Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Promising research breakthrough at Wake Forest University

Wake Forest physics professors Martin Guthold, left to right, Keith Bonin and Jed Macosko.
Wake Forest physics professors Martin Guthold, left to right, Keith Bonin and Jed Macosko.

Abstract:
Researchers cut years from drug development with nanoscopic bead technology

By Cheryl V. Walker

Promising research breakthrough at Wake Forest University

Winston-Salem, NC | Posted on July 26th, 2010

New research accepted by the Journal of Molecular Recognition confirms that a revolutionary technology developed at Wake Forest will slash years off the time it takes to develop drugs — bringing vital new treatments to patients much more quickly.

The new technology, "Lab-on-Bead," uses tiny beads studded with "pins" that match a drug to a disease marker in a single step, so researchers can test an infinite number of possibilities for treatments all at once. When Lab-on-Bead makes a match, it has found a viable treatment for a specific disease — speeding up drug discovery by as much as 10,000 times and cutting out years of testing and re-testing in the laboratory.

"It helps the most interesting new drugs work together to stick their heads up above the crowd," said Jed C. Macosko, an associate professor of physics and primary inventor of the Lab-on-Bead technology. "Each type of drug has its own molecular barcode. Then, with the help of matching DNA barcodes on each nanoscopic bead, all the drugs of a certain type find their own 'home' bead and work together to make themselves known in our drug discovery process. It's kind of like when Dr. Seuss's Whos down in Whoville all yelled together so that Horton the elephant and all of his friends could hear them."

Macosko and Martin Guthold, an associate professor of physics and the co-inventor of Lab-on-Bead, will work with the biotechnology startup NanoMedica Inc. to test how drug companies will use the new tool. The company has relocated to Winston-Salem from New Jersey; Macosko serves as the company's chief innovation officer and Guthold is its chief science officer. The company has one year to work with the technology to bring it to market or relinquish the rights to the patent.

Lab-on-Bead screens millions of chemicals simultaneously using plastic beads so small that 1,000 of them would fit across a human hair. Pharmaceutical companies could use the technology to identify treatments and diagnostics for conditions ranging from cancer to Alzheimer's.

One of the targets the research team has focused on is a breast cancer cell called HER2. "We want to find a molecule that detects that cancer cell," Guthold said. "In that circumstance, you could use Lab-on-Bead as a diagnostic tool."

The North Carolina Biotechnology Center, a private, nonprofit corporation funded by the N.C. General Assembly, provided $75,000 in funding for the project. Harvard University and Université de Strasbourg in Strasbourg, France, are providing the chemicals being screened in the Lab-on-Bead process.

"There are an infinite number of possibilities for combining carbon, nitrogen, hydrogen and other elements into different shapes that interact differently in the cells," Macosko said. "Those shapes could block cancer — they could block all kinds of things. If there's some cure to a disease or way to diagnose it, we're going to find it faster."

The Journal of Molecular Recognition is the peer-reviewed publication of the International Society of Molecular Recognition. The Lab-on-Bead study will be in the September/October issue; it appears online in advance of publication. Co-authors of the study include Natalie R. Gassman, J. Patrick Nelli, Samrat Dutta, Adam Kuhn and Keith Bonin, all of Wake Forest; and Zbigniew Pianowski and Nicolas Winssinger of Université de Strasbourg.

####

For more information, please click here

Contacts:
336-758-5000

Copyright © Wake Forest University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New star-shaped molecule breakthrough: Scientists at The University of Manchester have generated a new star-shaped molecule made up of interlocking rings, which is the most complex of its kind ever created September 22nd, 2014

Iranian Researchers Synthesize Stable Ceramic Nanopowders at Room Temperature September 20th, 2014

SouthWest NanoTechnologies (SWeNT) Receives NIST Small Business Innovation Research (SBIR) Phase 1 Award to Produce Greater than 99% Semiconducting Single-Wall Carbon Nanotubes September 19th, 2014

