Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Microneedle, Quantum Dot Study Opens Door To New Clinical Cancer Tools

Hollow microneedles open the door to new techniques for diagnosing and treating a variety of medical conditions, including skin cancer. Image reproduced by permission of the Royal Society of Chemistry.
Hollow microneedles open the door to new techniques for diagnosing and treating a variety of medical conditions, including skin cancer. Image reproduced by permission of the Royal Society of Chemistry.

Abstract:
Researchers from North Carolina State University have developed extremely small microneedles that can be used to deliver medically-relevant nanoscale dyes called quantum dots into skin - an advance that opens the door to new techniques for diagnosing and treating a variety of medical conditions, including skin cancer.

Microneedle, Quantum Dot Study Opens Door To New Clinical Cancer Tools

Raleigh, NC | Posted on August 25th, 2010

"We were able to fabricate hollow, plastic microneedles using a laser-based rapid-prototyping approach," says Dr. Roger Narayan, one of the lead researchers, "and found that we could deliver a solution containing quantum dots using these microneedles." Microneedles are very small needles in which at least one dimension - such as length - is less than one millimeter. Narayan is a professor in the joint biomedical engineering department of NC State's College of Engineering and the University of North Carolina at Chapel Hill.

"The motivation for the study was to see whether we could use microneedles to deliver quantum dots into the skin," Narayan says. "Our findings are significant, in part, because this technology will potentially enable researchers to deliver quantum dots, suspended in solution, to deeper layers of skin. That could be useful for the diagnosis and treatment of skin cancers, among other conditions." Quantum dots are nanoscale crystals with unique properties in terms of light emission. They hold promise as a tool in medical diagnosis.The researchers created the plastic microneedles and tested them using pig skin, which has characteristics closely resembling human skin. Using a water-based solution containing quantum dots, the researchers were able to capture images of the quantum dots entering the skin using multiphoton microscopy. These images show the mechanism by which the quantum dots enter the layers of skin, allowing the researchers to verify the effectiveness of the microneedles as a delivery mechanism for quantum dots.

The imaging method used in this study, multiphoton microscopy, may have clinical applications for real-time imaging of dyes - such as quantum dots - in the skin. This could contribute to more rapid diagnosis of cancers or other medical problems.

The study is also significant because it shows that a laser-based rapid prototyping approach allows for the creation of microneedles of varying lengths and shapes. This will allow physicians to create microneedles that are customized for treatment of a specific condition.

Specifically, the microneedles were created using two-photon polymerization, an approach pioneered by NC State and Laser Zentrum Hannover for use in medical device applications. Two-photon polymerization allowed the researchers to create hollow, plastic microneedles with specific design characteristics. "Our use of this fabrication technology highlights its potential for other small-scale medical device applications," Narayan says.

A paper describing the study, "Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles," will be published in the September issue of Faraday Discussions. The work was funded by the National Science Foundation and the National Institutes of Health.

The research was co-authored by Dr. Nancy Monteiro-Riviere, professor of investigative dermatology and toxicology at NC State's Center for Chemical Toxicology Research and Pharmacokinetics; NC State Ph.D. students Shaun Gittard, Philip Miller and Ryan Boehm; Drs. Aleksandr Ovsianikov and Boris Chichkov of Laser Zentrum Hannover; and researchers from Ceramatec Inc. and MicroLin LLC & Technology Holding LLC.

Abstract

"Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles"

Authors: Shaun D. Gittard, Philip R. Miller, Ryan D. Boehm, Nancy A. Monteiro-Riviere, Roger J. Narayan, North Carolina State University; Boris Chichkov, Aleksandr Ovsianikov, Laser Zentrum Hannover; Jeremy Heiser, John Gordon, Ceramatec Inc. and MicroLin LLC & Technology Holding LLC

Published: September 2010, Faraday Discussions

Abstract: Due to their ability to serve as fluorophores and drug delivery vehicles, quantum dots are a powerful tool for theranostics-based clinical applications. In this study, microneedle devices for transdermal drug delivery were fabricated by means of two-photon polymerization of an acrylate-based polymer. We examined proliferation of cells on this polymer using neonatal human epidermal keratinocytes and human dermal fibroblasts. The microneedle device was used to inject quantum dots into porcine skin; imaging of the quantum dots was performed using multiphoton microscopy.

####

For more information, please click here

Contacts:
Matt Shipman
News Services
919.515.6386

Dr. Roger Narayan
919.696.8488

Copyright © North Carolina State University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Journal Nanotechnology Progress International (JONPI) Volume 6, issue 2 coming out soon! December 5th, 2016

Infrared instrumentation leader secures exclusive use of Vantablack coating December 5th, 2016

Construction of practical quantum computers radically simplified: Scientists invent ground-breaking new method that puts quantum computers within reach December 5th, 2016

Possible Futures

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Construction of practical quantum computers radically simplified: Scientists invent ground-breaking new method that puts quantum computers within reach December 5th, 2016

Shape matters when light meets atom: Mapping the interaction of a single atom with a single photon may inform design of quantum devices December 4th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Academic/Education

Oxford Nanoimaging report on how the Nanoimager, a desktop microscope delivering single molecule, super-resolution performance, is being applied at the MRC Centre for Molecular Bacteriology & Infection November 22nd, 2016

The University of Applied Sciences in Upper Austria uses Deben tensile stages as an integral part of their computed tomography research and testing facility October 18th, 2016

Enterprise In Space Partners with Sketchfab and 3D Hubs for NewSpace Education October 13th, 2016

New Agricultural Research Center Debuts at UCF October 12th, 2016

Nanomedicine

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Journal Nanotechnology Progress International (JONPI) Volume 6, issue 2 coming out soon! December 5th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

Announcements

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Journal Nanotechnology Progress International (JONPI) Volume 6, issue 2 coming out soon! December 5th, 2016

Infrared instrumentation leader secures exclusive use of Vantablack coating December 5th, 2016

Construction of practical quantum computers radically simplified: Scientists invent ground-breaking new method that puts quantum computers within reach December 5th, 2016

Quantum Dots/Rods

Trickling electrons: Close to absolute zero, the particles exhibit their quantum nature November 10th, 2016

Notre Dame researchers find transition point in semiconductor nanomaterials September 6th, 2016

Quantum dots with impermeable shell: A powerful tool for nanoengineering August 12th, 2016

Diamond-based light sources will lay a foundation for quantum communications of the future: Electrified quantum diamond can become the heart of quantum networks and computers of the future August 7th, 2016

Nanobiotechnology

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

From champagne bubbles, dance parties and disease to new nanomaterials: Understanding nucleation of protein filaments might help with Alzheimer's Disease and type 2 Diabetes November 24th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project