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Home > Press > Reverse engineering tablets for counterfeit investigations

Abstract:
Chemical imaging specialists at Malvern Instruments are demonstrating how data derived from reverse engineering of pharmaceutical tablets can aid the fight against counterfeit drugs. Using the SyNIRgi near infrared chemical imaging (NIRCI) system they have been able to collect data detailed enough to characterize the formulation and processes used to create individual dosages. Results can be compared to both the original manufacturer specifications and a database of known counterfeits.

Reverse engineering tablets for counterfeit investigations

Malvern, UK | Posted on July 14th, 2010

An application note, entitled ‘NIR chemical imaging for tablet deconstruction: A case study for solid dosage forms' outlines the methodology required to produce this level of information. The free download is available from the Malvern Instrument website at: www.malvern.com/nircitablets

SyNIRgi combines the species identification capabilities of conventional near infrared spectroscopy with digital imaging, to answer the questions ‘what?', ‘how much?' and ‘where?'. Able to non-destructively analyze powders, granules and tablets of all shapes and sizes, SyNIRgi gives results in minutes. Not only does it have clear applications in counterfeit detection and as a tool for Quality by Design, it also takes the guesswork out of formulation development, speeds up QA/QC and aids rapid troubleshooting in manufacturing. No sample preparation is needed, data acquisition speeds are high, and by simply changing an objective the system can be quickly configured for either microscopic or macroscopic imaging.

To download the application note visit www.malvern.com/nircitablets

Malvern, Malvern Instruments and SyNIRgi are registered trademarks of Malvern Instruments Ltd

####

About Malvern Instruments
Malvern Instruments is a market leader in measuring performance controlling material properties. These include particle size, particle shape, zeta potential, molecular weight, size and conformation, rheological properties and chemical distribution. Malvern delivers the systems, support and expertise that ensure the analytical integrity and productivity needed to drive research, development and manufacturing.

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Contacts:
Trish Appleton
Kapler Communications
Knowledge Centre
Wyboston Lakes
Great North Road
Wyboston
Bedfordshire
MK44 3BY
UK
Tel: +44 (0)1480 479280
Fax: +44 (0)1480 470343

USA contact:

Marisa Fraser
Malvern Instruments Inc.
117 Flanders Road
Westborough
MA 01581-1042
USA
Tel: +1 508 768 6400
Fax: +1 508 768 6403


Please send sales enquiries to:

Alison Vines
Malvern Instruments Ltd
Enigma Business Park
Grovewood Road
Malvern
Worcestershire
WR14 1XZ
UK
Tel: +44 (0) 1684 892456
Fax: +44 (0) 1684 892789

Copyright © Malvern Instruments

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