Toward optical chips: A promising light source for optoelectronic chips can be tuned to different frequencies September 19th, 2014

Govt.-Legislation/Regulation/Funding/Policy

New star-shaped molecule breakthrough: Scientists at The University of Manchester have generated a new star-shaped molecule made up of interlocking rings, which is the most complex of its kind ever created September 22nd, 2014

SouthWest NanoTechnologies (SWeNT) Receives NIST Small Business Innovation Research (SBIR) Phase 1 Award to Produce Greater than 99% Semiconducting Single-Wall Carbon Nanotubes September 19th, 2014

Big Results Require Big Ambitions: Three young UCSB faculty receive CAREER awards from the National Science Foundation September 18th, 2014

New non-invasive technique could revolutionize the imaging of metastatic cancer September 17th, 2014

Possible Futures

Air Force’s 30-year plan seeks 'strategic agility' August 1st, 2014

IBM Announces $3 Billion Research Initiative to Tackle Chip Grand Challenges for Cloud and Big Data Systems: Scientists and engineers to push limits of silicon technology to 7 nanometers and below and create post-silicon future July 10th, 2014

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014

Academic/Education

Biosensors Get a Boost from Graphene Partnership: $5 Million Investment Supports Dozens of Jobs and Development of 300mm Fabrication Process and Wafer Transfer Facility September 18th, 2014

Malvern technology delivers Malvern reliability in multi-disciplinary lab at Queen Mary University London September 9th, 2014

State University of New York Trustees Unanimously Approve SUNY Polytechnic Institute (SUNY Poly) as New Name for Merged SUNY CNSE / SUNYIT September 9th, 2014

New Vice President Takes Helm at CNSE CMOST: Catherine Gilbert To Lead CNSE Children’s Museum of Science and Technology Through Expansion And Relocation August 29th, 2014

Nanomedicine

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

The Pocket Project will develop a low-cost and accurate point-of-care test to diagnose Tuberculosis: ICN2 holds a follow-up meeting of the Project on September 18th - 19th September 18th, 2014

New non-invasive technique could revolutionize the imaging of metastatic cancer September 17th, 2014

Recruiting bacteria to be technology innovation partners: September 17th, 2014

Announcements

New star-shaped molecule breakthrough: Scientists at The University of Manchester have generated a new star-shaped molecule made up of interlocking rings, which is the most complex of its kind ever created September 22nd, 2014

Synthesis of Nanostructures with Controlled Shape, Size in Iran September 22nd, 2014

Iranian Scientists Separate Zinc Ion at Low Concentrations September 20th, 2014

Toward optical chips: A promising light source for optoelectronic chips can be tuned to different frequencies September 19th, 2014

Nanobiotechnology

New star-shaped molecule breakthrough: Scientists at The University of Manchester have generated a new star-shaped molecule made up of interlocking rings, which is the most complex of its kind ever created September 22nd, 2014

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

CiQUS researchers design an artificial nose to detect DNA differentiation with single nucleotide resolution September 18th, 2014

Biosensors Get a Boost from Graphene Partnership: $5 Million Investment Supports Dozens of Jobs and Development of 300mm Fabrication Process and Wafer Transfer Facility September 18th, 2014

Research partnerships

Biosensors Get a Boost from Graphene Partnership: $5 Million Investment Supports Dozens of Jobs and Development of 300mm Fabrication Process and Wafer Transfer Facility September 18th, 2014

The Pocket Project will develop a low-cost and accurate point-of-care test to diagnose Tuberculosis: ICN2 holds a follow-up meeting of the Project on September 18th - 19th September 18th, 2014

Recruiting bacteria to be technology innovation partners: September 17th, 2014

Carbon Sciences Developing Breakthrough Technology to Mass-Produce Graphene -- the New Miracle Material: Company Enters Into an Agreement With the University of California, Santa Barbara (UCSB) to Fund the Further Development of a New Graphene Process September 16th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE