Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanofibers Help Scientists Study Brain Cancer In The Lab

Abstract:
Cancer and engineering scientists at The Ohio State University are collaborating to create molecule-sized nanofibers to mimic the structure of white matter in the brain. By combining nanotechnology with a medically-approved polymer, researchers are able to study the invasive behavior of tumor cells.

Nanofibers Help Scientists Study Brain Cancer In The Lab

Columbus, OH | Posted on August 3rd, 2010

The nanofibers are used to produce a more natural, three-dimensional environment for studying cancer cells outside the brain, and for testing potential drugs to treat this deadly disease.

Malignant brain tumor cells often migrate into surrounding healthy brain tissue, making these tumors extremely difficult or impossible to cure even after surgery, radiation and chemotherapy. These highly migratory cells follow fibrous tracks that are part of the brain's neural topography. Migratory cells resist clinical treatments and often produce a fatal tumor recurrence.

Mariano Viapiano, a researcher at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) is collaborating with John Lannutti, professor of materials science and engineering in Ohio State's College of Engineering, and others, to develop biologically compatible nanofibers that mimic the neural topography used by migratory tumor cells.

"We were trying to improve our understanding of how cancer invades in the brain and other organs," says Viapiano, a member of the Center for Molecular Neurobiology and the Molecular Biology and Cancer Genetics Research Program at OSUCCC-James. "We have found the behavior of tumor cells is much more similar to the behavior in the real tumor when we grow them on these nanofibers instead of conventional, rigid plastic petri dishes."

The nanofibers are so small that their general structure can only be observed in a scanning electron microscope. For perspective, it would take nearly 100 nanofibers side-by-side to equal the width of one human hair.

For generations, scientists have used petri dishes to grow living cells in the laboratory. But the cancer cells they observed and treated in this two-dimensional environment behaved much differently than they did in three-dimensional human tissue.

In contrast, nanofibers form spider web-like three-dimensional cell cultures in which cancer cells move and climb much as they do in human tissue.

"We want to analyze cells behaving in a manner more representative to how they behave in patients," said Viapiano, who is an assistant professor of neurological surgery in the College of Medicine. "This is a significant improvement because it is giving us a new environment to culture the cells."

####

About Ohio State University Comprehensive Cancer Center
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (cancer.osu.edu) is one of only 40 Comprehensive Cancer Centers in the United States designated by the National Cancer Institute. Ranked by U.S. News & World Report among the top cancer hospitals in the nation, The James is the 180-bed adult patient-care component of the cancer program at The Ohio State University. The OSUCCC-James is one of only seven funded programs in the country approved by the NCI to conduct both Phase I and Phase II clinical trials.

For more information, please click here

Contacts:
Eileen Scahill
Medical Center Public Affairs and Media Relations
614-293-3737

Copyright © Ohio State University Comprehensive Cancer Center

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

PETA science consortium to present hazard testing strategy at nanotoxicology meeting: High tech field ripe for use of sophisticated non-animal testing strategies April 22nd, 2014

Harris & Harris Group Notes the Receipt of Proceeds From the Sale of Molecular Imprints' Semiconductor Business to Canon April 22nd, 2014

National Space Society Congratulates SpaceX on the Success of CRS-3 and the First Flight of the Falcon 9R April 22nd, 2014

Academic/Education

Global leader in solar cell manufacturing eyes New York for major expansion outside of Japan: CNSE and Solar Frontier Explore $700 Million Investment, Job Creation in New York State April 22nd, 2014

University of Waterloo Visits China to Strengthen Bonds With Research Partners April 21st, 2014

Director Wally Pfister joins UC Berkeley neuroengineers to discuss the science behind ‘Transcendence’ April 7th, 2014

First annual science week highlights STEM pipeline and partnerships: UB, SUNY Buffalo State and ECC team up with the City of Buffalo and its schools for April 7-11 events April 3rd, 2014

Nanomedicine

Cloaked DNA nanodevices survive pilot mission: Successful foray opens door to virus-like DNA nanodevices that could diagnose diseased tissues and manufacture drugs to treat them April 22nd, 2014

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

Amino-functionalized carbon nanotubes act as a carrier for nerve growth factor April 21st, 2014

Newly-Produced Bone Cement Able to Carry Medicine April 21st, 2014

Announcements

Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells April 22nd, 2014

PETA science consortium to present hazard testing strategy at nanotoxicology meeting: High tech field ripe for use of sophisticated non-animal testing strategies April 22nd, 2014

Harris & Harris Group Notes the Receipt of Proceeds From the Sale of Molecular Imprints' Semiconductor Business to Canon April 22nd, 2014

National Space Society Congratulates SpaceX on the Success of CRS-3 and the First Flight of the Falcon 9R April 22nd, 2014

Nanobiotechnology

Cloaked DNA nanodevices survive pilot mission: Successful foray opens door to virus-like DNA nanodevices that could diagnose diseased tissues and manufacture drugs to treat them April 22nd, 2014

Targeting cancer with a triple threat: MIT chemists design nanoparticles that can deliver three cancer drugs at a time April 15th, 2014

Biologists Develop Nanosensors to Visualize Movements and Distribution of Plant Stress Hormone April 15th, 2014

In latest generation of tiny biosensors, size isn't everything: UCLA researchers overturn conventional wisdom on nanowire-based diagnostic devices April 11th, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE