Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Gold Nanobeacons Detect Sentinel Lymph Nodes

Abstract:
Virtually every patient diagnosed with breast cancer or melanoma undergoes lymph node biopsy to determine if their cancer has begun spreading in the body. Taking this biopsy involves an invasive and uncomfortable procedure, and though necessary it detects metastases less than 95% of the time. To eliminate the need for invasive biopsy, and to improve upon the diagnostic sensitivity of biopsy, researchers have been working to develop non-invasive imaging techniques to identify tumor-bearing sentinel lymph nodes.

Gold Nanobeacons Detect Sentinel Lymph Nodes

Bethesda, MD | Posted on March 22nd, 2010

Now, a group of investigators at Washington University of St. Louis, led by Dipanjan Pan, Ph.D., and including Gregory Lanza, M.D., and Samuel Wickline, M.D., both members of the Siteman Center of Cancer Nanotechnology Excellence, has developed "soft" gold nanoparticles that accumulate in sentinel lymph nodes and that are visible using a technique known as photoacoustic imaging. The investigators published their results in the journal Biomaterials.

Photoacoustic imaging combines aspects of optical and ultrasound imaging in a sensitive imaging technique suitable for use in the human body. Photoacoustic imaging agents, including gold nanoparticles, emit sound waves when illuminated with specific frequencies of light. In the case of gold nanoparticles, the activating light energy occurs in the near infrared, a region of the optical spectrum that passes readily through biological tissues, and their photoacoustic emissions are strong enough to be detectable using standard clinical ultrasound equipment.

The key to this study was developing a gold nanoparticle imaging agent that balances the rate of accumulation in sentinel lymph nodes with the rate of elimination of particles that the lymph nodes do not trap. The solution was to wrap multiple gold nanoparticles, each 2-4 nanometers in diameter, within a soft polymer matrix, producing a 90 nanometer gold nanobeacon that accumulates rapidly in sentinel lymph nodes. When the investigators injected their nanobeacons into mice and imaged lymph nodes one hour later, they found that the photoacoustic signal was nine-fold stronger in lymph nodes than in surrounding blood vessels. While larger nanoparticles produced a stronger signal, they did not accumulate exclusively in the lymph nodes, so the contrast they produced was much smaller.

This work, which is detailed in a paper titled, "Near infrared photoacoustic detection of sentinel lymph nodes with gold nanobeacons," was supported in part by the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative designed to accelerate the application of nanotechnology to the prevention, diagnosis, and treatment of cancer. An abstract of this paper is available at the journal's Web site.

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Carbon Sciences Developing Breakthrough Technology to Mass-Produce Graphene -- the New Miracle Material: Company Enters Into an Agreement With the University of California, Santa Barbara (UCSB) to Fund the Further Development of a New Graphene Process September 16th, 2014

Nanoribbon film keeps glass ice-free: Rice University lab refines deicing film that allows radio frequencies to pass September 16th, 2014

Effective Nanotechnology Innovations to Receive Mustafa Prize September 16th, 2014

‘Small’ transformation yields big changes September 16th, 2014

Possible Futures

Air Force’s 30-year plan seeks 'strategic agility' August 1st, 2014

IBM Announces $3 Billion Research Initiative to Tackle Chip Grand Challenges for Cloud and Big Data Systems: Scientists and engineers to push limits of silicon technology to 7 nanometers and below and create post-silicon future July 10th, 2014

Virus structure inspires novel understanding of onion-like carbon nanoparticles April 10th, 2014

Local girl does good March 22nd, 2014

Academic/Education

Malvern technology delivers Malvern reliability in multi-disciplinary lab at Queen Mary University London September 9th, 2014

State University of New York Trustees Unanimously Approve SUNY Polytechnic Institute (SUNY Poly) as New Name for Merged SUNY CNSE / SUNYIT September 9th, 2014

New Vice President Takes Helm at CNSE CMOST: Catherine Gilbert To Lead CNSE Children’s Museum of Science and Technology Through Expansion And Relocation August 29th, 2014

RMIT delivers $30m boost to micro and nano-tech August 26th, 2014

Nanomedicine

Treatment of Cell Infection by Nanotechnology September 15th, 2014

Researchers Create World’s Largest DNA Origami September 11th, 2014

Iranian Scientists Discover Nanotechnology Method to Remove Limitations in Tumor Surgery September 11th, 2014

Iranian Nanotechnology Scientists Produce Polymeric Scaffolds for Tissue Engineering September 11th, 2014

Announcements

Carbon Sciences Developing Breakthrough Technology to Mass-Produce Graphene -- the New Miracle Material: Company Enters Into an Agreement With the University of California, Santa Barbara (UCSB) to Fund the Further Development of a New Graphene Process September 16th, 2014

Nanoribbon film keeps glass ice-free: Rice University lab refines deicing film that allows radio frequencies to pass September 16th, 2014

Effective Nanotechnology Innovations to Receive Mustafa Prize September 16th, 2014

‘Small’ transformation yields big changes September 16th, 2014

Nanobiotechnology

NanoStruck has a High Recovery Rate on Mine Tailings: retrieval of up to 96% of Gold, 88% of Silver and 86% of Palladium September 12th, 2014

Boosting armor for nuclear-waste eating microbes September 12th, 2014

Researchers Create World’s Largest DNA Origami September 11th, 2014

UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique: Oil-and-water approach from Richmond's UO lab to spark new line of versatile peptoid nanosheets September 2nd, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE