Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Medicine reaches the target with the help of magnets

Professor Maria Kempe
Professor Maria Kempe

Abstract:
If a drug can be guided to the right place in the body, the treatment is more effective and there are fewer side-effects. Researchers at Lund University in Sweden have now developed magnetic nanoparticles that can be directed to metallic implants such as artificial knee joints, hip joints and stents in the coronary arteries.

Medicine reaches the target with the help of magnets

Sweden | Posted on August 26th, 2010

Associate Professor Maria Kempe, her brother and colleague Dr Henrik Kempe and members of staff at Skåne University Hospital have shown that the principle works in animal experiments.

They have succeeded in attaching a clot-dissolving drug to the nanoparticles and, with the help of magnets, have directed the particles to a blood clot in a stent in the heart to dissolve it. Thus the nanoparticles have been able to stop an incipient heart attack.

A stent is a tube-shaped metal net used to treat narrowing of the coronary arteries. First the artery is expanded using a balloon catheter, then a stent is inserted to keep the artery open. However, the method is not without problems: depending on the type of stent inserted, the cells of the artery wall can grow and again obstruct the artery or a blood clot can develop in the stent.

In the Lund researchers' experiments, the nanoparticles were coated with a drug used to treat blood clots. The particles could also carry other drugs, e.g. drugs to stop the cell growth that makes an artery become narrower.

"They could also carry antibiotics to treat an infection developed after insertion of an implant. We have developed polymer materials that can be loaded with antibiotics - these could produce interesting results in this context", says Maria Kempe.

Guiding drug-loaded magnetic particles using a magnet outside the body is not a new idea. However, previous attempts have failed for various reasons: it has only been possible to reach the body's superficial tissue and the particles have often obstructed the smallest blood vessels.

The Lund researchers' attempt has succeeded partly because nanotechnology has made the particles tiny enough to pass through the smallest arteries and partly because the target has been a metallic stent. When the stent is placed in a magnetic field, the magnetic force becomes sufficiently strong to attract the magnetic nanoparticles. For the method to work the patient therefore has to have an implant containing a magnetic metal.

"It takes many years to develop a treatment method that can be used on patients. But the good initial results make us hopeful", says Maria Kempe.

Journal article

An article about the results, entitled ‘The use of magnetite nanoparticles for implant-assisted magnetic drug targeting in thrombolytic therapy', has recently been published in the journal Biomaterials. The article can be found on www.sciencedirect.com - enter Maria Kempe in the Author search field.

Moving picture

A 15 second clip (no sound) illustrating a blood vessel with a stent and nanoparticles passing by in the blood or being pulled to the stent by magnets.

Visit www.lu.se/upload/Englishsite/Magnetiska%20nanopartikar.avi

####

For more information, please click here

Contacts:
Maria Kempe
+46 (0)46 222 98 57
+46 (0)70 222 08 57

Copyright © Lund University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Iranian Scientists Use Artemisia Annua Plant to Produce Breast Cancer Drugs August 29th, 2015

Small but heading for the big time: Nanobiotix half year results for the six months ended 30 June 2015, in line with expectations: Major clinical achievements and corporate developments August 28th, 2015

A new technique to make drugs more soluble August 28th, 2015

Nanocatalysts improve processes for the petrochemical industry August 28th, 2015

Possible Futures

Sediment dwelling creatures at risk from nanoparticles in common household products August 13th, 2015

Harris & Harris Group Reports Financial Statements as of June 30, 2015, and Announces a Stock Repurchase Program August 10th, 2015

Molecular trick alters rules of attraction for non-magnetic metals August 5th, 2015

Global Carbon Nanotubes Industry 2015: Acute Market Reports August 4th, 2015

Academic/Education

Announcing Oxford Instruments and School of Physics signing a Memorandum of Understanding August 26th, 2015

Kwansei Gakuin University in Hyogo, Japan, uses Raman microscopy to study crystallographic defects in silicon carbide wafers August 25th, 2015

JPK reports on the use of a NanoWizard® AFM-SECM system at the Université Paris Diderot looking at nanoscale biostructures August 18th, 2015

Rice, Penn State open center for 2-D coatings: National Science Foundation selects universities to develop atom-thin materials with industry partners August 13th, 2015

Nanomedicine

Iranian Scientists Use Artemisia Annua Plant to Produce Breast Cancer Drugs August 29th, 2015

Small but heading for the big time: Nanobiotix half year results for the six months ended 30 June 2015, in line with expectations: Major clinical achievements and corporate developments August 28th, 2015

A new technique to make drugs more soluble August 28th, 2015

These microscopic fish are 3-D-printed to do more than swim: Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities August 26th, 2015

Announcements

Iranian Scientists Use Artemisia Annua Plant to Produce Breast Cancer Drugs August 29th, 2015

Small but heading for the big time: Nanobiotix half year results for the six months ended 30 June 2015, in line with expectations: Major clinical achievements and corporate developments August 28th, 2015

A new technique to make drugs more soluble August 28th, 2015

Nanocatalysts improve processes for the petrochemical industry August 28th, 2015

Nanobiotechnology

Small but heading for the big time: Nanobiotix half year results for the six months ended 30 June 2015, in line with expectations: Major clinical achievements and corporate developments August 28th, 2015

Nanotechnology that will impact the Security & Defense sectors to be discussed at NanoSD2015 conference August 25th, 2015

Louisiana Tech University researchers discover synthesis of a new nanomaterial: Interdisciplinary team creates biocomposite for first time using physiological conditions August 24th, 2015

How UEA research could help build computers from DNA August 19th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic