Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Promising research breakthrough at Wake Forest University

Wake Forest physics professors Martin Guthold, left to right, Keith Bonin and Jed Macosko.
Wake Forest physics professors Martin Guthold, left to right, Keith Bonin and Jed Macosko.

Abstract:
Researchers cut years from drug development with nanoscopic bead technology

By Cheryl V. Walker

Promising research breakthrough at Wake Forest University

Winston-Salem, NC | Posted on July 26th, 2010

New research accepted by the Journal of Molecular Recognition confirms that a revolutionary technology developed at Wake Forest will slash years off the time it takes to develop drugs — bringing vital new treatments to patients much more quickly.

The new technology, "Lab-on-Bead," uses tiny beads studded with "pins" that match a drug to a disease marker in a single step, so researchers can test an infinite number of possibilities for treatments all at once. When Lab-on-Bead makes a match, it has found a viable treatment for a specific disease — speeding up drug discovery by as much as 10,000 times and cutting out years of testing and re-testing in the laboratory.

"It helps the most interesting new drugs work together to stick their heads up above the crowd," said Jed C. Macosko, an associate professor of physics and primary inventor of the Lab-on-Bead technology. "Each type of drug has its own molecular barcode. Then, with the help of matching DNA barcodes on each nanoscopic bead, all the drugs of a certain type find their own 'home' bead and work together to make themselves known in our drug discovery process. It's kind of like when Dr. Seuss's Whos down in Whoville all yelled together so that Horton the elephant and all of his friends could hear them."

Macosko and Martin Guthold, an associate professor of physics and the co-inventor of Lab-on-Bead, will work with the biotechnology startup NanoMedica Inc. to test how drug companies will use the new tool. The company has relocated to Winston-Salem from New Jersey; Macosko serves as the company's chief innovation officer and Guthold is its chief science officer. The company has one year to work with the technology to bring it to market or relinquish the rights to the patent.

Lab-on-Bead screens millions of chemicals simultaneously using plastic beads so small that 1,000 of them would fit across a human hair. Pharmaceutical companies could use the technology to identify treatments and diagnostics for conditions ranging from cancer to Alzheimer's.

One of the targets the research team has focused on is a breast cancer cell called HER2. "We want to find a molecule that detects that cancer cell," Guthold said. "In that circumstance, you could use Lab-on-Bead as a diagnostic tool."

The North Carolina Biotechnology Center, a private, nonprofit corporation funded by the N.C. General Assembly, provided $75,000 in funding for the project. Harvard University and Université de Strasbourg in Strasbourg, France, are providing the chemicals being screened in the Lab-on-Bead process.

"There are an infinite number of possibilities for combining carbon, nitrogen, hydrogen and other elements into different shapes that interact differently in the cells," Macosko said. "Those shapes could block cancer — they could block all kinds of things. If there's some cure to a disease or way to diagnose it, we're going to find it faster."

The Journal of Molecular Recognition is the peer-reviewed publication of the International Society of Molecular Recognition. The Lab-on-Bead study will be in the September/October issue; it appears online in advance of publication. Co-authors of the study include Natalie R. Gassman, J. Patrick Nelli, Samrat Dutta, Adam Kuhn and Keith Bonin, all of Wake Forest; and Zbigniew Pianowski and Nicolas Winssinger of Université de Strasbourg.

####

For more information, please click here

Contacts:
336-758-5000

Copyright © Wake Forest University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

A nanoscale wireless communication system via plasmonic antennas: Greater control affords 'in-plane' transmission of waves at or near visible light August 27th, 2016

Forces of nature: Interview with microscopy innovators Gerd Binnig and Christoph Gerber August 26th, 2016

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Graphene under pressure August 26th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Analog DNA circuit does math in a test tube: DNA computers could one day be programmed to diagnose and treat disease August 25th, 2016

New approach to determining how atoms are arranged in materials August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

Possible Futures

A nanoscale wireless communication system via plasmonic antennas: Greater control affords 'in-plane' transmission of waves at or near visible light August 27th, 2016

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Graphene under pressure August 26th, 2016

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

Academic/Education

AIM Photonics Announces Release of Process Design Kit (PDK) for Integrated Silicon Photonics Design August 25th, 2016

Nanotech Security Featured by Simon Fraser University: Company's Anti-Counterfeiting Technology Developed With the Help of University's 4D LABS Materials Research Institute August 21st, 2016

W.M. Keck Foundation awards Cal State LA a $375,000 research and education grant August 4th, 2016

Thomas Swan and NGI announce unique partnership July 28th, 2016

Nanomedicine

Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

50 years after the release of the film 'Fantastic Voyage,' science upstages fiction: Science upstages fiction with nanorobotic agents designed to travel in the human body to treat cancer August 25th, 2016

Tunneling nanotubes between neurons enable the spread of Parkinson's disease via lysosomes August 24th, 2016

Announcements

A nanoscale wireless communication system via plasmonic antennas: Greater control affords 'in-plane' transmission of waves at or near visible light August 27th, 2016

Forces of nature: Interview with microscopy innovators Gerd Binnig and Christoph Gerber August 26th, 2016

A promising route to the scalable production of highly crystalline graphene films August 26th, 2016

Graphene under pressure August 26th, 2016

Nanobiotechnology

Analog DNA circuit does math in a test tube: DNA computers could one day be programmed to diagnose and treat disease August 25th, 2016

Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

50 years after the release of the film 'Fantastic Voyage,' science upstages fiction: Science upstages fiction with nanorobotic agents designed to travel in the human body to treat cancer August 25th, 2016

Research partnerships

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

New theory could lead to new generation of energy friendly optoelectronics: Researchers at Queen's University Belfast and ETH Zurich, Switzerland, have created a new theoretical framework which could help physicists and device engineers design better optoelectronics August 23rd, 2016

A new way to display the 3-D structure of molecules: Metal-organic frameworks provide a new platform for solving the structure of hard-to-study samples August 21st, 2016

Researchers watch catalysts at work August 19th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic