Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanosensors Detect Signs of Cancer in Human Breath

Abstract:
With a single breath, a Breathalyzer™ can tell a police officer when a driver has had too much to drink. Now, thanks to a team of investigators at the Israel Institute of Technology, a single breath may be enough to tell a doctor that their patient has cancer.

Nanosensors Detect Signs of Cancer in Human Breath

Bethesda, MD | Posted on August 18th, 2010

Reporting its work in the British Journal of Cancer, a research team headed by Hossam Haick demonstrated that a nanosensor array made of gold nanoparticles can differentiate between healthy patients and those with lung, breast, colorectal, and prostate cancers based on a single exhaled breath. The nanosensor array detects trace chemical known as volatile organic compounds (VOCs) that are generated by cancer cells, escape into the blood stream, and then released along with carbon dioxide into the lungs, from which they are exhaled. In addition, the investigators found that patients with each of the four cancers had characteristic VOC profiles, though these differences were not well-differentiated enough to diagnose a specific form of cancer.

To test their device, the researchers collected exhaled breaths from 177 volunteers, 96 of whom had just been diagnosed with lung, breast, colorectal, or prostate cancer and had not yet received therapy. Each test subject spent up to five minutes breathing purified air before exhaling into a collection bag; this was to ensure that any VOCs detected in the subjects' breaths did not originate in the ambient air that they were breathing. The researchers used collection bags made of chemically inert Mylar so that the bags could be reused after thorough cleaning with ultrapure nitrogen gas.

After testing the samples using their nanosensor array, the investigators repeated their analysis using gas chromatography-mass spectrometry (GC-MS), a highly accurate analytical method that would be too slow and costly to use in any routine diagnostic procedure. GC-MS also requires the use of a pre-concentration step in order to detect the low levels of VOCs in human breath. Comparison of the results obtained using the two techniques showed that the nanosensor arrays was the more accurate of the two methods as far as discriminating between healthy patients and those with cancer, and in distinguishing one type of cancer from another. More importantly, results from the nanosensor array - unlike those obtained using GC-MS - were not dependent on the gender, age, ethnic origin, family cancer history, intake of food additives, drug treatment, exposure to environmental toxins, and smoking habits.

This work is detailed in a paper titled, "Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors." An abstract of this paper is available at the journal's Web site.

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

A nanoscale wireless communication system via plasmonic antennas: Greater control affords 'in-plane' transmission of waves at or near visible light August 27th, 2016

Forces of nature: Interview with microscopy innovators Gerd Binnig and Christoph Gerber August 26th, 2016

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Graphene under pressure August 26th, 2016

Possible Futures

A nanoscale wireless communication system via plasmonic antennas: Greater control affords 'in-plane' transmission of waves at or near visible light August 27th, 2016

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Graphene under pressure August 26th, 2016

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

Academic/Education

AIM Photonics Announces Release of Process Design Kit (PDK) for Integrated Silicon Photonics Design August 25th, 2016

Nanotech Security Featured by Simon Fraser University: Company's Anti-Counterfeiting Technology Developed With the Help of University's 4D LABS Materials Research Institute August 21st, 2016

W.M. Keck Foundation awards Cal State LA a $375,000 research and education grant August 4th, 2016

Thomas Swan and NGI announce unique partnership July 28th, 2016

Nanomedicine

Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

50 years after the release of the film 'Fantastic Voyage,' science upstages fiction: Science upstages fiction with nanorobotic agents designed to travel in the human body to treat cancer August 25th, 2016

Tunneling nanotubes between neurons enable the spread of Parkinson's disease via lysosomes August 24th, 2016

Sensors

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Down to the wire: ONR researchers and new bacteria August 18th, 2016

'Sniffer plasmons' could detect explosives: Scientists have proposed a graphene-based spaser that can detect even small amounts of various substances, including explosives August 16th, 2016

Perpetual 'ice water': Stable solid-liquid state revealed in nanoparticles: Gallium nanoparticles that are both solid and liquid are stable over a range of 1000 degrees Fahrenheit August 5th, 2016

Announcements

A nanoscale wireless communication system via plasmonic antennas: Greater control affords 'in-plane' transmission of waves at or near visible light August 27th, 2016

Forces of nature: Interview with microscopy innovators Gerd Binnig and Christoph Gerber August 26th, 2016

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Graphene under pressure August 26th, 2016

Nanobiotechnology

Analog DNA circuit does math in a test tube: DNA computers could one day be programmed to diagnose and treat disease August 25th, 2016

Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

50 years after the release of the film 'Fantastic Voyage,' science upstages fiction: Science upstages fiction with nanorobotic agents designed to travel in the human body to treat cancer August 25th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic