Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Novel Chemistry Amplifies Ability of Nanoparticles

Abstract:
Investigators at the Massachusetts General Hospital and Harvard Medical School has developed a chemical methodology that can be used to attach virtually any antibody to a nanoparticle without the need to optimize the reaction conditions.

Novel Chemistry Amplifies Ability of Nanoparticles

Bethesda, MD | Posted on September 20th, 2010

One of the most promising characteristics of nanoparticles as diagnostic agents is the ability to attach to the nanoparticles surface any of a wide variety of targeting molecules that can increase the distinction between malignant and healthy cells, making it easier to spot small numbers of diseased cells within a sea of healthy cells. However, the development of such targeted nanoparticles has been hampered by the need to optimize the chemical methods used to link the targeting molecule to the nanoparticle for each unique combination of the two.

Now, a team of investigators at the Massachusetts General Hospital and Harvard Medical School has developed a chemical methodology that can be used to attach virtually any antibody to a nanoparticle without the need to optimize the reaction conditions. This team, led by Ralph Weissleder, who is a co-principal investigator of the MIT-Harvard Center of Cancer Nanotechnology Excellence, published their findings in the journal Nature Nanotechnology.

Using a nanoparticle that is both magnetic and fluorescent and three different monoclonal antibodies known to target tumor-associated surface molecules, Dr. Weissleder and his collaborators applied what they call "bioorthogonal chemistry" to create nanoparticles that bind strongly to the targeted tumor types. They showed that binding took place with the proper cells using a novel miniaturized magnetic resonance detector system developed by the Weissleder team for use in point-of-care applications.

The investigators then compared the binding ability of their targeted nanoparticles with those prepared using one of the now-standard approaches for linking antibodies to nanoparticles. The new process created nanoparticles that stuck to their targeted cells with 10 to 15 times the avidity of those nanoparticles prepared with standard methods. In addition to improving the sensitivity of tumor cell detection using targeted nanoparticles, this new chemistry could also improve strategies for developing targeted drug delivery applications.

This work, which was supported in part by the National Cancer Institute, is detailed in a paper titled, "Bioorthogonal chemistry amplifies nanoparticle binding and enhances sensitivity of cell detection." An abstract of this paper is available at the journal's Web site.

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Iranian Researchers Synthesize Stable Ceramic Nanopowders at Room Temperature September 20th, 2014

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

SouthWest NanoTechnologies (SWeNT) Receives NIST Small Business Innovation Research (SBIR) Phase 1 Award to Produce Greater than 99% Semiconducting Single-Wall Carbon Nanotubes September 19th, 2014

Toward optical chips: A promising light source for optoelectronic chips can be tuned to different frequencies September 19th, 2014

Academic/Education

Biosensors Get a Boost from Graphene Partnership: $5 Million Investment Supports Dozens of Jobs and Development of 300mm Fabrication Process and Wafer Transfer Facility September 18th, 2014

Malvern technology delivers Malvern reliability in multi-disciplinary lab at Queen Mary University London September 9th, 2014

State University of New York Trustees Unanimously Approve SUNY Polytechnic Institute (SUNY Poly) as New Name for Merged SUNY CNSE / SUNYIT September 9th, 2014

New Vice President Takes Helm at CNSE CMOST: Catherine Gilbert To Lead CNSE Children’s Museum of Science and Technology Through Expansion And Relocation August 29th, 2014

Nanomedicine

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

The Pocket Project will develop a low-cost and accurate point-of-care test to diagnose Tuberculosis: ICN2 holds a follow-up meeting of the Project on September 18th - 19th September 18th, 2014

New non-invasive technique could revolutionize the imaging of metastatic cancer September 17th, 2014

Recruiting bacteria to be technology innovation partners: September 17th, 2014

Announcements

Iranian Scientists Separate Zinc Ion at Low Concentrations September 20th, 2014

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

SouthWest NanoTechnologies (SWeNT) Receives NIST Small Business Innovation Research (SBIR) Phase 1 Award to Produce Greater than 99% Semiconducting Single-Wall Carbon Nanotubes September 19th, 2014

Toward optical chips: A promising light source for optoelectronic chips can be tuned to different frequencies September 19th, 2014

Nanobiotechnology

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

CiQUS researchers design an artificial nose to detect DNA differentiation with single nucleotide resolution September 18th, 2014

Biosensors Get a Boost from Graphene Partnership: $5 Million Investment Supports Dozens of Jobs and Development of 300mm Fabrication Process and Wafer Transfer Facility September 18th, 2014

Recruiting bacteria to be technology innovation partners: September 17th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE