Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Taiwan Scientists Advance Technology Used for Quantitative Measurement of Nano-/microparticle Uptake by Cells

Abstract:
A Taiwan research team has developed a new approach for investigating the amount of nano-/microparticles taken up by mammalian cells.

Taiwan Scientists Advance Technology Used for Quantitative Measurement of Nano-/microparticle Uptake by Cells

Taiwan | Posted on May 31st, 2010

This project was led by Dr. Chung-Hsuan Chen, Distinguished Research Fellow and Director of the Genomics Research Center (GRC) at Academia Sinica, and Dr. Wen-Ping Peng, a Jointly-appointed Assistant Professor of the GRC and the Department of Physics at National Dong Hwa University of Taiwan, in collaboration with Dr. Alice Yu, Distinguished Research Fellow and Deputy Director of the GRC. The research was published online in the leading international journal, Angewandte Chemie, on April 13, 2010.

Nano-/microparticles have been pursued by researchers in recent years as possible carriers for drug delivery. Therefore, effective quantitative measurement of the cellular uptake of nano-/microparticles is of great importance. Conventionally these tiny particles have been measured using certain types of mass spectrometry (an analytical technique for the determination of the elemental composition of a sample or molecule) including Inductively Coupled Plasma Atomic Emission Spectroscopy and Inductively Coupled Plasma Mass Spectrometry (ICP-MS). However, these methods of measurement are limited to elemental particles such as gold nanoparticles.

For this study, scientists used a different type of spectrometer called the Charge-Monitoring Mass Spectrometer (CMS), a device which was itself developed by a group at the GRC and the Institute of Atomic and Molecular Sciences at Academia Sinica in 2007 to measure single cancer cells at higher speeds. This time, researchers from the GRC Physical and Computational Genomics group used this recently-developed device to measure the masses of cells of nano-/microparticle, a novel approach for investigating the amount of nano-/microparticle uptake into mammalian cells.

The group's findings indicate that the CMS is an adequate tool for time-resolved measurements of nanogold uptake by cells. They also found that the CMS could measure particles over a larger size range from 30nm to 250 nm. In addition, as the CMS only takes two-steps to examine the nanogold and the ICP-MS takes five-steps, the CMS analysis is more time-efficient. Most importantly, however, the CMS will also be able to measure non-metal nano particles, including polymeric nanoparticles, carbon nanotubes, diamond nanoparticles, viruses, micelles and liposomes in addition to elemental particles.

"This research brings more efficiency to the measurement and detection of the mass changes of a cell as a result of malignancy or the uptake of nanoparticles. The CMS is proven to be useful in streamlining the determination the quantity of both gold and polystyrene nano-/microparticles taken up into cells. We expect that such device will be of importance in medical applications," noted the first author of the study, Huan-Chang Lin, a Ph.D. candidate in the Department of Bio-Industrial Mechatronics Engineering at National Taiwan University.

This research is co-funded by the National Science Council, Academia Sinica and the National Health Research Institute. The full list of authors is Huan-Chang Lin, Hsin-Hung Lin, Cai-Yu Kao, Alice L. Yu, Wen-Ping Peng and Chung-Hsuan Chen.

The full-text of the study was published under the title Quantitative Measurement of Nano-/Microparticle Endocytosis by Cell Mass Spectrometry, available at the Angewandte Chemie website at: www3.interscience.wiley.com/journal/123349954/abstract?CRETRY=1&SRETRY=0.

Angewandte Chemie is published by the German Chemical Society. In 2008 it had an impact factor of 10.879.

####

For more information, please click here

Contacts:
Media Contacts:
Dr. Chung-Hsuan Chen
Genomics Center, Academia Sinica
(Tel) +886-2-2787-1200

Dr. Wen-Ping Peng
Department of Physics
National Dong Hwa University
(Tel) +886-3-8633-733

Fang-Hsun Yeh
Public Relations Office, Central Office of Administration
Academia Sinica
(Tel) +886-2-2789-8824
(M) 0922-036-691


Mei-Hui Lin
Public Relations Office, Central Office of Administration
Academia Sinica
(Tel) +886-2-2789-8821
(M) 0921-845-234

Copyright © Academia Sinica

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Govt.-Legislation/Regulation/Funding/Policy

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Academic/Education

First Canada Excellence Research Chair gets $10 million from the federal government for oilsands research at the University of Calgary: Federal government announces prestigious research chair to study improving oil production efficiency October 19th, 2014

Raytheon, UMass Lowell open on-campus research institute: Industry leader’s researchers to collaborate with faculty, students to move key technologies forward through first-of-its-kind partnership October 11th, 2014

SUNY Colleges of Nanoscale Science and Engineering and National Institute for Occupational Safety and Health Announce Expanded Partnership October 2nd, 2014

Yale University and Leica Microsystems Partner to Establish Microscopy Center of Excellence: Yale Welcomes Scientists to Participate in Core Facility Opening and Super- Resolution Workshops October 20 Through 31, 2014 September 30th, 2014

Nanomedicine

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

Journal Nanotechnology Progress International (JONPI), 2014, Volume 5, Issue 1, pp 1-24 October 22nd, 2014

TARA Biosystems and Harris & Harris Group Form Company to Improve Safety and Efficacy of New Therapies October 22nd, 2014

Announcements

NanoTechnology for Defense (NT4D) October 22nd, 2014

Mechanism behind nature's sparkles revealed October 22nd, 2014

TARA Biosystems and Harris & Harris Group Form Company to Improve Safety and Efficacy of New Therapies October 22nd, 2014

Researchers patent a nanofluid that improves heat conductivity October 22nd, 2014

Tools

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

Nanobiotechnology

Mechanism behind nature's sparkles revealed October 22nd, 2014

‘Designer’ nanodevice could improve treatment options for cancer sufferers October 22nd, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

Scientists Map Key Moment in Assembly of DNA-Splitting Molecular Machine: Crucial steps and surprising structures revealed in the genesis of the enzyme that divides the DNA double helix during cell replication October 15th, 2014

Research partnerships

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

Nitrogen Doped Graphene Characterized by Iranian, Russian, German Scientists October 21st, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE