Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > NSF Funds Innovative Approach to Biomimetic Nanofiber Bone Regeneration

Abstract:
Every year nearly 6.2 million bone fractures occur in the United States as a result of trauma and disease. Current standards for bone repair can lead to rapid bone fusion but with limited mechanical strength often due to the lack of cortical bone tissue which is difficult to harvest without pain and severe morbidity. Funded by the National Science Foundation, Dr. Hongjun Wang, a professor in the Department of Chemistry, Chemical Biology and Biomedical Engineering at Stevens Institute of Technology and his collaborators have developed a revolutionary "bottom-up" approach for reconstructing intricate bone tissue with the potential to form hierarchical cortical bone.

NSF Funds Innovative Approach to Biomimetic Nanofiber Bone Regeneration

Hoboken, NJ | Posted on August 8th, 2010

Dr. Wang's research project, "Biomimetic Creation of Cortical-like Bone with Hierarchical Structure," will develop robust, controllable and effective platforms for the creation of tissues with complex and hierarchical structure for potential applications in reconstructive and transplant surgery.

Biomimetics is the study and development of synthetic systems that mimic the formation, function, or structure of biologically produced substances, materials, mechanisms and processes. Wang's research team is part of a thriving tissue engineering industry that uses a combination of cells, engineering and materials methods, and suitable biochemical and physio-chemical factors to repair or replace portions of damaged tissues.

In contrast to current state-of-the-art research that focuses on creating highly porous cancellous bone, Dr. Wang focuses on engineering cortical bone, the major load bearing component. He takes a modular approach to generating dense cortical bone by synthesizing osteon-like repeating units and fusing these units together to form large, compacted cortical-like bone tissue. This "bottom-up" methodology uses nanotechnology to enable the development of scaffolds that focus on the smallest level possible and build upward. Incorporating nanofibers into bone tissue engineering to form the small cortical bone repeating units, these biomimetic scaffolds offer large surface areas and well-interconnected pores for nutrient transport and cell penetration, and more importantly, provide a biomimetic cell-friendly microenvironment to facilitate the bone tissue formation, needed for successful repair of large bone defects.

"The results of Dr. Wang's research will have a far-reaching impact on tissue engineering," says Dr. Michael Bruno, Dean of the Schaefer School of Engineering and Science. "The wealth of basic and applied knowledge learned at Stevens will lay the foundation for our long-term research efforts and the development of real-world applications."

Over the next-three years, Dr. Wang's research team plan to make substantial strides in synergistically integrating nanobiomaterials with bone tissue engineering for the creation of cortical bone with hierarchical structure and functional complexity.

"We hope to establish a family of biomimetic nanofibers containing collagen and calcium phosphate to support the phenotype of bone-forming cells; new practical approaches to creating osteon-like units using biomimetic nanofibers and osteoblasts; formulation of calcium phosphate containing collagen gel for bone tissue formation; and most importantly, an innovative approach to generating cortical-like bone by assembling osteon-like structures into one fused construct," explains Dr. Wang.

"The intellectually rich environment established by Dr. Wang and his team is inspiring to our graduate and undergraduate students who are participating in the transformative benefits of cutting-edge research and its profound application," says Dr. Philip Leopold, Director of the Department of Chemistry, Chemical Biology and Biomedical Engineering.

For more information on Stevens Pioneering Bone Regeneration research, please contact Dr. Wang:

www.stevens.edu/research/research_profile.php?fac_id=16

####

About Stevens Institute of Technology
Founded in 1870 and celebrating 140 Years of Innovation, Stevens Institute of Technology, The Innovation University TM , lives at the intersection of industry, academics and research. The University's students, faculty and partners leverage their collective real-world experience and culture of innovation, research and entrepreneurship to confront global challenges in engineering, science, systems and technology management.

Based in Hoboken, N.J. and with a location in Washington, D.C., Stevens offers baccalaureate, masterís, certificates and doctoral degrees in engineering, the sciences and management, in addition to baccalaureate degrees in business and liberal arts. Stevens has been recognized by both the US Department of Defense and the Department of Homeland Security as a National Center of Excellence in the areas of systems engineering and port security research. The University has a total enrollment of more than 2,200 undergraduate and 3,700 graduate students with almost 450 faculty. Stevensí graduate programs have attracted international participation from China, India, Southeast Asia, Europe and Latin America as well as strategic partnerships with industry leaders, governments and other universities around the world. Additional information may be obtained at www.stevens.edu and www.stevens.edu/press.

For more information, please click here

Contacts:
Office of University Communications
+1-201-216-5116

Copyright © Stevens Institute of Technology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Explaining how 2-D materials break at the atomic level January 20th, 2017

New research helps to meet the challenges of nanotechnology: Research helps to make the most of nanoscale catalytic effects for nanotechnology January 20th, 2017

Ultra-precise chip-scale sensor detects unprecedentedly small changes at the nanoscale January 20th, 2017

Nanometrics to Announce Fourth Quarter and Full Year Financial Results on February 7, 2017 January 19th, 2017

Govt.-Legislation/Regulation/Funding/Policy

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

Strength of hair inspires new materials for body armor January 18th, 2017

Self-assembling particles brighten future of LED lighting January 18th, 2017

Nanoscale view of energy storage January 16th, 2017

Possible Futures

Explaining how 2-D materials break at the atomic level January 20th, 2017

New research helps to meet the challenges of nanotechnology: Research helps to make the most of nanoscale catalytic effects for nanotechnology January 20th, 2017

Ultra-precise chip-scale sensor detects unprecedentedly small changes at the nanoscale January 20th, 2017

National Space Society Congratulates SpaceX on the Falcon 9's Return to Flight January 19th, 2017

Academic/Education

Oxford Nanoimaging report on how the Nanoimager, a desktop microscope delivering single molecule, super-resolution performance, is being applied at the MRC Centre for Molecular Bacteriology & Infection November 22nd, 2016

The University of Applied Sciences in Upper Austria uses Deben tensile stages as an integral part of their computed tomography research and testing facility October 18th, 2016

Enterprise In Space Partners with Sketchfab and 3D Hubs for NewSpace Education October 13th, 2016

New Agricultural Research Center Debuts at UCF October 12th, 2016

Nanomedicine

New research helps to meet the challenges of nanotechnology: Research helps to make the most of nanoscale catalytic effects for nanotechnology January 20th, 2017

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

New active filaments mimic biology to transport nano-cargo: A new design for a fully biocompatible motility engine transports colloidal particles faster than diffusion with active filaments January 11th, 2017

Announcements

New research helps to meet the challenges of nanotechnology: Research helps to make the most of nanoscale catalytic effects for nanotechnology January 20th, 2017

Ultra-precise chip-scale sensor detects unprecedentedly small changes at the nanoscale January 20th, 2017

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

National Space Society Congratulates SpaceX on the Falcon 9's Return to Flight January 19th, 2017

Nanobiotechnology

New research helps to meet the challenges of nanotechnology: Research helps to make the most of nanoscale catalytic effects for nanotechnology January 20th, 2017

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

Nanoscale Modifications can be used to Engineer Electrical Contacts for Nanodevices January 13th, 2017

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project