Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Defining the Design Rules for Targeted Nanoparticles Used To Image Tumors

Abstract:
One of the challenges of using nanoparticles for imaging tumors during surgery is that there needs to be a tradeoff between the number of nanoparticles that target a tumor and the rapid clearance of any unbound nanoparticles from the body. A large number of nanoparticles sticking tightly to a tumor will provide a bright signal that can help a surgeon spot the edges of the malignant tissue, but only if the background signal from unbound nanoparticles - the ones circulating freely through the body - is not too high.

Defining the Design Rules for Targeted Nanoparticles Used To Image Tumors

Bethesda, MD | Posted on February 19th, 2010

Now, a team of investigators has developed a set of design rules that can optimize that tradeoff, producing nanoparticles that have the best chance of binding to a tumor but that will clear rapidly through the kidneys when they do not find their target. The team, led by John Frangioni, from the Beth Israel Deaconess Medical Center, and Moungi Bawendi, of the Massachusetts Institute of Technology and a member of the MIT-Harvard Center of Cancer Nanotechnology Excellence, published the results of their work in the journal Nature Nanotechnology.

In earlier work, the investigators had found that the kidneys efficiently filter out of the blood stream nanoparticles of approximately 5.5 nanometers (nm) in diameter and that are zwitterionic, that is they have both positive and negative charges on their surface. The researchers also developed ultrasmall, zwitterionic, brightly fluorescent nanoparticles consisting of a zinc-cadmium sulfide core surrounded by a cadmium selenide shell and a cysteine coating.

In this study, the investigators linked one of two tumor targeting agents to the cysteine coating and tested the ability of the two formulations to target tumors and yet be cleared from circulation. While the usual approach to developing targeted nanoparticles has been to add as large a number of targeting molecules as possible in order to increase the probability of sticking to the targeted tissue, the investigators found that they could only add between five and ten targeting molecules without increasing the overall size of the nanoparticle above the 5.5 nm cutoff. Of equal importance, they also found that nanoparticles prepared in this manner did not bind to blood stream proteins, which would have had the effect of increasing the overall size of the nanoparticles.

Tests in animals using cultured cells showed that using even relatively low numbers of targeting molecules produced nanoparticles capable of binding tightly to targeted tumor cells. Biodistribution studies showed that the nanoparticles accumulated in targeted tumors, where they could be imaged, but not in the liver, spleen, and lungs, tissues that often accumulate circulating nanoparticles. Unbound nanoparticles were excreted through the kidneys, as predicted, within 4 hours. Four-hour clearance is important because it means that in practice, a patient scheduled for tumor-removing surgery could receive a dose of the nanoparticles when first arriving at the hospital and that background levels of unbound nanoparticles would be close to zero by the time the surgeon needed to image labeled tumors.

This work, which is detailed in a paper titled "Design considerations for tumour-targeted nanoparticles," was supported in part by the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative designed to accelerate the application of nanotechnology to the prevention, diagnosis, and treatment of cancer. An abstract of this paper is available at the journal's website.

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Atom-thick CCD could capture images: Rice University scientists develop two-dimensional, light-sensitive material December 20th, 2014

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Aculon Hires New Business Development Director December 19th, 2014

Possible Futures

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Researchers discern the shapes of high-order Brownian motions November 17th, 2014

VDMA Electronics Production Equipment: Growth track for 2014 and 2015 confirmed: Business climate survey shows robust industry sector November 14th, 2014

Open Materials Development Will Be Key for HP's Success in 3D Printing: HP can make a big splash in 3D printing, but it needs to shore up technology claims and avoid the temptation of the razor/razor blade business model in order to flourish November 11th, 2014

Academic/Education

SUNY Poly NanoCollege Faculty Member Selected as American Physical Society Fellow: SUNY Poly Associate Professor of Nanoscience Dr. Vincent LaBella Recognized for Significant Technological Innovations that Enable Interactive Learning December 17th, 2014

Nanomedicine expert joins Rice faculty: Gang Bao combines genetic, nano and imaging techniques to fight disease December 17th, 2014

FEI and Oregon Health & Science University Install a Complete Correlative Microscopy Workflow in Newly Built Collaborative Science Facility December 16th, 2014

Student Nanotechnology Laboratories Network Set Up in Iran December 15th, 2014

Nanomedicine

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Unraveling the light of fireflies December 17th, 2014

First Home-Made Edible Herbal Nanodrug Presented to Pharmacies across Iran December 17th, 2014

Announcements

Atom-thick CCD could capture images: Rice University scientists develop two-dimensional, light-sensitive material December 20th, 2014

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Aculon Hires New Business Development Director December 19th, 2014

Nanobiotechnology

Scientists trace nanoparticles from plants to caterpillars: Rice University study examines how nanoparticles behave in food chain December 16th, 2014

FEI and Oregon Health & Science University Install a Complete Correlative Microscopy Workflow in Newly Built Collaborative Science Facility December 16th, 2014

UCLA engineers first to detect and measure individual DNA molecules using smartphone microscope December 15th, 2014

Biomimetic dew harvesters: Understanding how a desert beetle harvests water from dew could improve drinking water collection in dew condensers December 8th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE