Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Medicine reaches the target with the help of magnets

Professor Maria Kempe
Professor Maria Kempe

Abstract:
If a drug can be guided to the right place in the body, the treatment is more effective and there are fewer side-effects. Researchers at Lund University in Sweden have now developed magnetic nanoparticles that can be directed to metallic implants such as artificial knee joints, hip joints and stents in the coronary arteries.

Medicine reaches the target with the help of magnets

Sweden | Posted on August 26th, 2010

Associate Professor Maria Kempe, her brother and colleague Dr Henrik Kempe and members of staff at Skåne University Hospital have shown that the principle works in animal experiments.

They have succeeded in attaching a clot-dissolving drug to the nanoparticles and, with the help of magnets, have directed the particles to a blood clot in a stent in the heart to dissolve it. Thus the nanoparticles have been able to stop an incipient heart attack.

A stent is a tube-shaped metal net used to treat narrowing of the coronary arteries. First the artery is expanded using a balloon catheter, then a stent is inserted to keep the artery open. However, the method is not without problems: depending on the type of stent inserted, the cells of the artery wall can grow and again obstruct the artery or a blood clot can develop in the stent.

In the Lund researchers' experiments, the nanoparticles were coated with a drug used to treat blood clots. The particles could also carry other drugs, e.g. drugs to stop the cell growth that makes an artery become narrower.

"They could also carry antibiotics to treat an infection developed after insertion of an implant. We have developed polymer materials that can be loaded with antibiotics - these could produce interesting results in this context", says Maria Kempe.

Guiding drug-loaded magnetic particles using a magnet outside the body is not a new idea. However, previous attempts have failed for various reasons: it has only been possible to reach the body's superficial tissue and the particles have often obstructed the smallest blood vessels.

The Lund researchers' attempt has succeeded partly because nanotechnology has made the particles tiny enough to pass through the smallest arteries and partly because the target has been a metallic stent. When the stent is placed in a magnetic field, the magnetic force becomes sufficiently strong to attract the magnetic nanoparticles. For the method to work the patient therefore has to have an implant containing a magnetic metal.

"It takes many years to develop a treatment method that can be used on patients. But the good initial results make us hopeful", says Maria Kempe.

Journal article

An article about the results, entitled ‘The use of magnetite nanoparticles for implant-assisted magnetic drug targeting in thrombolytic therapy', has recently been published in the journal Biomaterials. The article can be found on www.sciencedirect.com - enter Maria Kempe in the Author search field.

Moving picture

A 15 second clip (no sound) illustrating a blood vessel with a stent and nanoparticles passing by in the blood or being pulled to the stent by magnets.

Visit www.lu.se/upload/Englishsite/Magnetiska%20nanopartikar.avi

####

For more information, please click here

Contacts:
Maria Kempe
+46 (0)46 222 98 57
+46 (0)70 222 08 57

Copyright © Lund University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Basque researchers turn light upside down February 23rd, 2018

Stiffness matters February 23rd, 2018

Imaging individual flexible DNA 'building blocks' in 3-D: Berkeley Lab researchers generate first images of 129 DNA structures February 22nd, 2018

'Memtransistor' brings world closer to brain-like computing: Combined memristor and transistor can process information and store memory with one device February 22nd, 2018

Possible Futures

Basque researchers turn light upside down February 23rd, 2018

Stiffness matters February 23rd, 2018

Developing reliable quantum computers February 22nd, 2018

Imaging individual flexible DNA 'building blocks' in 3-D: Berkeley Lab researchers generate first images of 129 DNA structures February 22nd, 2018

Academic/Education

Luleå University of Technology is using the Deben CT5000TEC stage to perform x-ray microtomography experiments with the ZEISS Xradia 510 Versa to understand deformation and strain inside inhomogeneous materials November 7th, 2017

Park Systems Announces the Grand Opening of the Park NanoScience Center at SUNY Polytechnic Institute November 3rd, 2017

Two Scientists Receive Grants to Develop New Materials: Chad Mirkin and Monica Olvera de la Cruz recognized by Sherman Fairchild Foundation August 16th, 2017

Moving at the Speed of Light: University of Arizona selected for high-impact, industrial demonstration of new integrated photonic cryogenic datalink for focal plane arrays: Program is major milestone for AIM Photonics August 10th, 2017

Nanomedicine

Stiffness matters February 23rd, 2018

Histology in 3-D: New staining method enables Nano-CT imaging of tissue samples February 22nd, 2018

Imaging individual flexible DNA 'building blocks' in 3-D: Berkeley Lab researchers generate first images of 129 DNA structures February 22nd, 2018

Arrowhead Receives Regulatory Clearance to Begin Phase 1 Study of ARO-AAT for Treatment of Alpha-1 Liver Disease February 22nd, 2018

Announcements

Basque researchers turn light upside down February 23rd, 2018

Stiffness matters February 23rd, 2018

Histology in 3-D: New staining method enables Nano-CT imaging of tissue samples February 22nd, 2018

Developing reliable quantum computers February 22nd, 2018

Nanobiotechnology

Stiffness matters February 23rd, 2018

Histology in 3-D: New staining method enables Nano-CT imaging of tissue samples February 22nd, 2018

Imaging individual flexible DNA 'building blocks' in 3-D: Berkeley Lab researchers generate first images of 129 DNA structures February 22nd, 2018

Arrowhead Receives Regulatory Clearance to Begin Phase 1 Study of ARO-AAT for Treatment of Alpha-1 Liver Disease February 22nd, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project