vogel Robinson

404-385-3364
or
John Toon

404-894-6986

Copyright © Georgia Institute of Technology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Transparent, electrically conductive network of encapsulated silver nanowires: A novel electrode for optoelectronics August 1st, 2015

Harris & Harris Group Portfolio Company, HZO, Announces Partnerships with Dell and Motorola August 1st, 2015

Advances and Applications in Biosensing, Sensor Power, and Sensor R&D to be Covered at Sensors Global Summit August 1st, 2015

Kalam: versatility personified August 1st, 2015

Govt.-Legislation/Regulation/Funding/Policy

Self-assembling, biomimetic membranes may aid water filtration August 1st, 2015

Kalam: versatility personified August 1st, 2015

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

Theoretical Physicists at Freie Universität Berlin Develop New Insights into Interface between Classical and Quantum Worlds July 31st, 2015

Possible Futures

Nanofiltration Membrane Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Nanozirconia Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Self-Healing Nano Anti-rust Coatings Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Nano Spray Instrument Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Academic/Education

Pakistani Students Who Survived Terror Attack to Attend Weeklong “NanoDiscovery Institute” at SUNY Poly CNSE in Albany July 29th, 2015

Deben reports on the use of their CT500 in the X-ray microtomography laboratory at La Trobe University, Melbourne, Australia July 22nd, 2015

JPK reports on the use of SPM in the Messersmith Group at UC Berkeley looking at biologically inspired polymer adhesives. July 21st, 2015

Renishaw adds Raman analysis to Scanning Electron Microscopy at the University of Sydney, Australia July 9th, 2015

Nanomedicine

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

European Technology Platform for Nanomedicine and ENATRANS European Consortium Launch the 2nd edition of the Nanomedicine Award: The Award to be presented at BIO-Europe conference in Munich, November 2015 July 30th, 2015

Take a trip through the brain July 30th, 2015

Sol-gel capacitor dielectric offers record-high energy storage July 30th, 2015

Announcements

Self-assembling, biomimetic membranes may aid water filtration August 1st, 2015

Transparent, electrically conductive network of encapsulated silver nanowires: A novel electrode for optoelectronics August 1st, 2015

Harris & Harris Group Portfolio Company, HZO, Announces Partnerships with Dell and Motorola August 1st, 2015

Advances and Applications in Biosensing, Sensor Power, and Sensor R&D to be Covered at Sensors Global Summit August 1st, 2015

Nanobiotechnology

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

European Technology Platform for Nanomedicine and ENATRANS European Consortium Launch the 2nd edition of the Nanomedicine Award: The Award to be presented at BIO-Europe conference in Munich, November 2015 July 30th, 2015

New computer model could explain how simple molecules took first step toward life: Two Brookhaven researchers developed theoretical model to explain the origins of self-replicating molecules July 28th, 2015

Spintronics: Molecules stabilizing magnetism: Organic molecules fixing the magnetic orientation of a cobalt surface/ building block for a compact and low-cost storage technology/ publication in Nature Materials July 25th, 2015

Research partnerships

Newly-Developed Polymers Control Size of Nanoparticles during Production Process July 30th, 2015

Meet the high-performance single-molecule diode: Major milestone in molecular electronics scored by Berkeley Lab and Columbia University team July 29th, 2015

Spintronics: Molecules stabilizing magnetism: Organic molecules fixing the magnetic orientation of a cobalt surface/ building block for a compact and low-cost storage technology/ publication in Nature Materials July 25th, 2015

Stretching the limits on conducting wires July 25th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project