Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Novel Chemistry Amplifies Ability of Nanoparticles

Abstract:
Investigators at the Massachusetts General Hospital and Harvard Medical School has developed a chemical methodology that can be used to attach virtually any antibody to a nanoparticle without the need to optimize the reaction conditions.

Novel Chemistry Amplifies Ability of Nanoparticles

Bethesda, MD | Posted on September 20th, 2010

One of the most promising characteristics of nanoparticles as diagnostic agents is the ability to attach to the nanoparticles surface any of a wide variety of targeting molecules that can increase the distinction between malignant and healthy cells, making it easier to spot small numbers of diseased cells within a sea of healthy cells. However, the development of such targeted nanoparticles has been hampered by the need to optimize the chemical methods used to link the targeting molecule to the nanoparticle for each unique combination of the two.

Now, a team of investigators at the Massachusetts General Hospital and Harvard Medical School has developed a chemical methodology that can be used to attach virtually any antibody to a nanoparticle without the need to optimize the reaction conditions. This team, led by Ralph Weissleder, who is a co-principal investigator of the MIT-Harvard Center of Cancer Nanotechnology Excellence, published their findings in the journal Nature Nanotechnology.

Using a nanoparticle that is both magnetic and fluorescent and three different monoclonal antibodies known to target tumor-associated surface molecules, Dr. Weissleder and his collaborators applied what they call "bioorthogonal chemistry" to create nanoparticles that bind strongly to the targeted tumor types. They showed that binding took place with the proper cells using a novel miniaturized magnetic resonance detector system developed by the Weissleder team for use in point-of-care applications.

The investigators then compared the binding ability of their targeted nanoparticles with those prepared using one of the now-standard approaches for linking antibodies to nanoparticles. The new process created nanoparticles that stuck to their targeted cells with 10 to 15 times the avidity of those nanoparticles prepared with standard methods. In addition to improving the sensitivity of tumor cell detection using targeted nanoparticles, this new chemistry could also improve strategies for developing targeted drug delivery applications.

This work, which was supported in part by the National Cancer Institute, is detailed in a paper titled, "Bioorthogonal chemistry amplifies nanoparticle binding and enhances sensitivity of cell detection." An abstract of this paper is available at the journal's Web site.

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

A Stretchy Mesh Heater for Sore Muscles July 6th, 2015

BBC World Service to broadcast Forum discussion on graphene July 6th, 2015

Production of Zirconium Carbide Nanoparticles at Low Temperature without Thermal Operations July 5th, 2015

A 'movie' of ultrafast rotating molecules at a hundred billion per second: A quantum wave-like nature was successfully observed in rotating nitrogen molecules July 4th, 2015

Academic/Education

Oxford Instruments’ TritonXL Cryofree dilution refrigerator selected for the Oxford NQIT Quantum Technology Hub project June 30th, 2015

Rice University boots up powerful microscopes: New electron microscopes will capture images at subnanometer resolution June 29th, 2015

Six top Catalan research centres constitute ‘The Barcelona Institute of Science and Technology’ to pursue a joint scientific endeavour June 27th, 2015

Lancaster University revolutionary quantum technology research receives funding boost June 22nd, 2015

Nanomedicine

A Stretchy Mesh Heater for Sore Muscles July 6th, 2015

New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Iranian Scientists Find Simple, Economic Method to Synthesize Antibacterial Nanoparticles July 2nd, 2015

Announcements

A Stretchy Mesh Heater for Sore Muscles July 6th, 2015

BBC World Service to broadcast Forum discussion on graphene July 6th, 2015

Production of Zirconium Carbide Nanoparticles at Low Temperature without Thermal Operations July 5th, 2015

A 'movie' of ultrafast rotating molecules at a hundred billion per second: A quantum wave-like nature was successfully observed in rotating nitrogen molecules July 4th, 2015

Nanobiotechnology

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Engineering the world’s smallest nanocrystal July 2nd, 2015

Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015

Newly-Developed Biosensor in Iran Detects Cocaine Addiction June 23rd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project