Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanosensors Detect Signs of Cancer in Human Breath

Abstract:
With a single breath, a Breathalyzer™ can tell a police officer when a driver has had too much to drink. Now, thanks to a team of investigators at the Israel Institute of Technology, a single breath may be enough to tell a doctor that their patient has cancer.

Nanosensors Detect Signs of Cancer in Human Breath

Bethesda, MD | Posted on August 18th, 2010

Reporting its work in the British Journal of Cancer, a research team headed by Hossam Haick demonstrated that a nanosensor array made of gold nanoparticles can differentiate between healthy patients and those with lung, breast, colorectal, and prostate cancers based on a single exhaled breath. The nanosensor array detects trace chemical known as volatile organic compounds (VOCs) that are generated by cancer cells, escape into the blood stream, and then released along with carbon dioxide into the lungs, from which they are exhaled. In addition, the investigators found that patients with each of the four cancers had characteristic VOC profiles, though these differences were not well-differentiated enough to diagnose a specific form of cancer.

To test their device, the researchers collected exhaled breaths from 177 volunteers, 96 of whom had just been diagnosed with lung, breast, colorectal, or prostate cancer and had not yet received therapy. Each test subject spent up to five minutes breathing purified air before exhaling into a collection bag; this was to ensure that any VOCs detected in the subjects' breaths did not originate in the ambient air that they were breathing. The researchers used collection bags made of chemically inert Mylar so that the bags could be reused after thorough cleaning with ultrapure nitrogen gas.

After testing the samples using their nanosensor array, the investigators repeated their analysis using gas chromatography-mass spectrometry (GC-MS), a highly accurate analytical method that would be too slow and costly to use in any routine diagnostic procedure. GC-MS also requires the use of a pre-concentration step in order to detect the low levels of VOCs in human breath. Comparison of the results obtained using the two techniques showed that the nanosensor arrays was the more accurate of the two methods as far as discriminating between healthy patients and those with cancer, and in distinguishing one type of cancer from another. More importantly, results from the nanosensor array - unlike those obtained using GC-MS - were not dependent on the gender, age, ethnic origin, family cancer history, intake of food additives, drug treatment, exposure to environmental toxins, and smoking habits.

This work is detailed in a paper titled, "Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors." An abstract of this paper is available at the journal's Web site.

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

National Space Society Congratulates SpaceX on the Falcon 9's Return to Flight January 19th, 2017

Eric Berger Wins the National Space Society's 2017 Space Pioneer Award for Mass Media January 19th, 2017

Nanometrics to Announce Fourth Quarter and Full Year Financial Results on February 7, 2017 January 19th, 2017

Possible Futures

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

National Space Society Congratulates SpaceX on the Falcon 9's Return to Flight January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

Strength of hair inspires new materials for body armor January 18th, 2017

Academic/Education

Oxford Nanoimaging report on how the Nanoimager, a desktop microscope delivering single molecule, super-resolution performance, is being applied at the MRC Centre for Molecular Bacteriology & Infection November 22nd, 2016

The University of Applied Sciences in Upper Austria uses Deben tensile stages as an integral part of their computed tomography research and testing facility October 18th, 2016

Enterprise In Space Partners with Sketchfab and 3D Hubs for NewSpace Education October 13th, 2016

New Agricultural Research Center Debuts at UCF October 12th, 2016

Nanomedicine

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

New active filaments mimic biology to transport nano-cargo: A new design for a fully biocompatible motility engine transports colloidal particles faster than diffusion with active filaments January 11th, 2017

Keystone Nano Announces FDA Approval Of Investigational New Drug Application For Ceramide NanoLiposome For The Improved Treatment Of Cancer January 10th, 2017

Sensors

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

Nanoscale Modifications can be used to Engineer Electrical Contacts for Nanodevices January 13th, 2017

Researchers create practical and versatile microscopic optomechanical device: Trapping light and mechanical waves within a tiny bullseye, design could enable more sensitive motion detection January 11th, 2017

STMicroelectronics Peps Up Booming Social-Fitness Scene with Smart Motion Sensors for Better Accuracy, Longer Battery Life, and Faster Time to Market January 2nd, 2017

Announcements

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

National Space Society Congratulates SpaceX on the Falcon 9's Return to Flight January 19th, 2017

Eric Berger Wins the National Space Society's 2017 Space Pioneer Award for Mass Media January 19th, 2017

Nanometrics to Announce Fourth Quarter and Full Year Financial Results on February 7, 2017 January 19th, 2017

Nanobiotechnology

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

Nanoscale Modifications can be used to Engineer Electrical Contacts for Nanodevices January 13th, 2017

New active filaments mimic biology to transport nano-cargo: A new design for a fully biocompatible motility engine transports colloidal particles faster than diffusion with active filaments January 11th, 2017

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project