Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanoparticles Unlock Tumor Identity

Abstract:
Using nanoparticles designed to recognize specific sugar-binding molecules on the surfaces of cells, a team of investigators at Michigan State University has developed a process that uses magnetic resonance imaging (MRI) to unlock the sugar-based code that identifies different types of cancer and normal cells. This work, led by Xuefei Huang, Ph.D., was published in the Journal of the American Chemical Society.

Nanoparticles Unlock Tumor Identity

Bethesda, MD | Posted on March 22nd, 2010

The investigators began their study by synthesizing a collection of magnetic nanoparticles, each coated with a different type of sugar. All mammalian cells contain a collection of sugar-binding receptors, known as lectins, on their surfaces, and each lectin has a characteristic affinity for one or more sugars. By using multiple nanoparticles, each coated with a different sugar, Dr. Huang's team was able to identify a sugar-binding signature that was characteristic of specific types of cells. Because the nanoparticles are strongly magnetic, they are readily imaged using magnetic resonance imaging (MRI), with each nanoparticle generating a well-differentiated MRI signal.

With five different sugar-coated magnetic nanoparticles in hand, the researchers tested their ability to discriminate among 10 different types of cells. Using a mathematical method known as linear discriminant analysis, the investigators showed that they could readily identify all 10 cell types through an analysis of the combined MRI signals produced by each nanoparticle. Not only was this method able to distinguish between malignant and normal cells, but between closely related cancer cells that are indistinguishable based on a qualitative analysis of their sugar or protein composition.

This work is detailed in a paper titled, "Magnetic Glyco-Nanoparticles: A Tool to Detect, Differentiate, and Unlock the Glyco-Codes of Cancer via Magnetic Resonance Imaging." An abstract of this paper is available at the journal's Web site.

View abstract: pubs.acs.org/doi/abs/10.1021/ja100455c

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

International research partnership tricks the light fantastic March 2nd, 2015

UC research partnership explores how to best harness solar power March 2nd, 2015

Researchers turn unzipped nanotubes into possible alternative for platinum: Aerogel catalyst shows promise for fuel cells March 2nd, 2015

Important step towards quantum computing: Metals at atomic scale March 2nd, 2015

Possible Futures

European roadmap for graphene science and technology published February 25th, 2015

Quantum research past, present and future for discussion at AAAS February 16th, 2015

World’s first compact rotary 3D printer-cum-scanner unveiled at AAAS by NTU Singapore start-up: With production funded by crowdsourcing, the first unit will be delivered to the United States in March February 16th, 2015

Nanotechnology Electric Vehicle (EV) Market Analysis Report 2015: According to Radiant Insights, Inc February 13th, 2015

Academic/Education

NanoTecNexus Launches New App for Learning About Nanotechnology—STEM Education Project Spearheaded by Interns February 26th, 2015

SUNY Poly CNSE Researchers and Corporate Partners to Present Forty Papers at Globally Recognized Lithography Conference: SUNY Poly CNSE Research Group Awarded Both ‘Best Research Paper’ and ‘Best Research Poster’ at SPIE Advanced Lithography 2015 forum February 25th, 2015

KIT Increases Commitment in Asia: DAAD Funds Two New Projects: Strategic Partnerships with Chinese Universities and Communi-cation Technologies Network February 22nd, 2015

Minus K Technology Announces Its 2015 Vibration Isolator Educational Giveaway to U.S. Colleges and Universities February 18th, 2015

Nanomedicine

New nanodevice defeats drug resistance: Tiny particles embedded in gel can turn off drug-resistance genes, then release cancer drugs March 2nd, 2015

New Hopes for Treatment of Intestine Cancer by Edible Nanodrug March 2nd, 2015

Graphene Shows Promise In Eradication Of Stem Cancer Cells March 1st, 2015

Novel Method to Determine Optical Purity of Drug Components March 1st, 2015

Announcements

International research partnership tricks the light fantastic March 2nd, 2015

UC research partnership explores how to best harness solar power March 2nd, 2015

Researchers turn unzipped nanotubes into possible alternative for platinum: Aerogel catalyst shows promise for fuel cells March 2nd, 2015

Important step towards quantum computing: Metals at atomic scale March 2nd, 2015

Nanobiotechnology

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Bacteria network for food: Bacteria connect to each other and exchange nutrients February 23rd, 2015

Building tailor-made DNA nanotubes step by step: New, block-by-block assembly method could pave way for applications in opto-electronics, drug delivery February 23rd, 2015

Better batteries inspired by lowly snail shells: Biological molecules can latch onto nanoscale components and lock them into position to make high performing Li-ion battery electrodes, according to new research presented at the 59th annual meeting of the Biophysical Society February 12th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE