Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > UCI researchers develop world’s first plastic antibodies

“Plastic antibodies” that UCI scientists used to stop the spread of bee venom in mice could be designed to combat deadlier toxins and pathogens.
Photo by Hoang Xuan Pham / University Communications
“Plastic antibodies” that UCI scientists used to stop the spread of bee venom in mice could be designed to combat deadlier toxins and pathogens. Photo by Hoang Xuan Pham / University Communications

Abstract:
In a breakthrough, UCI chemists create synthetic antibodies that block bee venom

UCI researchers develop world’s first plastic antibodies

Irvine, CA | Posted on June 23rd, 2010

UC Irvine researchers have developed the first "plastic antibodies" successfully employed in live organisms - stopping the spread of bee venom through the bloodstream of mice.

Tiny polymeric particles - just 1/50,000th the width of a human hair - were designed to match and encase melittin, a peptide in bee venom that causes cells to rupture, releasing their contents. Large quantities of melittin can lead to organ failure and death.

The polymer nanoparticles were prepared by "molecular imprinting" a technique similar to plaster casting: UCI chemistry professor Kenneth Shea and project scientist Yu Hoshino linked melittin with small molecules called monomers, solidifying the two into a network of long polymer chains. After the plastic hardened, they removed the melittin, leaving nanoparticles with minuscule melittin-shaped holes.

When injected into mice given high doses of melittin, these precisely imprinted nanoparticles enveloped the matching melittin molecules, "capturing" them before they could disperse and wreak havoc - greatly reducing deaths among the rodents.

"Never before have synthetic antibodies been shown to effectively function in the bloodstream of living animals," Shea says. "This technique could be utilized to make plastic nanoparticles designed to fight more lethal toxins and pathogens."

Takashi Kodama of Stanford University and Hiroyuki Koide, Takeo Urakami, Hiroaki Kanazawa and Naoto Oku of Japan's University of Shizuoka also contributed to the study, published recently in the Journal of the American Chemical Society.

Unlike natural antibodies produced by live organisms and harvested for medical use, synthetic antibodies can be created in laboratories at a lower cost and have a longer shelf life.

"The bloodstream includes a sea of competing molecules - such as proteins, peptides and cells - and presents considerable challenges for the design of nanoparticles," Shea says. "The success of this experiment demonstrates that these challenges can be overcome."

####

About University of California, Irvine
Founded in 1965, UCI is a top-ranked university dedicated to research, scholarship and community service. Led by Chancellor Michael Drake since 2005, UCI is among the most dynamic campuses in the University of California system, with nearly 28,000 undergraduate and graduate students, 1,100 faculty and 9,000 staff. Orange County’s largest employer, UCI contributes an annual economic impact of $3.9 billion. For more UCI news, visit www.today.uci.edu.

For more information, please click here

Contacts:
Media Contact
Laura Rico
University Communications
949-824-9055

Copyright © University of California, Irvine

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

CWRU researchers efficiently charge a lithium-ion battery with solar cell: Coupling with perovskite solar cell holds potential for cleaner cars and more August 27th, 2015

Successful boron-doping of graphene nanoribbon August 27th, 2015

Nanolab Technologies LEAPS Forward with High-Performance Analysis Services to the World: Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division August 27th, 2015

National Space Society Welcomes Janet Ivey As New NSS Governor: Janet Ivey of Janet's Planet is NOW IN ORBIT as a member of the Board of Governors of the National Space Society August 27th, 2015

Synthetic Biology

Scientists Create Synthetic Membranes That Grow Like Living Cells June 22nd, 2015

$8.5M Grant For Developing Nano Printing Technology: 4-D printing to advance chemistry, materials sciences and defense capabilities June 18th, 2015

How natural channel proteins move in artificial membranes June 3rd, 2015

Researchers of the University of Tartu create a centre for developing designer cells with new functions April 8th, 2015

Possible Futures

Sediment dwelling creatures at risk from nanoparticles in common household products August 13th, 2015

Harris & Harris Group Reports Financial Statements as of June 30, 2015, and Announces a Stock Repurchase Program August 10th, 2015

Molecular trick alters rules of attraction for non-magnetic metals August 5th, 2015

Global Carbon Nanotubes Industry 2015: Acute Market Reports August 4th, 2015

Academic/Education

Announcing Oxford Instruments and School of Physics signing a Memorandum of Understanding August 26th, 2015

Kwansei Gakuin University in Hyogo, Japan, uses Raman microscopy to study crystallographic defects in silicon carbide wafers August 25th, 2015

JPK reports on the use of a NanoWizard® AFM-SECM system at the Université Paris Diderot looking at nanoscale biostructures August 18th, 2015

Rice, Penn State open center for 2-D coatings: National Science Foundation selects universities to develop atom-thin materials with industry partners August 13th, 2015

Nanomedicine

These microscopic fish are 3-D-printed to do more than swim: Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities August 26th, 2015

Glitter from silver lights up Alzheimer's dark secrets August 25th, 2015

Cervical cancer detection goes portable August 25th, 2015

Antibacterial Nanocomposite Prevents Transmission of Infectious Diseases August 24th, 2015

Announcements

CWRU researchers efficiently charge a lithium-ion battery with solar cell: Coupling with perovskite solar cell holds potential for cleaner cars and more August 27th, 2015

Successful boron-doping of graphene nanoribbon August 27th, 2015

Nanolab Technologies LEAPS Forward with High-Performance Analysis Services to the World: Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division August 27th, 2015

National Space Society Welcomes Janet Ivey As New NSS Governor: Janet Ivey of Janet's Planet is NOW IN ORBIT as a member of the Board of Governors of the National Space Society August 27th, 2015

Nanobiotechnology

Nanotechnology that will impact the Security & Defense sectors to be discussed at NanoSD2015 conference August 25th, 2015

Louisiana Tech University researchers discover synthesis of a new nanomaterial: Interdisciplinary team creates biocomposite for first time using physiological conditions August 24th, 2015

How UEA research could help build computers from DNA August 19th, 2015

Biophysics: Formation of swarms in nanosystems August 18th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic