Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > New method manipulates particles for sensors, crime scene testing

This diagram depicts the design of a new "hybrid optoelectric" device. The device uses a tightly focused infrared laser beam to position tiny particles, such as viruses and bacteria, onto a sensor. (Han-Sheng Chuang/Purdue University Birck Nanotechnology Center)
This diagram depicts the design of a new "hybrid optoelectric" device. The device uses a tightly focused infrared laser beam to position tiny particles, such as viruses and bacteria, onto a sensor. (Han-Sheng Chuang/Purdue University Birck Nanotechnology Center)

Abstract:
Researchers at Purdue University have developed a potential new tool for medical diagnostics, testing food and water for contamination, and crime-scene forensics.

By Emil Venere

New method manipulates particles for sensors, crime scene testing

West Lafayette, IN | Posted on June 8th, 2010

The technique uses a combination of light and electric fields to position droplets and tiny particles, such as bacteria, viruses and DNA, which are contained inside the drops.

Other methods using either light or electric fields separately are able to position droplets or the particles they contain, but the new "hybrid optoelectric" device is able to do both, making it potentially practical for sensors and industrial processes, said mechanical engineering doctoral student Aloke Kumar.

Ordinarily, the particles inside droplets are detected when they randomly fall on a sensor's surface. However, the new method could improve sensor efficiency by actively moving particles to specific regions on an electronic chip for detection or analysis.

"This new hybrid technique is universal in the sense that we can manipulate a range of droplet and particle sizes, going all the way from microliter drops to particles a few nanometers long," said Steven T. Wereley, a professor of mechanical engineering who is working with Kumar.

The method offers promise for future "lab-on-a-chip" technology, using electronic chips to analyze biological samples for medical and environmental applications. Sensors based on the technique could make possible a new class of chemical analyses, or assays, with point-of-care devices in a doctor's office or hospitals.

Such sensors might be used to quickly analyze blood, urine and other bodily fluids for a range of applications, including drug screening; paternity testing; detecting coronary artery disease, tumors and various inherited diseases including cystic fibrosis; and detecting infectious diseases and bacteria, viruses and fungi that are difficult to culture using conventional laboratory methods.

"This technique also would be good for DNA tests, such as those used on the TV program 'CSI,' to identify crime suspects using only a small blood sample," Wereley said. "The idea is to use a chip to quickly carry out laboratory procedures called polymerase chain reaction and capillary electrophoresis. The new technology also should be good for testing food and water for pathogens such as E. coli or salmonella."

Critical to the technology are electrodes made of indium tin oxide, a transparent and electrically conductive material commonly used in consumer electronics for touch-screen displays. Liquid drops are positioned on the electrodes, and the infrared laser heats up both the electrodes and the droplets. Then electric fields in the electrodes cause the heated liquid to produce a "microfluidic vortex" of circulating liquid. This vortex enables researchers to position the particles in the circulating liquid by moving the infrared laser. The particles accumulate only where the laser is shined.

"Sensors are one of the immediate applications of this technology," said Kumar, who may continue the work as a postdoctoral researcher at the Oak Ridge National Laboratories, where he will complete a two-year Eugene Wigner Fellowship starting this month. "We should be able to improve the efficiency of sensors at least 10 times."

Findings were detailed in a research paper appearing June 1 in the journal Langmuir. The paper was written by Kumar, Wereley and former Purdue doctoral student Han-Sheng Chuang, now a postdoctoral researcher at the University of Pennsylvania. The research is based at the Birck Nanotechnology Center at Purdue's Discovery Park.

Purdue has filed a U.S. patent application on the design.

The technique might be used to manufacture sensors and other devices by modifying a phenomenon called the coffee-ring effect, which causes residue to form when liquid evaporates. Because the particles in the residue form only where the infrared laser shines, the procedure might be used to precisely position particles to create structures and circuits for biosensors and electronics.

"We have successfully used this technique to create spatially controlled microassemblies, and we hope that this would interest other research groups looking into the coffee-ring effect," Kumar said.

The work has been supported with funding from the National Science Foundation and the Micro/Nano Fluidics Fundamentals Focus (MF3) Center at the University of California, Irvine.


ABSTRACT

Dynamic Manipulation by Light and Electric Fields: Micrometer Particles to Microliter Droplets


Aloke Kumar,† Han-Sheng Chuang,†,‡ and Steven T. Wereley

†Birck Nanotechnology Center and School of Mechanical Engineering, Purdue University

‡Mechanical Engineering and Applied Mechanics, University of Pennsylvania


We demonstrate a new hybrid optoelectric technique that can manipulate objects across several length scales. The technique leverages a variety of different physical mechanisms to achieve the dynamic manipulation of droplets and also the in situ concentration of colloidal particles suspended in the droplets. Various physical mechanisms such as optoelectrowetting, electrothermal flows, and ac electroosmosis are leveraged through different modes of operation of the device. Each operational mode, which is activated through the proper combination of an applied ac bias and the illumination used, is characterized by the ability to manipulate objects on a certain length scale. We also demonstrate that the device lends itself to the active control of microstructure patterns that emerge from a droplet evaporation process.

####

For more information, please click here

Contacts:
Writer:
Emil Venere
(765) 494-4709


Sources:
Steven T. Wereley
765-494-5624


Aloke Kumar
765-586-7884

Copyright © Purdue University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Leti to Demo Wristband with Embedded Sensors to Diagnose Sleep Apnea: APNEAband, Which Will Be Demonstrated at CES 2018, Also Monitors Mountain Sickness, Dehydration, Dialysis Treatment Response and Epileptic Seizures December 12th, 2017

Leti Develops World’s First Micro-Coolers for CERN Particle Detectors: Leti Design, Fabrication and Packaging Expertise Extends to Very Large Scientific Instruments December 11th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Device makes power conversion more efficient: New design could dramatically cut energy waste in electric vehicles, data centers, and the power grid December 8th, 2017

Law enforcement/Anti-Counterfeiting/Security/Loss prevention

Counterfeits and product piracy can be prevented by security features, such as printed 3-D microstructures: Forgeries and product piracy are detrimental to society and industry -- 3-D microstructures can increase security -- KIT researchers develop innovative fluorescent 3-D stru November 15th, 2017

A dash of gold improves microlasers: The precious metal provides a 'nano' solution for improving disease detection, defense and cybersecurity applications October 9th, 2017

Graphene based terahertz absorbers: Printable graphene inks enable ultrafast lasers in the terahertz range September 13th, 2017

Leti and Partners in PiezoMAT Project Develop New Fingerprint Technology for Highly Reliable Security and ID Applications: Ultra-high Resolution Pressure Sensing Uses Matrices of Vertical Piezoelectric Nanowire To Reconstruct the Smallest Features of Human Fingerprints September 5th, 2017

Possible Futures

UCLA chemists synthesize narrow ribbons of graphene using only light and heat: Tiny structures could be next-generation solution for smaller electronic devices December 8th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Device makes power conversion more efficient: New design could dramatically cut energy waste in electric vehicles, data centers, and the power grid December 8th, 2017

Creating a new kind of metallic glass December 7th, 2017

Academic/Education

Luleĺ University of Technology is using the Deben CT5000TEC stage to perform x-ray microtomography experiments with the ZEISS Xradia 510 Versa to understand deformation and strain inside inhomogeneous materials November 7th, 2017

Park Systems Announces the Grand Opening of the Park NanoScience Center at SUNY Polytechnic Institute November 3rd, 2017

Two Scientists Receive Grants to Develop New Materials: Chad Mirkin and Monica Olvera de la Cruz recognized by Sherman Fairchild Foundation August 16th, 2017

Moving at the Speed of Light: University of Arizona selected for high-impact, industrial demonstration of new integrated photonic cryogenic datalink for focal plane arrays: Program is major milestone for AIM Photonics August 10th, 2017

Nanomedicine

Leti to Demo Wristband with Embedded Sensors to Diagnose Sleep Apnea: APNEAband, Which Will Be Demonstrated at CES 2018, Also Monitors Mountain Sickness, Dehydration, Dialysis Treatment Response and Epileptic Seizures December 12th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Arrowhead Presents New Clinical Data Demonstrating a Sustained Host Response in Hepatitis B Patients Following RNAi Therapy — Up to 5.0 log10 reduction in HBsAg observed; data presented at HEP DART 2017 — December 6th, 2017

Copper will replace toxic palladium and expensive platinum in the synthesis of medications: The effectiveness of copper nanoparticles as a catalyst has been proven December 5th, 2017

Sensors

Leti to Demo Wristband with Embedded Sensors to Diagnose Sleep Apnea: APNEAband, Which Will Be Demonstrated at CES 2018, Also Monitors Mountain Sickness, Dehydration, Dialysis Treatment Response and Epileptic Seizures December 12th, 2017

Leti Develops World’s First Micro-Coolers for CERN Particle Detectors: Leti Design, Fabrication and Packaging Expertise Extends to Very Large Scientific Instruments December 11th, 2017

Graphene oxide making any material suitable to create biosensors: Scientists from Tomsk Polytechnic University have developed a new tool for biomedical research focused on single-cell investigation November 27th, 2017

The stacked color sensor: True colors meet minimization November 16th, 2017

Announcements

Leti to Demo Wristband with Embedded Sensors to Diagnose Sleep Apnea: APNEAband, Which Will Be Demonstrated at CES 2018, Also Monitors Mountain Sickness, Dehydration, Dialysis Treatment Response and Epileptic Seizures December 12th, 2017

Leti Develops World’s First Micro-Coolers for CERN Particle Detectors: Leti Design, Fabrication and Packaging Expertise Extends to Very Large Scientific Instruments December 11th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Device makes power conversion more efficient: New design could dramatically cut energy waste in electric vehicles, data centers, and the power grid December 8th, 2017

Food/Agriculture/Supplements

Wheat gets boost from purified nanotubes: Rice University toxicity study shows plant growth enhanced by -- but only by -- purified nanotubes December 6th, 2017

Report highlights opportunities and risks associated with synthetic biology and bioengineering November 22nd, 2017

A new way to mix oil and water: Condensation-based method developed at MIT could create stable nanoscale emulsions November 8th, 2017

Quorum reports on how cryo prep techniques for SEM are being applied in the Laboratory of Food Technology & Engineering at the University of Ghent, Belgium November 7th, 2017

Nanobiotechnology

Arrowhead Presents New Clinical Data Demonstrating a Sustained Host Response in Hepatitis B Patients Following RNAi Therapy — Up to 5.0 log10 reduction in HBsAg observed; data presented at HEP DART 2017 — December 6th, 2017

Going swimmingly: Biotemplates breakthrough paves way for cheaper nanobots: By using bacterial flagella as a template for silica, researchers have demonstrated an easier way to make propulsion systems for nanoscale swimming robots November 30th, 2017

Drug-delivering nanoparticles seek and destroy elusive cancer stem cells November 28th, 2017

Graphene oxide making any material suitable to create biosensors: Scientists from Tomsk Polytechnic University have developed a new tool for biomedical research focused on single-cell investigation November 27th, 2017

Photonics/Optics/Lasers

Leti Integrates Hybrid III-V Silicon Lasers on 200mm Wafers with Standard CMOS Process December 6th, 2017

Scientists make transparent materials absorb light December 1st, 2017

Going swimmingly: Biotemplates breakthrough paves way for cheaper nanobots: By using bacterial flagella as a template for silica, researchers have demonstrated an easier way to make propulsion systems for nanoscale swimming robots November 30th, 2017

Fast flowing heat in graphene heterostructures: Surprisingly fast heat flow from graphene to its surrounding November 29th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project