Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > NSF Funds Innovative Approach to Biomimetic Nanofiber Bone Regeneration

Abstract:
Every year nearly 6.2 million bone fractures occur in the United States as a result of trauma and disease. Current standards for bone repair can lead to rapid bone fusion but with limited mechanical strength often due to the lack of cortical bone tissue which is difficult to harvest without pain and severe morbidity. Funded by the National Science Foundation, Dr. Hongjun Wang, a professor in the Department of Chemistry, Chemical Biology and Biomedical Engineering at Stevens Institute of Technology and his collaborators have developed a revolutionary "bottom-up" approach for reconstructing intricate bone tissue with the potential to form hierarchical cortical bone.

NSF Funds Innovative Approach to Biomimetic Nanofiber Bone Regeneration

Hoboken, NJ | Posted on August 8th, 2010

Dr. Wang's research project, "Biomimetic Creation of Cortical-like Bone with Hierarchical Structure," will develop robust, controllable and effective platforms for the creation of tissues with complex and hierarchical structure for potential applications in reconstructive and transplant surgery.

Biomimetics is the study and development of synthetic systems that mimic the formation, function, or structure of biologically produced substances, materials, mechanisms and processes. Wang's research team is part of a thriving tissue engineering industry that uses a combination of cells, engineering and materials methods, and suitable biochemical and physio-chemical factors to repair or replace portions of damaged tissues.

In contrast to current state-of-the-art research that focuses on creating highly porous cancellous bone, Dr. Wang focuses on engineering cortical bone, the major load bearing component. He takes a modular approach to generating dense cortical bone by synthesizing osteon-like repeating units and fusing these units together to form large, compacted cortical-like bone tissue. This "bottom-up" methodology uses nanotechnology to enable the development of scaffolds that focus on the smallest level possible and build upward. Incorporating nanofibers into bone tissue engineering to form the small cortical bone repeating units, these biomimetic scaffolds offer large surface areas and well-interconnected pores for nutrient transport and cell penetration, and more importantly, provide a biomimetic cell-friendly microenvironment to facilitate the bone tissue formation, needed for successful repair of large bone defects.

"The results of Dr. Wang's research will have a far-reaching impact on tissue engineering," says Dr. Michael Bruno, Dean of the Schaefer School of Engineering and Science. "The wealth of basic and applied knowledge learned at Stevens will lay the foundation for our long-term research efforts and the development of real-world applications."

Over the next-three years, Dr. Wang's research team plan to make substantial strides in synergistically integrating nanobiomaterials with bone tissue engineering for the creation of cortical bone with hierarchical structure and functional complexity.

"We hope to establish a family of biomimetic nanofibers containing collagen and calcium phosphate to support the phenotype of bone-forming cells; new practical approaches to creating osteon-like units using biomimetic nanofibers and osteoblasts; formulation of calcium phosphate containing collagen gel for bone tissue formation; and most importantly, an innovative approach to generating cortical-like bone by assembling osteon-like structures into one fused construct," explains Dr. Wang.

"The intellectually rich environment established by Dr. Wang and his team is inspiring to our graduate and undergraduate students who are participating in the transformative benefits of cutting-edge research and its profound application," says Dr. Philip Leopold, Director of the Department of Chemistry, Chemical Biology and Biomedical Engineering.

For more information on Stevens Pioneering Bone Regeneration research, please contact Dr. Wang:

www.stevens.edu/research/research_profile.php?fac_id=16

####

About Stevens Institute of Technology
Founded in 1870 and celebrating 140 Years of Innovation, Stevens Institute of Technology, The Innovation University TM , lives at the intersection of industry, academics and research. The University's students, faculty and partners leverage their collective real-world experience and culture of innovation, research and entrepreneurship to confront global challenges in engineering, science, systems and technology management.

