Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Medicine reaches the target with the help of magnets

Professor Maria Kempe
Professor Maria Kempe

Abstract:
If a drug can be guided to the right place in the body, the treatment is more effective and there are fewer side-effects. Researchers at Lund University in Sweden have now developed magnetic nanoparticles that can be directed to metallic implants such as artificial knee joints, hip joints and stents in the coronary arteries.

Medicine reaches the target with the help of magnets

Sweden | Posted on August 26th, 2010

Associate Professor Maria Kempe, her brother and colleague Dr Henrik Kempe and members of staff at Skåne University Hospital have shown that the principle works in animal experiments.

They have succeeded in attaching a clot-dissolving drug to the nanoparticles and, with the help of magnets, have directed the particles to a blood clot in a stent in the heart to dissolve it. Thus the nanoparticles have been able to stop an incipient heart attack.

A stent is a tube-shaped metal net used to treat narrowing of the coronary arteries. First the artery is expanded using a balloon catheter, then a stent is inserted to keep the artery open. However, the method is not without problems: depending on the type of stent inserted, the cells of the artery wall can grow and again obstruct the artery or a blood clot can develop in the stent.

In the Lund researchers' experiments, the nanoparticles were coated with a drug used to treat blood clots. The particles could also carry other drugs, e.g. drugs to stop the cell growth that makes an artery become narrower.

"They could also carry antibiotics to treat an infection developed after insertion of an implant. We have developed polymer materials that can be loaded with antibiotics - these could produce interesting results in this context", says Maria Kempe.

Guiding drug-loaded magnetic particles using a magnet outside the body is not a new idea. However, previous attempts have failed for various reasons: it has only been possible to reach the body's superficial tissue and the particles have often obstructed the smallest blood vessels.

The Lund researchers' attempt has succeeded partly because nanotechnology has made the particles tiny enough to pass through the smallest arteries and partly because the target has been a metallic stent. When the stent is placed in a magnetic field, the magnetic force becomes sufficiently strong to attract the magnetic nanoparticles. For the method to work the patient therefore has to have an implant containing a magnetic metal.

"It takes many years to develop a treatment method that can be used on patients. But the good initial results make us hopeful", says Maria Kempe.

Journal article

An article about the results, entitled ‘The use of magnetite nanoparticles for implant-assisted magnetic drug targeting in thrombolytic therapy', has recently been published in the journal Biomaterials. The article can be found on www.sciencedirect.com - enter Maria Kempe in the Author search field.

Moving picture

A 15 second clip (no sound) illustrating a blood vessel with a stent and nanoparticles passing by in the blood or being pulled to the stent by magnets.

Visit www.lu.se/upload/Englishsite/Magnetiska%20nanopartikar.avi

####

For more information, please click here

Contacts:
Maria Kempe
+46 (0)46 222 98 57
+46 (0)70 222 08 57

Copyright © Lund University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Caught on camera -- chemical reactions 'filmed' at the single-molecule level March 22nd, 2017

Rare-earths become water-repellent only as they age March 22nd, 2017

Pulverizing e-waste is green, clean -- and cold: Rice, Indian Institute researchers use cryo-mill to turn circuit boards into separated powders March 21st, 2017

CRMGroup in Belgium uses a Deben three point bending stage in the development of new steel & coated steel products for automotive and other industrial applications March 21st, 2017

Possible Futures

Rare-earths become water-repellent only as they age March 22nd, 2017

Pulverizing e-waste is green, clean -- and cold: Rice, Indian Institute researchers use cryo-mill to turn circuit boards into separated powders March 21st, 2017

Electro-optical switch transmits data at record-low temperatures: Operating at temperatures near absolute zero, switch could enable significantly faster data processing with lower power consumption March 20th, 2017

Nanoparticle paves the way for new triple negative breast cancer drug March 20th, 2017

Academic/Education

AIM Photonics Welcomes Coventor as Newest Member: US-Backed Initiative Taps Process Modeling Specialist to Enable Manufacturing of High-Yield, High-Performance Integrated Photonic Designs March 16th, 2017

Nominations Invited for $250,000 Kabiller Prize in Nanoscience: Major international prize recognizes a visionary nanotechnology researcher February 20th, 2017

Oxford Nanoimaging report on how the Nanoimager, a desktop microscope delivering single molecule, super-resolution performance, is being applied at the MRC Centre for Molecular Bacteriology & Infection November 22nd, 2016

The University of Applied Sciences in Upper Austria uses Deben tensile stages as an integral part of their computed tomography research and testing facility October 18th, 2016

Nanomedicine

Nanoparticle paves the way for new triple negative breast cancer drug March 20th, 2017

Block copolymer micellization as a protection strategy for DNA origami March 17th, 2017

Nanocages for gold particles: what is happening inside? March 16th, 2017

Biophysicists propose new approach for membrane protein crystallization March 8th, 2017

Announcements

Caught on camera -- chemical reactions 'filmed' at the single-molecule level March 22nd, 2017

Rare-earths become water-repellent only as they age March 22nd, 2017

Pulverizing e-waste is green, clean -- and cold: Rice, Indian Institute researchers use cryo-mill to turn circuit boards into separated powders March 21st, 2017

CRMGroup in Belgium uses a Deben three point bending stage in the development of new steel & coated steel products for automotive and other industrial applications March 21st, 2017

Nanobiotechnology

Nanoparticle paves the way for new triple negative breast cancer drug March 20th, 2017

Block copolymer micellization as a protection strategy for DNA origami March 17th, 2017

Nanocages for gold particles: what is happening inside? March 16th, 2017

Biophysicists propose new approach for membrane protein crystallization March 8th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project