Based in Hoboken, N.J. and with a location in Washington, D.C., Stevens offers baccalaureate, master’s, certificates and doctoral degrees in engineering, the sciences and management, in addition to baccalaureate degrees in business and liberal arts. Stevens has been recognized by both the US Department of Defense and the Department of Homeland Security as a National Center of Excellence in the areas of systems engineering and port security research. The University has a total enrollment of more than 2,200 undergraduate and 3,700 graduate students with almost 450 faculty. Stevens’ graduate programs have attracted international participation from China, India, Southeast Asia, Europe and Latin America as well as strategic partnerships with industry leaders, governments and other universities around the world. Additional information may be obtained at www.stevens.edu and www.stevens.edu/press.

For more information, please click here

Contacts:
Office of University Communications
+1-201-216-5116

Copyright © Stevens Institute of Technology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

High-temperature plasmonics eyed for solar, computer innovation April 17th, 2014

INSCX™ exchange to present Exchange trade reporting mechanism for engineered nanomaterials (NMs) to UK regulation agencies, insurers and upstream/downstream users April 17th, 2014

Transparent Conductive Films and Sensors Are Hot Segments in Printed Electronics: Start-ups in these fields show above-average momentum, while companies working on emissive displays such as OLED are fading, Lux Research says April 17th, 2014

Harris & Harris Group Continues Its Blog Series to Highlight Most Impactful Portfolio Companies With Champions Oncology, Inc. April 17th, 2014

Govt.-Legislation/Regulation/Funding/Policy

INSCX™ exchange to present Exchange trade reporting mechanism for engineered nanomaterials (NMs) to UK regulation agencies, insurers and upstream/downstream users April 17th, 2014

ECHA Planning Workshop on Regulatory Challenges in the Risk Assessment of Nanomaterials April 16th, 2014

UT Arlington physicist creates new nanoparticle for cancer therapy April 16th, 2014

Relieving electric vehicle range anxiety with improved batteries: Lithium-sulfur batteries last longer with nanomaterial-packed cathode April 16th, 2014

Possible Futures

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014

Surface Characteristics Influence Cellular Growth on Semiconductor Material March 12th, 2014

The "Tipping Point" February 12th, 2014

Academic/Education

Director Wally Pfister joins UC Berkeley neuroengineers to discuss the science behind ‘Transcendence’ April 7th, 2014

First annual science week highlights STEM pipeline and partnerships: UB, SUNY Buffalo State and ECC team up with the City of Buffalo and its schools for April 7-11 events April 3rd, 2014

Global 450 consortium announces new general manager of internal operations: TSMC’s Cheng-Chung Chien Receives Unanimous Support, Brings History of Innovation and Efficiency to Global Consortium of Companies Driving Industry Transition to 450mm Wafer Technology March 26th, 2014

NanoTecNexus to Host "Chemistry of Wine" Fundraiser in Support of STEM Education - Collaborations Key to Success - March 20th, 2014

Nanomedicine

High-temperature plasmonics eyed for solar, computer innovation April 17th, 2014

Harris & Harris Group Continues Its Blog Series to Highlight Most Impactful Portfolio Companies With Champions Oncology, Inc. April 17th, 2014

UT Arlington physicist creates new nanoparticle for cancer therapy April 16th, 2014

Nanobiotix Appoints Thierry Otin as Head of Manufacturing and Supply April 15th, 2014

Announcements

High-temperature plasmonics eyed for solar, computer innovation April 17th, 2014

INSCX™ exchange to present Exchange trade reporting mechanism for engineered nanomaterials (NMs) to UK regulation agencies, insurers and upstream/downstream users April 17th, 2014

Transparent Conductive Films and Sensors Are Hot Segments in Printed Electronics: Start-ups in these fields show above-average momentum, while companies working on emissive displays such as OLED are fading, Lux Research says April 17th, 2014

Harris & Harris Group Continues Its Blog Series to Highlight Most Impactful Portfolio Companies With Champions Oncology, Inc. April 17th, 2014

Nanobiotechnology

Targeting cancer with a triple threat: MIT chemists design nanoparticles that can deliver three cancer drugs at a time April 15th, 2014

Biologists Develop Nanosensors to Visualize Movements and Distribution of Plant Stress Hormone April 15th, 2014

In latest generation of tiny biosensors, size isn't everything: UCLA researchers overturn conventional wisdom on nanowire-based diagnostic devices April 11th, 2014

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE